YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: PCA1

General Information:
Name(s) found: PCA1 / YBR295W [SGD]
Description(s) found:
Found 25 descriptions.
SHOW ALL
  • Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1216 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article]
    Biological Process: cellular iron ion homeostasis [IEPLink to PubMed article]
    cadmium ion transport [IGILink to PubMed article][IMPLink to PubMed article]
    cellular metal ion homeostasis [IMPLink to PubMed article]
    Molecular Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [ISSLink to PubMed article]
    copper ion binding [IMPLink to PubMed article]
    cadmium-exporting ATPase activity [IMPLink to PubMed articleLink to PubMed article]
    [NOT]copper-transporting ATPase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPEKLFSGL GTSDGEYGVV NSENISIDAM QDNRGECHRR SIEMHANDNL GLVSQRDCTN  60
   61 RPKITPQECL SETEQICHHG ENRTKAGLDV DDAETGGDHT NESRVDECCA EKVNDTETGL 120
  121 DVDSCCGDAQ TGGDHTNESC VDGCCVRDSS VMVEEVTGSC EAVSSKEQLL TSFEVVPSKS 180
  181 EGLQSIHDIR ETTRCNTNSN QHTGKGRLCI ESSDSTLKKR SCKVSRQKIE VSSKPECCNI 240
  241 SCVERIASRS CEKRTFKGST NVGISGSSST DSLSEKFFSE QYSRMYNRYS SILKNLGCIC 300
  301 NYLRTLGKES CCLPKVRFCS GEGASKKTKY SYRNSSGCLT KKKTHGDKER LSNDNGHADF 360
  361 VCSKSCCTKM KDCAVTSTIS GTSSSEISRI VSMEPIENHL NLEAGSTGTE HIVLSVSGMS 420
  421 CTGCESKLKK SFGALKCVHG LKTSLILSQA EFNLDLAQGS VKDVIKHLSK TTEFKYEQIS 480
  481 NHGSTIDVVV PYAAKDFINE EWPQGVTELK IVERNIIRIY FDPKVIGARD LVNEGWSVPV 540
  541 SIAPFSCHPT IEVGRKHLVR VGCTTALSII LTIPILVMAW APQLREKIST ISASMVLATI 600
  601 IQFVIAGPFY LNALKSLIFS RLIEMDLLIV LSTSAAYIFS IVSFGYFVVG RPLSTEQFFE 660
  661 TSSLLVTLIM VGRFVSELAR HRAVKSISVR SLQASSAILV DKTGKETEIN IRLLQYGDIF 720
  721 KVLPDSRIPT DGTVISGSSE VDEALITGES MPVPKKCQSI VVAGSVNGTG TLFVKLSKLP 780
  781 GNNTISTIAT MVDEAKLTKP KIQNIADKIA SYFVPTIIGI TVVTFCVWIA VGIRVEKQSR 840
  841 SDAVIQAIIY AITVLIVSCP CVIGLAVPIV FVIASGVAAK RGVIFKSAES IEVAHNTSHV 900
  901 VFDKTGTLTE GKLTVVHETV RGDRHNSQSL LLGLTEGIKH PVSMAIASYL KEKGVSAQNV 960
  961 SNTKAVTGKR VEGTSYSGLK LQGGNCRWLG HNNDPDVRKA LEQGYSVFCF SVNGSVTAVY1020
 1021 ALEDSLRADA VSTINLLRQR GISLHILSGD DDGAVRSMAA RLGIESSNIR SHATPAEKSE1080
 1081 YIKDIVEGRN CDSSSQSKRP VVVFCGDGTN DAIGLTQATI GVHINEGSEV AKLAADVVML1140
 1141 KPKLNNILTM ITVSQKAMFR VKLNFLWSFT YNLFAILLAA GAFVDFHIPP EYAGLGELVS1200
 1201 ILPVIFVAIL LRYAKI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) CDC28 CKS1 CLB3 CLN1 CLN2 DAL7 PCA1 SIC1 SRL3 YPL014W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..313] deduced N/A No confident structure predictions are available.
    2 View Details [314..389] PSI-BLAST 14.522879 Menkes copper-transporting ATPase
    3 View Details [390..456] deduced N/A Confident ab initio structure predictions are available.
    4 View Details [457..562] PSI-BLAST 14.39794 Potential copper-translocating P-type ATPase
    5 View Details [563..607]
    [696..796]    		 PSI-BLAST 125.529817 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
    6 View Details [608..685]
    [797..870]    		 PSI-BLAST 125.529817 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
    7 View Details [686..695]
    [871..937]    		 PSI-BLAST 125.529817 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
    8 View Details [938..1001] PSI-BLAST 6.39794 Phosphoserine phosphatase
    9 View Details [1002..1154] PSI-BLAST 6.39794 Phosphoserine phosphatase
    10 View Details [1155..1216] MSA 4.447996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • copper chaperone activity
    		•  9.82063669832995 bayes_pls_golite062009
  • copper-dependent protein binding
    		•  9.4886676850819 bayes_pls_golite062009
  • metallochaperone activity
    		•  8.74818422646376 bayes_pls_golite062009
  • superoxide dismutase copper chaperone activity
    		•  7.67724993505658 bayes_pls_golite062009
  • copper ion transmembrane transporter activity
    		•  6.91184156399207 bayes_pls_golite062009
  • copper ion binding
    		•  5.41725082570189 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  5.4007166857771 bayes_pls_golite062009
  • copper-exporting ATPase activity
    		•  5.04749761961029 bayes_pls_golite062009
  • copper-transporting ATPase activity
    		•  5.03252922496602 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  4.79570221435856 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  4.61622753861072 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.52484959112186 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  4.12792340516867 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  4.10264569844449 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  3.70964017127302 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
    		•  3.27250923701445 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  2.98847682261773 bayes_pls_golite062009
  • metal ion binding
    		•  2.69806984896689 bayes_pls_golite062009
  • cation binding
    		•  2.69806984896689 bayes_pls_golite062009
  • ion binding
    		•  2.69078950610234 bayes_pls_golite062009
  • transition metal ion binding
    		•  2.52520930681159 bayes_pls_golite062009
  • transporter activity
    		•  2.43435890488191 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.32163502360862 bayes_pls_golite062009
  • binding
    		•  2.31155280022787 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.28845421748925 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  1.62116507842838 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  1.61680623728503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  1.59572740343301 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  1.5925429451548 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  1.59219836319916 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.53883152283038 bayes_pls_golite062009
  • hydrolase activity
    		•  1.26149508477113 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.1718859439419 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.10705671028492 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.09044745388495 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.0880789970261 bayes_pls_golite062009
  • ATPase activity
    		•  1.08091411328281 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.02520458852568 bayes_pls_golite062009
  • protein binding
    		•  0.889287086236279 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.75722873989123 bayes_pls_golite062009
    5
    Term Confidence Notes
  • copper chaperone activity
    		•  9.82063669832995 bayes_pls_golite062009
  • copper-dependent protein binding
    		•  9.4886676850819 bayes_pls_golite062009
  • metallochaperone activity
    		•  8.74818422646376 bayes_pls_golite062009
  • superoxide dismutase copper chaperone activity
    		•  7.67724993505658 bayes_pls_golite062009
  • copper ion transmembrane transporter activity
    		•  6.91184156399207 bayes_pls_golite062009
  • copper ion binding
    		•  5.41725082570189 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  5.4007166857771 bayes_pls_golite062009
  • copper-exporting ATPase activity
    		•  5.04749761961029 bayes_pls_golite062009
  • copper-transporting ATPase activity
    		•  5.03252922496602 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  4.79570221435856 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  4.61622753861072 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.52484959112186 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  4.12792340516867 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  4.10264569844449 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  3.70964017127302 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
    		•  3.27250923701445 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  2.98847682261773 bayes_pls_golite062009
  • metal ion binding
    		•  2.69806984896689 bayes_pls_golite062009
  • cation binding
    		•  2.69806984896689 bayes_pls_golite062009
  • ion binding
    		•  2.69078950610234 bayes_pls_golite062009
  • transition metal ion binding
    		•  2.52520930681159 bayes_pls_golite062009
  • transporter activity
    		•  2.43435890488191 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.32163502360862 bayes_pls_golite062009
  • binding
    		•  2.31155280022787 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.28845421748925 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  1.62116507842838 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  1.61680623728503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  1.59572740343301 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  1.5925429451548 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  1.59219836319916 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.53883152283038 bayes_pls_golite062009
  • hydrolase activity
    		•  1.26149508477113 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.1718859439419 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.10705671028492 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.09044745388495 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.0880789970261 bayes_pls_golite062009
  • ATPase activity
    		•  1.08091411328281 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.02520458852568 bayes_pls_golite062009
  • protein binding
    		•  0.889287086236279 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.75722873989123 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle