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Protein Overview: RET1

General Information:
Name(s) found: RET1 / YOR207C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1149 amino acids

    Gene Ontology:
    Cellular Component: DNA-directed RNA polymerase III complex [TASLink to PubMed article]
    Biological Process: transcription from RNA polymerase III promoter [TAS]
    Molecular Function: DNA-directed RNA polymerase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVAATKRRKT HIHKHVKDEA FDDLLKPVYK GKKLTDEINT AQDKWHLLPA FLKVKGLVKQ  60
   61 HLDSFNYFVD TDLKKIIKAN QLILSDVDPE FYLKYVDIRV GKKSSSSTKD YLTPPHECRL 120
  121 RDMTYSAPIY VDIEYTRGRN IIMHKDVEIG RMPIMLRSNK CILYDADESK MAKLNECPLD 180
  181 PGGYFIVNGT EKVILVQEQL SKNRIIVEAD EKKGIVQASV TSSTHERKSK TYVITKNGKI 240
  241 YLKHNSIAEE IPIAIVLKAC GILSDLEIMQ LVCGNDSSYQ DIFAVNLEES SKLDIYTQQQ 300
  301 ALEYIGAKVK TMRRQKLTIL QEGIEAIATT VIAHLTVEAL DFREKALYIA MMTRRVVMAM 360
  361 YNPKMIDDRD YVGNKRLELA GQLISLLFED LFKKFNNDFK LSIDKVLKKP NRAMEYDALL 420
  421 SINVHSNNIT SGLNRAISTG NWSLKRFKME RAGVTHVLSR LSYISALGMM TRISSQFEKS 480
  481 RKVSGPRALQ PSQFGMLCTA DTPEGEACGL VKNLALMTHI TTDDEEEPIK KLCYVLGVED 540
  541 ITLIDSASLH LNYGVYLNGT LIGSIRFPTK FVTQFRHLRR TGKVSEFISI YSNSHQMAVH 600
  601 IATDGGRICR PLIIVSDGQS RVKDIHLRKL LDGELDFDDF LKLGLVEYLD VNEENDSYIA 660
  661 LYEKDIVPSM THLEIEPFTI LGAVAGLIPY PHHNQSPRNT YQCAMGKQAI GAIAYNQFKR 720
  721 IDTLLYLMTY PQQPMVKTKT IELIDYDKLP AGQNATVAVM SYSGYDIEDA LVLNKSSIDR 780
  781 GFGRCETRRK TTTVLKRYAN HTQDIIGGMR VDENGDPIWQ HQSLGPDGLG EVGMKVQSGQ 840
  841 IYINKSVPTN SADAPNPNNV NVQTQYREAP VIYRGPEPSH IDQVMMSVSD NDQALIKVLL 900
  901 RQNRRPELGD KFSSRHGQKG VCGIIVKQED MPFNDQGIVP DIIMNPHGFP SRMTVGKMIE 960
  961 LISGKAGVLN GTLEYGTCFG GSKLEDMSKI LVDQGFNYSG KDMLYSGITG ECLQAYIFFG1020
 1021 PIYYQKLKHM VLDKMHARAR GPRAVLTRQP TEGRSRDGGL RLGEMERDCV IAYGASQLLL1080
 1081 ERLMISSDAF EVDVCDKCGL MGYSGWCTTC KSAENIIKMT IPYAAKLLFQ ELLSMNIAPR1140
 1141 LRLEDIFQQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ISW1 RET1 RPA135 RPA190 RPA49 RPB10 RPB5 RPB8 RPC11 RPC17 RPC19 RPC25 RPC31 RPC34 RPC37 RPC40 RPC53 RPC82 RPO26 RPO31
    View Details (MIPS) Mewes HW, et al. (2004) RET1 RPB10 RPB5 RPB8 RPC10 RPC19 RPC25 RPC31 RPC34 RPC40 RPC82 RPO26 RPO31
    View Details Krogan NJ, et al. (2006) BDP1 CDC14 COY1 FAR7 MAF1 RET1 RPA12 RPA135 RPA14 RPA190 RPA34 RPA43 RPA49 RPC10 RPC11 RPC17 RPC19 RPC25 RPC31 RPC34 RPC37 RPC40 RPC53 RPC82 RPO31 YDL144C YIR024C
    View Details Gavin AC, et al. (2006) RET1 RPC25 RPC31 RPC34 RPC37 RPC40 RPC53 RPC82 RPO31
    View Details Gavin AC, et al. (2002) AMS1 ASC1 CAB3 CDC14 CHD1 CKA1 CKA2 CKB1 CKB2 DHH1 DPB2 DPB4 FBA1 HHF1, HHF2 HOT1 ISW1 ISW2 KAP114 MAF1 MOT1 NAP1 NIP1 NPL6 POL2 PRT1 PUF6 RET1 RPA12 RPA135 RPA190 RPA43 RPA49 RPB10 RPB5 RPB8 RPC11 RPC17 RPC19 RPC25 RPC31 RPC34 RPC37 RPC40 RPC53 RPC82 RPG1 RPO26 RPO31 RSC8 RVB2 SPT16 SRO7 SSA4 STH1 TIF35 TOP1 UTP22 VPS1 YTA7
    View Details Ho Y, et al. (2002) ACC1 ACH1 ADH2 ADR1 AI1 AIM13 FUN12 GCD11 GFA1 GND1 GUS1 HHF1, HHF2 HHO1 HIR2 HTA1 HTB1 IDH2 IMD2 IMD3 IMD4 ISA2 KAP114 KRI1 MAG1 MDH1 MET18 MPH1 MSH2 NAP1 NGL2 NOP12 NOP4 NOP7 PYC1 PYC2 RET1 RPA12 RPA135 RPA190 RPA49 RPB5 RPC19 RPC25 RPC34 RPC40 RPC82 RPN3 RPO26 RPO31 RVS167 SEC27 SPT16 SXM1 TBS1 TFP1 TIF4631 TIF4632 TSA2 UTP13 UTP22 YFL042C YHR112C YPR015C
    View Details Qiu et al. (2008) RET1 RPA12 RPA190 RPA34 RPA43 RPB10 RPB2 RPB3 RPB5 RPB7 RPB8 RPB9 RPC10 RPC11 RPC17 RPC19 RPC25 RPC31 RPC34 RPC37 RPC40 RPC53 RPC82 RPO21 RPO26 RPO31

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen NPA3 RET1 2 Unpublished Fields Lab Data
    View Screen MET30 RET1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RET1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..202]
    [369..526]
    [573..682]    		 PSI-BLAST 11000.0 RBP2
    2 View Details [203..368]
    [527..572]
    [683..1060]    		 PSI-BLAST 11000.0 RBP2
    3 View Details [1061..1149] PSI-BLAST 11000.0 RBP2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-directed RNA polymerase activity
    		•  10.2021663255698 bayes_pls_golite062009
  • RNA polymerase activity
    		•  10.2021663255698 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  7.6240729546188 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  6.31198922553685 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  5.44374972993429 bayes_pls_golite062009
  • transferase activity
    		•  4.83218811360621 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.34884279395902 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.33174616086951 bayes_pls_golite062009
  • DNA binding
    		•  2.27079409864244 bayes_pls_golite062009
  • binding
    		•  1.73416306650822 bayes_pls_golite062009
  • RNA polymerase II transcription mediator activity
    		•  1.53259746846673 bayes_pls_golite062009
  • catalytic activity
    		•  1.36406839864424 bayes_pls_golite062009
  • RNA binding
    		•  1.12618950637766 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.847783043631028 bayes_pls_golite062009
  • protein binding
    		•  0.45174975126993 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle