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Protein Overview: PTC4

General Information:
Name(s) found: PTC4 / YBR125C [SGD]
Description(s) found:
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  • gi|6319601|ref|NP_009683.1| Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase a [NCBI NR]
  • gi|586537|sp|P38089.1|PP2C4_YEAST RecName: Full=Protein phosphatase 2C homolog 4; Short=PP2C-4 [NCBI NR]
  • gi|536409|emb|CAA85082.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|476078|emb|CAA55626.1| hyp. protein YBL0513 [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S48288 probable phosphoprotein phosphatase (EC 3.1.3.16) YBR0921 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Protein phosphatase 2C homolog 4 OS=Saccharomyces cerevisiae GN=PTC4 PE=1 SV=1 [Swiss-Prot]
  • (P38089) Protein phosphatase 2C homolog 4 (EC 3.1.3.16) (PP2C-4) [Swiss-Prot]
  • PTC4 Serine/threonine protein phosphatases (PP2Cs) [mips]
  • Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity [SGD]
  • PTC4, Chr II from 487157-488338, reverse complement [yeast_orfs2]
  • Chr II from 487157-488338, reverse complement [yeastorf3.fasta]
  • Chr II from 487156-488337, reverse complement [yeastorf4.fasta]
  • Chr II from 488335-487154, reverse complement [yeastorf5.fasta]
  • PTC4 SGDID:S0000329, Chr II from 488336-487155, reverse complement, Verified ORF [yeastflysequest.fasta]
  • PTC4 SGDID:S0000329, Chr II from 488374-487193, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Phosphatase type Two C; Type 2C protein phosphatase [Saccharomyces cerevisiae]gi|476078|emb|CAA55626.1| hyp. protein YBL0513 [Saccharomyces cerevisiae]gi|536409|emb|CAA85082.1| unnamed protein product [Saccharomyces cerevisiae]gi|586537|sp|P38089|P2C4_ [nrdb_11152004_Chlamydomonas]
  • PTC4 SGDID:S000000329, Chr II from 488374-487193, reverse complement, Verified ORF, "Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases h [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity; Ptc4p [Saccharomyce [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • hyp. protein YBL0513 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein phosphatase 2C homolog 4 (PP2C-4) [nr-271106-contam.fasta]
  • PTC4 SGDID:S000000329, Chr II from 488374-487193, reverse complement, Verified ORF, "Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Protein phosphatase 2C homolog 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PTC4 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PTC4 SGDID:S000000329, Chr II from 488380-487199, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity" [yeast-030211-contam.fasta]
  • PTC4 SGDID:S000000329, Chr II from 488380-487199, Genome Release 64-2-1, reverse complement, Verified ORF, "Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity" [20141208_orf_trans.fasta]
  • TR4381|c0_g1_i1|g.2922 ORF TR4381|c0_g1_i1|g.2922 TR4381|c0_g1_i1|m.2922 type:complete len:394 (+) TR4381|c0_g1_i1:196-1377(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta]
  • YBR125C SGDID:S000000329, Chr II from 488380-487199, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • ID=asmbl_4731|g.3047 ORF ID=asmbl_4731|g.3047 ID=asmbl_4731|m.3047 type:complete len:394 (+) ID=asmbl_4731:197-1378(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 393 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: protein serine/threonine phosphatase activity [IDA][IEA][ISS]
    phosphoprotein phosphatase activity [IEA]
    metal ion binding [IEA]
    catalytic activity [IEA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQLLSHPLT EKTIEYNEYK NNQASTGIVP RFYNCVGSMQ GYRLTQEDAH LIRNENSVVY  60
   61 VRFFNPFIDK YETLSLNVFA VFDGHGGDDC SKFLSGGRHH RDGNGSSNGN GEPNAGLIKW 120
  121 IAYSFENHHY TSTTNNDSSK FKRSFNTLEG LVSQIFKDAF ILQDEELYRH FANSSCGSTA 180
  181 VVACIINEES LYVANCGDSR CILSSKSNGI KTMSFDHKPQ HIGELIRIND NGGTVSLGRV 240
  241 GGVLALSRAF SDFQFKRGVT YPHRRTKLTN ITQNLTYGTP PQEAQVTVEP DVLMHKIDYS 300
  301 KDEFLVLACD GIWDIYNNKQ LIHFIKYHLV SGTKLDTIIT KLLDHGIAQA NSNTGVGFDN 360
  361 MTAIIVVLNR KGETLQDWFN KMKTRLERER GLV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) HAT1 HAT2 HIF1 PAA1 PTC4
    View Details Krogan NJ, et al. (2006) PAA1 PTC2 PTC3 PTC4 VPS34
    View Details Gavin AC, et al. (2006) PTC4 YDR186C
    View Details Gavin AC, et al. (2002) PAA1 PTC4 YDR186C
    View Details Ho Y, et al. (2002) ABP1 ACO1 AIM41 ATP4 BUD14 CAR2 COR1 CRZ1 CYS4 DCP1 DCP2 DNM1 EDC3 EDE1 EGD2 ENP1 GAS1 GCN3 GIN4 GPH1 HHF1, HHF2 HRR25 HSP104 HXT7 HYP2 IPP1 LOC1 LSP1 LTV1 MDH1 MDS3 MER1 MGE1 NSA1 NUG1 NUM1 OYE2 PAA1 PEX19 PIL1 PIN4 PTC4 PUF3 RIO2 RPC19 RPM2 SAP185 SAP190 SAS10 SEC2 SEC23 SEF1 SES1 SFB3 SGM1 SIT4 SKT5 SPT16 SYF1 TMA19 TPS1 TSR1 VHS1 VMA4 YBR225W YER138C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PTC4 YIL082W 2 Unpublished Fields Lab Data
    View Screen PTC4 PAA1 2 Unpublished Fields Lab Data
    View Screen PTC4 YFL063W 1 Unpublished Fields Lab Data
    View Screen PTC4 SML1 1 Unpublished Fields Lab Data
    View Screen PTC4 FLC2 1 Unpublished Fields Lab Data
    View Screen PTC4 PDX1 1 Unpublished Fields Lab Data
    View Screen PTC4 FET3 1 Unpublished Fields Lab Data
    View Screen PTC4 YBL100C 1 Unpublished Fields Lab Data
    View Screen PTC4 CBP2 1 Unpublished Fields Lab Data
    View Screen PTC4 YMR122C 1 Unpublished Fields Lab Data
    View Screen PTC4 POP4 1 Unpublished Fields Lab Data
    View Screen PTC4 VMA10 1 Unpublished Fields Lab Data
    View Screen PTC4 TMA23 1 Unpublished Fields Lab Data
    View Screen PTC4 PCA1 1 Unpublished Fields Lab Data
    View Screen PTC4 RPF1 1 Unpublished Fields Lab Data
    View Screen PTC4 TDA7 1 Unpublished Fields Lab Data
    View Screen PTC4 MXR2 1 Unpublished Fields Lab Data
    View Screen PTC4 RGI2 1 Unpublished Fields Lab Data
    View Screen PTC4 ATG4 1 Unpublished Fields Lab Data
    View Screen PTC4 SRO9 1 Unpublished Fields Lab Data
    View Screen PTC4 AIR1 1 Unpublished Fields Lab Data
    View Screen PTC4 RFC3 1 Unpublished Fields Lab Data
    View Screen PTC4 SHR3 1 Unpublished Fields Lab Data
    View Screen PTC4 RPL3 1 Unpublished Fields Lab Data
    View Screen PTC4 YOS9 1 Unpublished Fields Lab Data
    View Screen PTC4 XBP1 1 Unpublished Fields Lab Data
    View Screen PTC4 RPS12 1 Unpublished Fields Lab Data
    View Screen PTC4 PRM5 1 Unpublished Fields Lab Data
    View Screen PTC4 SUT2 1 Unpublished Fields Lab Data
    View Screen PTC4 SED1 1 Unpublished Fields Lab Data
    View Screen PTC4 DAL4 1 Unpublished Fields Lab Data
    View Screen SWI5 PTC4 1 Unpublished Fields Lab Data
    View Screen PTC4 ARP10 1 Unpublished Fields Lab Data
    View Screen PTC4 GSH1 1 Unpublished Fields Lab Data
    View Screen RPC19 PTC4 1 Unpublished Fields Lab Data
    View Screen PTC4 RPB7 1 Unpublished Fields Lab Data
    View Screen PTC4 YAK1 1 Unpublished Fields Lab Data
    View Screen PTC4 GRH1 1 Unpublished Fields Lab Data
    View Screen PTC4 BUD19 1 Unpublished Fields Lab Data
    View Screen PTC4 YEL028W 1 Unpublished Fields Lab Data
    View Screen PTC4 YIL172C, FSP2 1 Unpublished Fields Lab Data
    View Screen PTC4 GLO3 1 Unpublished Fields Lab Data
    View Screen PTC4 YLR111W 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PTC4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..393] PSI-BLAST 336.70927 Protein serine/threonine phosphatase 2C, C-terminal domain; Protein serine/threonine phosphatase 2C, catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.29765002420868 bayes_pls_golite062009
  • phosphatase activity
    		•  6.84540130415879 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.63839066304808 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  6.20846750257603 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.76293366458633 bayes_pls_golite062009
  • hydrolase activity
    		•  2.93014592649821 bayes_pls_golite062009
  • binding
    		•  1.74689317666387 bayes_pls_golite062009
  • signal transducer activity
    		•  1.61688496161233 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.61688496161233 bayes_pls_golite062009
  • catalytic activity
    		•  1.53401212718168 bayes_pls_golite062009
  • protein binding
    		•  1.47578617076714 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle