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View Structure Prediction Details

Protein: HSL1
Organism: Saccharomyces cerevisiae
Length: 1518 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HSL1.

Description E-value Query
Range
Subject
Range
HSL1 - Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates wit...
0.0 [1..1518] [1..1518]
MARK2_RAT - Serine/threonine-protein kinase MARK2 OS=Rattus norvegicus GN=Mark2 PE=1 SV=1
0.0 [23..732] [3..675]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [22..570] [1..512]
gi|18175903 - gi|18175903|gb|AAL59948.1| putative calcium-dependent protein kinase [Arabidopsis thaliana]
0.0 [29..571] [21..520]
gi|14029712 - gi|14029712|gb|AAK52801.1|AF363784_1 calcium-dependent protein kinase CDPK1 [Lycopersicon esculentum...
0.0 [43..570] [35..519]
gi|13561063 - gi|13561063|emb|CAA65500.1| protein kinase [Medicago sativa]
0.0 [30..570] [37..540]

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Predicted Domain #1
Region A:
Residues: [1-198]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGHVSKTSH VPKGRPSSLA KKAAKRAMAK VNSNPKRASG HLERVVQSVN DATKRLSQPD  60
   61 STVSVATKSS KRKSRDTVGP WKLGKTLGKG SSGRVRLAKN METGQLAAIK IVPKKKAFVH 120
  121 CSNNGTVPNS YSSSMVTSNV SSPSIASREH SNHSQTNPYG IEREIVIMKL ISHTNVMALF 180
  181 EVWENKSELY LVLEYVDG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [392-408]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKSNSDLHLL NNVSPSI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 579.0103
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [199-391]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GELFDYLVSK GKLPEREAIH YFKQIVEGVS YCHSFNICHR DLKPENLLLD KKNRRIKIAD  60
   61 FGMAALELPN KLLKTSCGSP HYASPEIVMG RPYHGGPSDV WSCGIVLFAL LTGHLPFNDD 120
  121 NIKKLLLKVQ SGKYQMPSNL SSEARDLISK ILVIDPEKRI TTQEILKHPL IKKYDDLPVN 180
  181 KVLRKMRKDN MAR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 579.0103
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [409-500]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTLHSKGEID ESILRSLQIL WHGVSRELIT AKLLQKPMSE EKLFYSLLLQ YKQRHSISLS  60
   61 SSSENKKSAT ESSVNEPRIE YASKTANNTG LR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.0
Match: 1ahr__
Description: Calmodulin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [501-577]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SENNDVKTLH SLEIHSEDTS TVNQNNAITG VNTEINAPVL AQKSQFSINT LSQPESDKAE  60
   61 AEAVTLPPAI PIFNASS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.0
Match: 1ahr__
Description: Calmodulin
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [578-671]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRIFRNSYTS ISSRSRRSLR LSNSRLSLSA STSRETVHDN EMPLPQLPKS PSRYSLSRRA  60
   61 IHASPSTKSI HKSLSRKNIA ATVAARRTLQ NSAS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [672-821]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRSLYSLQSI SKRSLNLNDL LVFDDPLPSK KPASENVNKS EPHSLESDSD FEILCDQILF  60
   61 GNALDRILEE EEDNEKERDT QRQRQNDTKS SADTFTISGV STNKENEGPE YPTKIEKNQF 120
  121 NMSYKPSENM SGLSSFPIFE KENTLSSSYL 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.74
Match: 1k83A
Description: RBP1
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [822-997]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEQKPKRAAL SDITNSFNKM NKQEGMRIEK KIQREQLQKK NDRPSPLKPI QHQELRVNSL  60
   61 PNDQGKPSLS LDPRRNISQP VNSKVESLLQ GLKFKKEPAS HWTHERGSLF MSEHVEDEKP 120
  121 VKASDVSIES SYVPLTTVAT SSRDPSVLAE SSTIQKPMLS LPSSFLNTSM TFKNLS

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.41
Match: 1ivoA
Description: EGF receptor extracellular domain; EGF receptor Cys-rich domains
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [998-1355]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QILADDGDDK HLSVPQNQSR SVAMSHPLRK QSAKISLTPR SNLNANLSVK RNQGSPGSYL  60
   61 SNDLDGISDM TFAMEIPTNT FTAQAIQLMN NDTDNNKINT SPKASSFTKE KVIKSAAYIS 120
  121 KEKEPDNSDT NYIPDYTIPN TYDEKAINIF EDAPSDEGSL NTSSSESDSR ASVHRKAVSI 180
  181 DTMATTNVLT PATNVRVSLY WNNNSSGIPR ETTEEILSKL RLSPENPSNT HMQKRFSSTR 240
  241 GSRDSNALGI SQSLQSMFKD LEEDQDGHTS QADILESSMS YSKRRPSEES VNPKQRVTML 300
  301 FDEEEEESKK VGGGKIKEEH TKLDNKISEE SSQLVLPVVE KKENANNTEN NYSKIPKP

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.41
Match: 1ivoA
Description: EGF receptor extracellular domain; EGF receptor Cys-rich domains
Matching Structure (courtesy of the PDB):

Predicted Domain #9
Region A:
Residues: [1356-1518]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STIKVTKDTA MESNTQTHTK KPILKSVQNV EVEEAPSSDK KNWFVKLFQN FSSHNNATKA  60
   61 SKNHVTNISF DDAHMLTLNE FNKNSIDYQL KNLDHKFGRK VVEYDCKFVK GNFKFKIKIT 120
  121 STPNASSVIT VKKRSKHSNT SSNKAFEKFN DDVERVIRNA GRS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1354-1518]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPSTIKVTKD TAMESNTQTH TKKPILKSVQ NVEVEEAPSS DKKNWFVKLF QNFSSHNNAT  60
   61 KASKNHVTNI SFDDAHMLTL NEFNKNSIDY QLKNLDHKFG RKVVEYDCKF VKGNFKFKIK 120
  121 ITSTPNASSV ITVKKRSKHS NTSSNKAFEK FNDDVERVIR NAGRS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle