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Protein Overview: RIX1

General Information:
Name(s) found: RIX1 / YHR197W [SGD]
Description(s) found:
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  • gi|731766|sp|P38883.1|RIX1_YEAST RecName: Full=Pre-rRNA-processing protein RIX1; AltName: Full=Ribosomal export protein 1; AltName: Full=Involved in processing IST2 protein 2 [NCBI NR]
  • gi|6321991|ref|NP_012067.1| Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles; Rix1p [Saccharomyces cerevisi [NCBI NR]
  • pir||S46678 hypothetical protein YHR197w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|458930|gb|AAB68356.1| Yhr197wp [Saccharomyces cerevisiae] [NCBI NR]
  • Uncharacterized protein YHR197W - Saccharomyces cerevisiae (Baker's yeast) [Swiss-Prot]
  • Pre-rRNA-processing protein RIX1 OS=Saccharomyces cerevisiae GN=RIX1 PE=1 SV=1 [Swiss-Prot]
  • RIX1 RIbosome eXport protein [mips]
  • Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles [SGD]
  • YHR197W, Chr VIII from 493892-496183 [yeast_orfs2]
  • Chr VIII from 493892-496183 [yeastorf3.fasta]
  • (P38883) Hypothetical 86.7 kDa protein in EGD2-SUN1 intergenic region [4932.FASTACCERV.txt]
  • RIX1 SGDID:S0001240, Chr VIII from 493894-496185, Verified ORF [yeastflysequest.fasta]
  • RIX1 SGDID:S0001240, Chr VIII from 493895-496186, Verified ORF [10112005cervSGD.fasta]
  • RIbosome eXport; Protein required for cell viability [Saccharomyces cerevisiae]gi|731766|sp|P38883|YHZ7_YEAST Hypothetical 86.7 kDa protein in EGD2-SUN1 intergenic regiongi|458930|gb|AAB68356.1| Yhr197wp [Saccharomyces cerevisiae]gi|626699|pir||S46678 [nrdb_11152004_Chlamydomonas]
  • RIX1 SGDID:S000001240, Chr VIII from 493896-496187, Verified ORF, "Essential protein involved in the processing of the ITS2 region of the rRNA locus; required for the maturation and nuclear export of the 60S ribosomal subunit" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • RIX1 SGDID:S000001240, Chr VIII from 493896-496187, Verified ORF, "Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal p [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Uncharacterized protein YHR197W [nr-271106-contam.fasta]
  • Essential protein involved in the processing of the ITS2 region of the rRNA locus; required for the maturation and nuclear export of the 60S ribosomal subunit; Rix1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Yhr197wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • RIX1 SGDID:S000001240, Chr VIII from 493896-496187, Verified ORF, "Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 763 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nuclear outer membrane [IMPLink to PubMed article]
    nucleoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: ribosomal subunit export from nucleus [IMPLink to PubMed article][IPILink to PubMed article][TASLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    ribosomal large subunit assembly [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEEFIAVST LARNLEIAKG NEFHTILATL RSPVYINEQL LKSELSFLVT KILKLIRSGN  60
   61 DFDLWKGCHT SVVTCAYNPL VLSTHGGQLL AAIYSRLEQK TGFYSSVISS SHGKQLFNTL 120
  121 ISSVAIIIDL MKNKPTLSRE ALVPKLKAII PTLITLSQYE PELVLPVLQR ILKRNTTTFK 180
  181 PFTNKFRTVL INLIISDYAS LGTKTQRLVC ENFAYLHLLK IQVSDTSDDE TQAHHKIYAD 240
  241 SNWRTGLMSI LSQFKPIIQL CGEILDFEQD NELYKLIKSL PVIDESNNKE EFLPSLKLDF 300
  301 NAPLTLWEIP QRLSLLADML VAFISLPTPF PIRVPLGGIN SLCEVLLGVS NKYLPLKKEL 360
  361 RHDNELNGVI NTILPQIQFQ GIRLWEIMVS KYGKCGLSFF EGILSSIELF IPLKKKSNNE 420
  421 IDFNVVGSLK FEFATVFRLV NMILSHLGHQ LNIISVISQL IEVALFLSHD KTLIDSLFKN 480
  481 RKSIMKQQTK TKQSKRSKSA EGAFSDIYTH PELFVCKNSM NWFNEINDFF ITALNNWILP 540
  541 STPHIQILKY SITQSLRLKE RFGYIPESFV NLLRCEVLHP GSERVSILPI AISLLKNIND 600
  601 DMFELLCHPK VPVGMVYQLH KPLDLGEDGE VRDDINKKEV ETNESSSNAN TGLETLKALE 660
  661 NLENVTIPEP KHEVPKVVDD TAIFKKRSVE EVIERESTSS HKKVKFVEET TVDNGEELIV 720
  721 KKAVSQTKEE EKPMEDSEDE EQEEFEIPAI ELSDDEEEEE EGE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARX1 BRX1 BUD20 CIC1 DBP10 DRS1 ERB1 HAS1 IPI1 IPI3 MDN1 MRT4 NIP7 NOC2 NOC3 NOG1 NOG2 NOP15 NOP2 NOP7 NSA1 NSA2 NUG1 PUF6 RIX1 RIX7 RLP7 RPF1 RPL25 RSA4 SDA1 SPB1 SPB4 TIF6 YTM1
    View Details Hazbun TR, et al. (2003) IPI1 IPI3 RIX1
    View Details Krogan NJ, et al. (2006) IPI1 IPI3 RIX1
    View Details Gavin AC, et al. (2006) BUD20 IPI3 NOG1 NOG2 NSA2 NUG1 RIX1 RPF2 RSA4 SDA1
    View Details Gavin AC, et al. (2002) ARX1 BEM2 BMS1 BRX1 BUD20 CCM1 CIC1 CLU1 CYR1 CYS4 DBP10 DBP9 DCP2 DRS1 EBP2 ECM16 EHD3 ERB1 FPR4 FYV4 GCN1 GEP3 HAS1 HDA1 HER1 HIS3 HSC82 INP2 IPI1 IPI3 KRE33 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MRP1 MRP10 MRP13 MRP17 MRP21 MRP4 MRP51 MRPS16 MRPS17 MRPS18 MRPS28 MRPS5 MRPS8 MRPS9 MRT4 NAM9 NAP1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 PAP2 PET123 PRT1 PSD2 PUF6 PUS7 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RSM10 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM7 RTR1 SDA1 SEC7 SKI2 SNU13 SPB1 SPB4 SSF1 TIF4631 TIF6 TUB3 UBP10 URB1 UTP10 UTP20 UTP22 YGL036W YTM1
    View Details Ho Y, et al. (2002) AFG2 ALB1 ARX1 ATP3 BUD20 BUD3 EHD3 FYV4 HHF1, HHF2 HTA1 HTB1 HTB2 IPI3 LHP1 MAM33 MNP1 MRPS16 NMD3 NOG1 NOP12 NOP13 NOP7 NSA2 NUG1 PRP43 PUF6 PWP1 RIX1 RPC19 RSM24 RSM25 YBL044W YDR131C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RIX1 No Comments Hazbun TR, et al. (2003)
    View Run RIX1 No Comments Hazbun TR, et al. (2003)
    View Run IPI1 No Comments Hazbun TR, et al. (2003)
    View Run IPI3 No Comments Hazbun TR, et al. (2003)
    View Run RIX1 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RIX1 IPI3 2 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RIX1 Unpublished Data
    View Data RIX1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..763] deduced N/A No confident structure predictions are available.
    2 View Details [113..227] deduced N/A No confident structure predictions are available.
    3 View Details [228..449] deduced N/A No confident structure predictions are available.
    4 View Details [450..628] deduced N/A No confident structure predictions are available.
    5 View Details [629..763] FFAS03 0.965 TUBULIN-PODOPHYLLOTOXIN: STATHMIN-LIKE DOMAIN COMPLEX

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  2.442176581181 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.76092523805452 bayes_pls_golite062009
  • tubulin binding
    		•  1.69041482180803 bayes_pls_golite062009
  • protein binding
    		•  1.57463316291212 bayes_pls_golite062009
  • microtubule binding
    		•  0.761981518588091 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle