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Protein Overview: XBP1

General Information:
Name(s) found: XBP1 / YIL101C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 647 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: response to stress [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKYPAFSINS DTVHLTDNPL DDYQRLYLVS VLDRDSPPAS FSAGLNIRKV NYKSSIAAQF  60
   61 THPNFIISAR DAGNGEEAAA QNVLNCFEYQ FPNLQTIQSL VHEQTLLSQL ASSATPHSAL 120
  121 HLHDKNILMG KIILPSRSNK TPVSASPTKQ EKKALSTASR ENATSSLTKN QQFKLTKMDH 180
  181 NLINDKLINP NNCVIWSHDS GYVFMTGIWR LYQDVMKGLI NLPRGDSVST SQQQFFCKAE 240
  241 FEKILSFCFY NHSSFTSEES SSVLLSSSTS SPPKRRTSTG STFLDANASS SSTSSTQANN 300
  301 YIDFHWNNIK PELRDLICQS YKDFLINELG PDQIDLPNLN PANFTKRIRG GYIKIQGTWL 360
  361 PMEISRLLCL RFCFPIRYFL VPIFGPDFPK DCESWYLAHQ NVTFASSTTG AGAATAATAA 420
  421 ANTSTNFTST AVARPRQKPR PRPRQRSTSM SHSKAQKLVI EDALPSFDSF VENLGLSSND 480
  481 KNFIKKNSKR QKSSTYTSQT SSPIGPRDPT VQILSNLASF YNTHGHRYSY PGNIYIPQQR 540
  541 YSLPPPNQLS SPQRQLNYTY DHIHPVPSQY QSPRHYNVPS SPIAPAPPTF PQPYGDDHYH 600
  601 FLKYASEVYK QQNQRPAHNT NTNMDTSFSP RANNSLNNFK FKTNSKQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) SNT2 XBP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen BNI1 XBP1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data XBP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..114]
    [222..254]
    [282..399]
    [456..495]    		 ORFEUS 7.03 Adenovirus hexon
    2 View Details [115..221]
    [255..281]
    [400..455]
    [496..647]    		 ORFEUS 7.03 Adenovirus hexon
    3 View Details [442..647] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.1591777721979 bayes_pls_golite062009
  • DNA binding
    		•  1.61369890668807 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.45716149387929 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.809468114799958 bayes_pls_golite062009
  • transcription factor activity
    		•  0.590391518925168 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.25989279929812 bayes_pls_golite062009
  • protein binding
    		•  0.249603995881649 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle