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View Structure Prediction Details

Protein: XBP1
Organism: Saccharomyces cerevisiae
Length: 647 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for XBP1.

Description E-value Query
Range
Subject
Range
XBP1 - Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expr...
XBP1_YEAST - Transcriptional repressor XBP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=XBP1 PE=1...
0.0 [1..647] [1..647]

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Predicted Domain #1
Region A:
Residues: [1-114]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKYPAFSINS DTVHLTDNPL DDYQRLYLVS VLDRDSPPAS FSAGLNIRKV NYKSSIAAQF  60
   61 THPNFIISAR DAGNGEEAAA QNVLNCFEYQ FPNLQTIQSL VHEQTLLSQL ASSA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [222-254]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPRGDSVSTS QQQFFCKAEF EKILSFCFYN HSS

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [282-399]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TFLDANASSS STSSTQANNY IDFHWNNIKP ELRDLICQSY KDFLINELGP DQIDLPNLNP  60
   61 ANFTKRIRGG YIKIQGTWLP MEISRLLCLR FCFPIRYFLV PIFGPDFPKD CESWYLAH

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [456-495]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKLVIEDALP SFDSFVENLG LSSNDKNFIK KNSKRQKSST 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.03
Match: 1ruxA
Description: Adenovirus hexon

Predicted Domain #2
Region A:
Residues: [115-221]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPHSALHLHD KNILMGKIIL PSRSNKTPVS ASPTKQEKKA LSTASRENAT SSLTKNQQFK  60
   61 LTKMDHNLIN DKLINPNNCV IWSHDSGYVF MTGIWRLYQD VMKGLIN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [255-281]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTSEESSSVL LSSSTSSPPK RRTSTGS

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [400-455]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QNVTFASSTT GAGAATAATA AANTSTNFTS TAVARPRQKP RPRPRQRSTS MSHSKA

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [496-647]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTSQTSSPIG PRDPTVQILS NLASFYNTHG HRYSYPGNIY IPQQRYSLPP PNQLSSPQRQ  60
   61 LNYTYDHIHP VPSQYQSPRH YNVPSSPIAP APPTFPQPYG DDHYHFLKYA SEVYKQQNQR 120
  121 PAHNTNTNMD TSFSPRANNS LNNFKFKTNS KQ

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.03
Match: 1ruxA
Description: Adenovirus hexon

Predicted functions:

Term Confidence Notes
binding 2.1591777721979 bayes_pls_golite062009
DNA binding 1.61369890668807 bayes_pls_golite062009
nucleic acid binding 1.45716149387929 bayes_pls_golite062009
transcription regulator activity 0.809468114799958 bayes_pls_golite062009
transcription factor activity 0.590391518925168 bayes_pls_golite062009
sequence-specific DNA binding 0.25989279929812 bayes_pls_golite062009
protein binding 0.249603995881649 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [442-647]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPRQRSTSMS HSKAQKLVIE DALPSFDSFV ENLGLSSNDK NFIKKNSKRQ KSSTYTSQTS  60
   61 SPIGPRDPTV QILSNLASFY NTHGHRYSYP GNIYIPQQRY SLPPPNQLSS PQRQLNYTYD 120
  121 HIHPVPSQYQ SPRHYNVPSS PIAPAPPTFP QPYGDDHYHF LKYASEVYKQ QNQRPAHNTN 180
  181 TNMDTSFSPR ANNSLNNFKF KTNSKQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle