Protein Overview: DYN1

General Information:
Name(s) found:	DYN1 / YKR054C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6322907\|ref\|NP_012980.1\| Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips [NCBI NR] gi\|544197\|sp\|P36022.1\|DYHC_YEAST RecName: Full=Dynein heavy chain, cytoplasmic; AltName: Full=Dynein heavy chain, cytosolic; Short=DYHC [NCBI NR] pir\|\|S38128 dynein heavy chain, cytosolic - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|486511\|emb\|CAA82132.1\| DYN1 [Saccharomyces cerevisiae] [NCBI NR] Dynein heavy chain, cytoplasmic OS=Saccharomyces cerevisiae GN=DYN1 PE=1 SV=1 [Swiss-Prot] DYN1 Dynein heavy chain, cytosolic [mips] Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p [SGD] DYN1, Chr XI from 535284-547562, reverse complement [yeast_orfs2] Chr XI from 535284-547562, reverse complement [yeastorf3.fasta] Chr XI from 547562-535284, reverse complement [yeastorf5.fasta] (P36022) Dynein heavy chain, cytosolic (DYHC) [4932.FASTACCERV.txt] DYN1 SGDID:S0001762, Chr XI from 547567-535289, reverse complement, Verified ORF [yeastflysequest.fasta] Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p [Saccharomyces cere [nrdb_11152004_Chlamydomonas] DYN1 SGDID:S000001762, Chr XI from 547567-535289, reverse complement, Verified ORF, "Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orient [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Dynein heavy chain, cytosolic (DYHC) [nr-271106-contam.fasta] Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; Dyn1p [Saccharomyc [nr-271106-contam.fasta] DYN1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] DYN1 SGDID:S000001762, Chr XI from 547567-535289, reverse complement, Verified ORF, "Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Dynein heavy chain, cytoplasmic OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DYN1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] DYN1 SGDID:S000001762, Chr XI from 547925-535647, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p" [yeast-030211-contam.fasta] DYN1 SGDID:S000001762, Chr XI from 547925-535647, Genome Release 64-2-1, reverse complement, Verified ORF, "Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p" [20141208_orf_trans.fasta] YKR054C SGDID:S000001762, Chr XI from 547925-535647, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	4092 amino acids
Gene Ontology:
Cellular Component:	cytoplasmic dynein complex [TAS] cytoplasmic microtubule [IDA][TAS]
Biological Process:	mitotic spindle elongation [TAS] establishment of mitotic spindle orientation [IGI][IMP] mitotic sister chromatid segregation [TAS] nuclear migration along microtubule [TAS]
Molecular Function:	motor activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
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    1 MCKNEARLAN ELIEFVAATV TGIKNSPKEN EQAFIDYLHC QYLERFQFFL GLLDGREFDT  60
   61 LFVFLFEELD RTIVTIDIGE EAIYDANLAN KKYSTLLIIK SRSVIVDAEP IATQISAIYL 120
  121 PGPVNAGNLA SIITHGVSSV FGQLIKSDTK TYSVETIDKT RRKLDDISKQ FQQLHTSIET 180
  181 PDLLAMVPSI IKLAVSKGAT SHDYANYLPS NDLESMRFLN ILQSIANKWF LVLKQTLAID 240
  241 RDIKNGSFLD EVEFWSNFYE VLKSLIEQTQ SQEFQVCLSV LTNAKRFHNL TNLLNEGSLS 300
  301 DKFKLADKYN QFLSSIPIDE VRQASNLEDL QELFPVLASS LKKFRYSGYP VQRFVVLMDK 360
  361 ISQEVMDAIL SNLSDLFQLE YGSFLGLYEK SAGMIEEWDD IVQDVNLLIR EDLRKRAPQE 420
  421 LLIQKLTFTS ASVKATLDEI LSTRKRFFSL AETIKSISPS TYHEEIQRLY HPFEQIHDIS 480
  481 VNFRLKLEQA ESEFSKNMLD LEKKLQNTLA SFMDSDHCPT EKLSYLVKFK PLMELCPRIK 540
  541 VKVLENQQIL LLEIKKDIRQ LETGLELLPK ILHVEALNNI PPISARISYF LNVQSRIDNI 600
  601 VQYLEALFGS NWNDTLEGRS ISTSIVQLRK ETNPHDVFLH WLGNFPEKAT ANLLTTPILK 660
  661 LIRNNEDDYE LKVNFDFALA AAYSELRSLT YMAFQVPSHI VRIARTYMYL YPRAINLVEL 720
  721 IQTFFSLSKS LSYTFYTNIF LKRNVQTVWL LLQQILITPW ESLQEESSEM SCSVHSLARL 780
  781 EKSIDGILSD YQILKNSEPQ FAKEFSGLKS FDGTADDLHE VEEIISNIQA IFENLFTKGL 840
  841 TNVSDHISTF NNLIISIILE KVRLNLKKMH FPKHVLKLSF NEGRITSSPS LAAMKRSLLK 900
  901 DIEALLNKVV LINFLHDPDH PLSTTLTFNS LVIKLKDDIQ NCIEQVQNLH CKINSYVKEW 960
  961 QKMEFLWQIT EEAFLEVVDN STQRCFGILK GLLDSQSKFD LIISRNNFSK NLVLHTEDAQ1020
 1021 RHIRSKMDSW ILYVSKHLLT IYERDARKLH EDMNRDREAV EDMDINFTSL KNITVIIEAV1080
 1081 NVNKRHLTER DIQIKLLGSV MRALTKLKVR FPSHFVYIDQ LDNDFSSLRQ SLSYVEQELQ1140
 1141 KHRVVIAKSL EEGVENINNL SQSLNESWSV RKPISPTLTP PEALKILEFF NESITKLKKK1200
 1201 MHSVAAAAKM LLIPVVLNDQ LTHVVEEVKT YDLVWRSIKN LWEDVQRTFE TPWCRVDVLL1260
 1261 LQSDLANFLR RADELPRAVK QFEMYKSLFS QVNMLTSVNK ILVELKDGAL KPRHWNMIFR1320
 1321 DIGKRQIQKN LLDKLEFSLK DVMVLNLTLN EILLTKIIER AQKEFVIEKS LNRIKKFWKE1380
 1381 AQYEVIEHSS GLKLVREWDV LEQACKEDLE ELVSMKASNY YKIFEQDCLD LESKLTKLSE1440
 1441 IQVNWVEVQF YWLDLYGILG ENLDIQNFLP LETSKFKSLT SEYKMITTRA FQLDTTIEVI1500
 1501 HIPNFDTTLK LTIDSLKMIK SSLSTFLERQ RRQFPRFYFL GNDDLLKIIG SGKHHDQVSK1560
 1561 FMKKMFGSIE SIIFLEDFIT GVRSVEGEVL NLNEKIELKD SIQAQEWLNI LDTEIKLSVF1620
 1621 TQFRDCLGQL KDGTDIEVVV SKYIFQAILL SAQVMWTELV EKCLQTNQFS KYWKEVDMKI1680
 1681 KGLLDKLNKS SDNVKKKIEA LLVEYLHFNN VIGQLKNCST KEEARLLWAK VQKFYQKNDT1740
 1741 LDDLNSVFIS QSGYLLQYKF EYIGIPERLI YTPLLLIGFA TLTDSLHQKY GGCFFGPAGT1800
 1801 GKTETVKAFG QNLGRVVVVF NCDDSFDYQV LSRLLVGITQ IGAWGCFDEF NRLDEKVLSA1860
 1861 VSANIQQIQN GLQVGKSHIT LLEEETPLSP HTAVFITLNP GYNGRSELPE NLKKSFREFS1920
 1921 MKSPQSGTIA EMILQIMGFE DSKSLASKIV HFLELLSSKC SSMNHYHFGL RTLKGVLRNC1980
 1981 SPLISEFGEG EKTVVESLKR VILPSLGDTD ELVFKDELSK IFDSAGTPLN SKAIVQCLKD2040
 2041 AGQRSGFSMS EEFLKKCMQF YYMQKTQQAL ILVGKAGCGK TATWKTVIDA MAIFDGHANV2100
 2101 VYVIDTKVLT KESLYGSMLK ATLEWRDGLF TSILRRVNDD ITGTFKNSRI WVVFDSDLDP2160
 2161 EYVEAMNSVL DDNKILTLPN GERLPIPPNF RILFETDNLD HTTPATITRC GLLWFSTDVC2220
 2221 SISSKIDHLL NKSYEALDNK LSMFELDKLK DLISDSFDMA SLTNIFTCSN DLVHILGVRT2280
 2281 FNKLETAVQL AVHLISSYRQ WFQNLDDKSL KDVITLLIKR SLLYALAGDS TGESQRAFIQ2340
 2341 TINTYFGHDS QELSDYSTIV IANDKLSFSS FCSEIPSVSL EAHEVMRPDI VIPTIDTIKH2400
 2401 EKIFYDLLNS KRGIILCGPP GSGKTMIMNN ALRNSSLYDV VGINFSKDTT TEHILSALHR2460
 2461 HTNYVTTSKG LTLLPKSDIK NLVLFCDEIN LPKLDKYGSQ NVVLFLRQLM EKQGFWKTPE2520
 2521 NKWVTIERIH IVGACNPPTD PGRIPMSERF TRHAAILYLG YPSGKSLSQI YEIYYKAIFK2580
 2581 LVPEFRSYTE PFARASVHLY NECKARYSTG LQSHYLFSPR ELTRLVRGVY TAINTGPRQT2640
 2641 LRSLIRLWAY EAWRIFADRL VGVKEKNSFE QLLYETVDKY LPNQDLGNIS STSLLFSGLL2700
 2701 SLDFKEVNKT DLVNFIEERF KTFCDEELEV PMVIHESMVD HILRIDRALK QVQGHMMLIG2760
 2761 ASRTGKTILT RFVAWLNGLK IVQPKIHRHS NLSDFDMILK KAISDCSLKE SRTCLIIDES2820
 2821 NILETAFLER MNTLLANADI PDLFQGEEYD KLLNNLRNKT RSLGLLLDTE QELYDWFVGE2880
 2881 IAKNLHVVFT ICDPTNNKSS AMISSPALFN RCIINWMGDW DTKTMSQVAN NMVDVIPMEF2940
 2941 TDFIVPEVNK ELVFTEPIQT IRDAVVNILI HFDRNFYQKM KVGVNPRSPG YFIDGLRALV3000
 3001 KLVTAKYQDL QENQRFVNVG LEKLNESVLK VNELNKTLSK KSTELTEKEK EARSTLDKML3060
 3061 MEQNESERKQ EATEEIKKIL KVQEEDIRKR KEVVMKSIQD IEPTILEAQR GVKNIKKQQL3120
 3121 TEIRSMVNPP SGVKIVMEAV CAILGYQFSN WRDIQQFIRK DDFIHNIVHY DTTLHMKPQI3180
 3181 RKYMEEEFLS DPNFTYETIN RASKACGPLY QWVNAQINFS KVLENVDPLR QEMKRIEFES3240
 3241 LKTKANLLAA EEMTQDLEAS IEVSKRKYSL LIRDVEAIKT EMSNVQANLD RSISLVKSLT3300
 3301 FEKERWLNTT KQFSKTSQEL IGNCIISSIY ETYFGHLNER ERADMLVILK RLLGKFAVKY3360
 3361 DVNYRFIDYL VTLDEKMKWL ECGLDKNDYF LENMSIVMNS QDAVPFLLDP SSHMITVISN3420
 3421 YYGNKTVLLS FLEEGFVKRL ENAIRFGSVV IIQDGEFFDP IISRLISREF NHAGNRVTVE3480
 3481 IGDHEVDVSG DFKLFIHSCD PSGDIPIFLR SRVRLVHFVT NKESIETRIF DITLTEENAE3540
 3541 MQRKREDLIK LNTEYKLKLK NLEKRLLEEL NNSQGNMLEN DELMVTLNNL KKEAMNIEKK3600
 3601 LSESEEFFPQ FDNLVEEYSI IGKHSVKIFS MLEKFGQFHW FYGISIGQFL SCFKRVFIKK3660
 3661 SRETRAARTR VDEILWLLYQ EVYCQFSTAL DKKFKMIMAM TMFCLYKFDI ESEQYKEAVL3720
 3721 TMIGVLSESS DGVPKLTVDT NNDLRYLWDY VTTKSYISAL NWFKNEFFVD EWNIADVVAN3780
 3781 SENNYFTMAS ERDVDGTFKL IELAKASKES LKIIPLGSIE NLNYAQEEIS KSKIEGGWIL3840
 3841 LQNIQMSLSW VKTYLHKHVE ETKAAEEHEK FKMFMTCHLT GDKLPAPLLQ RTDRFVYEDI3900
 3901 PGILDTVKDL WGSQFFTGKI SGVWSVYCTF LLSWFHALIT ARTRLVPHGF SKKYYFNDCD3960
 3961 FQFASVYLEN VLATNSTNNI PWAQVRDHIA TIVYGGKIDE EKDLEVVAKL CAHVFCGSDN4020
 4021 LQIVPGVRIP QPLLQQSEEE ERARLTAILS NTIEPADSLS SWLQLPRESI LNYERLQAKE4080
 4081 VASSTEQLLQ EM

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		AME1 ARP1 BIK1 CIK1 DYN1 DYN2 JNM1 KAR3 KAR5 NUF2 PAC11 SPC19 SPC34 STU1 STU2 TID3
View Details	Krogan NJ, et al. (2006)		DYN1 KEL3 YRO2
View Details	Gavin AC, et al. (2002)		BDF2 CDC55 CKB1 DYN1 ECM5 GLY1 HAT1 HAT2 HHF1, HHF2 HIF1 HSM3 ICL1 IML1 KAP123 KRE33 LIP2 MAC1 MDN1 MIS1 MSB1 NIP1 NMD5 PFK1 PRO1 PRT1 PSD2 PSE1 PSH1 RPA135 RPC40 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT5 RPT6 RSC3 SAM1 TEL1 TSC11 USO1 UTP20 VTH2 YFR006W YPR077C
View Details	Qiu et al. (2008)		AME1 ARP1 BIK1 CIK1 DYN1 DYN2 DYN3 JNM1 KAR3 KIP2 KIP3 MHP1 MYO2 MYO3 MYO5 NIP100 NUF2 NUM1 PAC1 PAC11 STU1 STU2 TID3 TUB1 VIK1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	PAN1	No Comments	Toshima J, et al (2006)
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	ZDS1	Sample 3 - cpn + atp, from june 2005	McCusker D, et al (2007)
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2	Keck JM, et al. (2011)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#04 Alpha Factor Prep2	Keck JM, et al. (2011)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#10 Mitotic Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	EUG1	DYN1	1	Unpublished Fields Lab Data
View Screen	TIM50	DYN1	1	Hazbun TR, et al. (2003)
View Screen	CDC13	DYN1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	DYN1	Huh WK, et al. (2003)

Protein Structure Data

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted