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Protein Overview: HSL1

General Information:
Name(s) found: HSL1 / YKL101W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1518 amino acids

    Gene Ontology:
    Cellular Component: cellular bud neck [IDALink to PubMed articleLink to PubMed article]
    septin ring [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: cell morphogenesis checkpoint [TASLink to PubMed article]
    G2/M transition of mitotic cell cycle [IGILink to PubMed article][IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    septin checkpoint [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: protein kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGHVSKTSH VPKGRPSSLA KKAAKRAMAK VNSNPKRASG HLERVVQSVN DATKRLSQPD  60
   61 STVSVATKSS KRKSRDTVGP WKLGKTLGKG SSGRVRLAKN METGQLAAIK IVPKKKAFVH 120
  121 CSNNGTVPNS YSSSMVTSNV SSPSIASREH SNHSQTNPYG IEREIVIMKL ISHTNVMALF 180
  181 EVWENKSELY LVLEYVDGGE LFDYLVSKGK LPEREAIHYF KQIVEGVSYC HSFNICHRDL 240
  241 KPENLLLDKK NRRIKIADFG MAALELPNKL LKTSCGSPHY ASPEIVMGRP YHGGPSDVWS 300
  301 CGIVLFALLT GHLPFNDDNI KKLLLKVQSG KYQMPSNLSS EARDLISKIL VIDPEKRITT 360
  361 QEILKHPLIK KYDDLPVNKV LRKMRKDNMA RGKSNSDLHL LNNVSPSIVT LHSKGEIDES 420
  421 ILRSLQILWH GVSRELITAK LLQKPMSEEK LFYSLLLQYK QRHSISLSSS SENKKSATES 480
  481 SVNEPRIEYA SKTANNTGLR SENNDVKTLH SLEIHSEDTS TVNQNNAITG VNTEINAPVL 540
  541 AQKSQFSINT LSQPESDKAE AEAVTLPPAI PIFNASSSRI FRNSYTSISS RSRRSLRLSN 600
  601 SRLSLSASTS RETVHDNEMP LPQLPKSPSR YSLSRRAIHA SPSTKSIHKS LSRKNIAATV 660
  661 AARRTLQNSA SKRSLYSLQS ISKRSLNLND LLVFDDPLPS KKPASENVNK SEPHSLESDS 720
  721 DFEILCDQIL FGNALDRILE EEEDNEKERD TQRQRQNDTK SSADTFTISG VSTNKENEGP 780
  781 EYPTKIEKNQ FNMSYKPSEN MSGLSSFPIF EKENTLSSSY LEEQKPKRAA LSDITNSFNK 840
  841 MNKQEGMRIE KKIQREQLQK KNDRPSPLKP IQHQELRVNS LPNDQGKPSL SLDPRRNISQ 900
  901 PVNSKVESLL QGLKFKKEPA SHWTHERGSL FMSEHVEDEK PVKASDVSIE SSYVPLTTVA 960
  961 TSSRDPSVLA ESSTIQKPML SLPSSFLNTS MTFKNLSQIL ADDGDDKHLS VPQNQSRSVA1020
 1021 MSHPLRKQSA KISLTPRSNL NANLSVKRNQ GSPGSYLSND LDGISDMTFA MEIPTNTFTA1080
 1081 QAIQLMNNDT DNNKINTSPK ASSFTKEKVI KSAAYISKEK EPDNSDTNYI PDYTIPNTYD1140
 1141 EKAINIFEDA PSDEGSLNTS SSESDSRASV HRKAVSIDTM ATTNVLTPAT NVRVSLYWNN1200
 1201 NSSGIPRETT EEILSKLRLS PENPSNTHMQ KRFSSTRGSR DSNALGISQS LQSMFKDLEE1260
 1261 DQDGHTSQAD ILESSMSYSK RRPSEESVNP KQRVTMLFDE EEEESKKVGG GKIKEEHTKL1320
 1321 DNKISEESSQ LVLPVVEKKE NANNTENNYS KIPKPSTIKV TKDTAMESNT QTHTKKPILK1380
 1381 SVQNVEVEEA PSSDKKNWFV KLFQNFSSHN NATKASKNHV TNISFDDAHM LTLNEFNKNS1440
 1441 IDYQLKNLDH KFGRKVVEYD CKFVKGNFKF KIKITSTPNA SSVITVKKRS KHSNTSSNKA1500
 1501 FEKFNDDVER VIRNAGRS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BCY1 CHK1 HSL1 TPK1 TPK2
    View Details Gavin AC, et al. (2006) CAM1 HSL1 RAD34
    View Details Gavin AC, et al. (2002) ADE4 ASC1 BFR2 BMS1 BRX1 BUD21 CBF5 CFT2 CKA1 CKA2 CKB1 CKB2 CMS1 DBP8 DIA4 DIM1 DIP2 DIS3 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HSL1 HTA2 IMP3 IMP4 KRE33 KRR1 LCP5 LTV1 MPP10 MRD1 MVD1 NAN1 NOB1 NOC2 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 PAP1 PFS2 PNO1 PRE6 PRE9 PRP43 PTA1 PTI1 PWP2 RCL1 REF2 RML2 RNA14 ROK1 RPP2B RRP12 RRP7 RRP9 RTG2 SAM1 SCL1 SEC21 SLX9 SOF1 SRO9 TIF1, TIF2 TSR1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YOR059C YSH1
    View Details Qiu et al. (2008) ELM1 GIN4 HSL1 SWE1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen KAP104 HSL1 1 Unpublished Fields Lab Data
    View Screen APC5 HSL1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HSL1 Sundin BA, et al. (2004)
    View Data HSL1 Sundin BA, et al. (2004)
    View Data HSL1 Sundin BA, et al. (2004)
    View Data HSL1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..198]
    [392..408]    		 PSI-BLAST 579.0103 Calmodulin-dependent protein kinase
    2 View Details [199..391] PSI-BLAST 579.0103 Calmodulin-dependent protein kinase
    3 View Details [409..500] PSI-BLAST 11.0 Calmodulin
    4 View Details [501..577] PSI-BLAST 11.0 Calmodulin
    5 View Details [578..671] deduced N/A No confident structure predictions are available.
    6 View Details [672..821] ORFEUS 9.74 RBP1
    7 View Details [822..997] ORFEUS 10.41 EGF receptor extracellular domain; EGF receptor Cys-rich domains
    8 View Details [998..1355] ORFEUS 10.41 EGF receptor extracellular domain; EGF receptor Cys-rich domains
    9 View Details [1356..1518] deduced N/A No confident structure predictions are available.
    10 View Details [1354..1518] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle