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Protein Overview: PRE10

General Information:
Name(s) found: PRE10 / YOR362C [SGD]
Description(s) found:
Found 35 descriptions.
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  • Alpha 7 subunit of the 20S proteasome [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 288 amino acids

    Gene Ontology:
    Cellular Component: proteasome core complex, alpha-subunit complex [IPILink to PubMed article]
    Biological Process: ubiquitin-dependent protein catabolic process [TASLink to PubMed articleLink to PubMed article]
    Molecular Function: endopeptidase activity [TASLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSIGTGYDL SNSVFSPDGR NFQVEYAVKA VENGTTSIGI KCNDGVVFAV EKLITSKLLV  60
   61 PQKNVKIQVV DRHIGCVYSG LIPDGRHLVN RGREEAASFK KLYKTPIPIP AFADRLGQYV 120
  121 QAHTLYNSVR PFGVSTIFGG VDKNGAHLYM LEPSGSYWGY KGAATGKGRQ SAKAELEKLV 180
  181 DHHPEGLSAR EAVKQAAKII YLAHEDNKEK DFELEISWCS LSETNGLHKF VKGDLLQEAI 240
  241 DFAQKEINGD DDEDEDDSDN VMSSDDENAP VATNANATTD QEGDIHLE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BLM10 GNA1 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 SCL1 URH1 YCR076C
    View Details (MIPS) Mewes HW, et al. (2004) PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 SCL1 UMP1
    View Details Krogan NJ, et al. (2006) ACK1 CIN8 DCG1 GNA1 MCM6 MLP1 PMD1 PMT4 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RFT1 SCL1 SGA1 SNQ2 TOS8 UMP1 YCR076C YDR179W-A YJL132W YKR070W YLR211C YLR290C
    View Details Gavin AC, et al. (2006) PRE10 PRE2 PRE3 PRE6 PRE8 PUP3 SCL1
    View Details Gavin AC, et al. (2002) BLM10 CDC55 CDC6 CIN1 DAM1 DBP9 ECM29 ERG13 EST3 GFA1 GUS1 HHF1, HHF2 HOS2 HOS4 IML1 INO4 KAP95 KEL1 LTE1 LYS12 MDS3 MLH2 MYO5 NUD1 PDA1 PDB1 PFK1 PGK1 PPH21 PPH22 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PSE1 PUP1 PUP2 PUP3 RGR1 RPN10 RPN11 RPN12 RPN13 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRD2 RRP12 RTS1 RTS3 SCL1 SET3 SIF2 SLX9 SNT1 SPA2 SRP1 TDH2 TDH3 TEF4 TPD3 UBP6 ULP1 YBL104C YFL006W YMR310C YOR1 YRA1 ZDS1 ZDS2
    View Details Ho Y, et al. (2002) ADD66 ARG4 AYR1 COR1 CPR6 DED1 ERG27 GPT2 GYP5 IDH1 ILV5 LIA1 LYS12 MAE1 MET18 OM45 PBA1 PCT1 PDA1 PET10 PET9 PHO84 PIL1 PRE1 PRE10 PRE2 PRE3 PRE5 PRE6 PRE7 PRE8 PRE9 PRO3 PUP2 PUP3 RET2 RNR2 RTN2 RVS161 RVS167 SCL1 SEC18 SEC21 SEC26 SEC27 SEC28 TIF34 TIF35 TPA1 URA7 YHR033W YLR243W YNL181W
    View Details Qiu et al. (2008) BLM10 NAS6 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RPN1 RPN10 RPN11 RPN12 RPN13 RPN2 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 SCL1 UMP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PRE10 ULI1 2 Unpublished Fields Lab Data
    View Screen PRE10 SCL1 2 Unpublished Fields Lab Data
    View Screen PRE10 YGL165C 2 Unpublished Fields Lab Data
    View Screen PRE10 PUP2 2 Unpublished Fields Lab Data
    View Screen PRE10 YLR076C 2 Unpublished Fields Lab Data
    View Screen PRE10 RIM13 2 Unpublished Fields Lab Data
    View Screen PRE10 PRE5 2 Unpublished Fields Lab Data
    View Screen PRE10 SUI1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PRE10 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..288] PSI-BLAST 1703.39794 CRYSTAL STRUCTURE OF THE 20S PROTEASOME FROM YEAST IN COMPLEX WITH THE PROTEASOME ACTIVATOR PA26 FROM TRYPANOSOME BRUCEI AT 3.2 ANGSTROMS RESOLUTION

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • endopeptidase activity
    		•  6.91642761177919 bayes_pls_golite062009
  • peptidase activity
    		•  6.84511694091156 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  6.5973571808298 bayes_pls_golite062009
  • hydrolase activity
    		•  4.47652590304822 bayes_pls_golite062009
  • threonine-type endopeptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • threonine-type peptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • catalytic activity
    		•  1.19663085909195 bayes_pls_golite062009
  • binding
    		•  0.982918122186083 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.448212653390607 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle