YRC Public Data Repository - Protein Structure Prediction

Protein:	PRE10
Organism:	Saccharomyces cerevisiae
Length:	288 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRE10.

Description	E-value	Query Range	Subject Range
PRE10 - Alpha 7 subunit of the 20S proteasome gi\|190407655 - gi\|190407655\|gb\|EDV10922.1\| proteasome component YC1 [Saccharomyces cerevisiae RM11-1a] gi\|151945439 - gi\|151945439\|gb\|EDN63682.1\| proteasome component YC1 (protease yscE subunit 1) [Saccharomyces cerevi... PSA7_YEAST - Probable proteasome subunit alpha type-7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...	1.0E-93	[1..288]	[1..288]
gi\|286250 - gi\|286250\|dbj\|BAA01587.1\| proteasome subunit R-IOTA [Rattus sp.] gi\|67969980 - gi\|67969980\|dbj\|BAE01337.1\| unnamed protein product [Macaca fascicularis] PSMA6 - proteasome (prosome, macropain) subunit, alpha type, 6 PSA6_BOVIN - Proteasome subunit alpha type-6 OS=Bos taurus GN=PSMA6 PE=1 SV=1 gi\|55640605, gi\|... - gi\|55640605\|ref\|XP_509906.1\| PREDICTED: proteasome alpha 6 subunit isoform 6 [Pan troglodytes], gi\|1... gi\|109083327, gi... - gi\|109083327\|ref\|XP_001086524.1\| PREDICTED: similar to Proteasome subunit alpha type 6 (Proteasome i... gi\|149692835 - gi\|149692835\|ref\|XP_001491320.1\| PREDICTED: similar to proteasome alpha 6 subunit [Equus caballus] ENSOCUP000000134... - pep:novel chromosome:oryCun2:17:55028440:55047757:1 gene:ENSOCUG00000015635 transcript:ENSOCUT000000... PSA6_RAT - Proteasome subunit alpha type-6 OS=Rattus norvegicus GN=Psma6 PE=1 SV=1 gi\|123983062 - gi\|123983062\|gb\|ABM83272.1\| proteasome (prosome, macropain) subunit, alpha type, 6 [synthetic constr... gi\|222154129 - gi\|222154129\|gb\|ACM47241.1\| proteasome subunit alpha type 6 [Capra hircus] tr\|M3WV20\|M3WV20... - Proteasome subunit alpha type OS=Felis catus GN=PSMA6 PE=3 SV=1	3.0E-87	[1..246]	[1..246]
PSA6_MOUSE - Proteasome subunit alpha type-6 OS=Mus musculus GN=Psma6 PE=1 SV=1	1.0E-86	[1..246]	[1..246]
gi\|33416349, gi\|... - gi\|33416349\|gb\|AAH55520.1\| Psma6a protein [Danio rerio], gi\|182891590\|gb\|AAI64827.1\| Psma6a protein ...	4.0E-85	[1..246]	[1..246]
PSA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=psmA PE=3 SV=1 PSMA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi GN=psmA PE=3 SV=1	3.0E-83	[6..239]	[8..234]
PSA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC ... PSMA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii GN=psmA PE=3 SV=1	2.0E-82	[6..239]	[8..234]
PSA4A_ARATH - Proteasome subunit alpha type-4-A OS=Arabidopsis thaliana GN=PAC1 PE=1 SV=1	4.0E-82	[4..250]	[1..248]
PSA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) GN=p... PSMA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus GN=psmA PE=3 SV=1	1.0E-81	[6..239]	[8..234]
PSA_THEK1 - Proteasome subunit alpha OS=Thermococcus sp. (strain JCM 11816 / KS-1) GN=psmA PE=3 SV=1 PSA_THEK1, PSMA_... - Proteasome subunit alpha OS=Thermococcus sp. (strain KS-1) GN=psmA PE=3 SV=1, Proteasome subunit alp... gi\|11265988 - pir\|\|T43887 proteasome alpha chain [imported] - Thermococcus sp	2.0E-81	[6..242]	[8..237]

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Predicted Domain #1

Region A:
Residues: [1-288]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSIGTGYDL SNSVFSPDGR NFQVEYAVKA VENGTTSIGI KCNDGVVFAV EKLITSKLLV  60
   61 PQKNVKIQVV DRHIGCVYSG LIPDGRHLVN RGREEAASFK KLYKTPIPIP AFADRLGQYV 120
  121 QAHTLYNSVR PFGVSTIFGG VDKNGAHLYM LEPSGSYWGY KGAATGKGRQ SAKAELEKLV 180
  181 DHHPEGLSAR EAVKQAAKII YLAHEDNKEK DFELEISWCS LSETNGLHKF VKGDLLQEAI 240
  241 DFAQKEINGD DDEDEDDSDN VMSSDDENAP VATNANATTD QEGDIHLE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1703.39794
Match:	1fntG_
Description:	CRYSTAL STRUCTURE OF THE 20S PROTEASOME FROM YEAST IN COMPLEX WITH THE PROTEASOME ACTIVATOR PA26 FROM TRYPANOSOME BRUCEI AT 3.2 ANGSTROMS RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
endopeptidase activity	6.91642761177919	bayes_pls_golite062009
peptidase activity	6.84511694091156	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	6.5973571808298	bayes_pls_golite062009
hydrolase activity	4.47652590304822	bayes_pls_golite062009
threonine-type endopeptidase activity	2.98214579292788	bayes_pls_golite062009
threonine-type peptidase activity	2.98214579292788	bayes_pls_golite062009
catalytic activity	1.19663085909195	bayes_pls_golite062009
binding	0.982918122186083	bayes_pls_golite062009
nucleic acid binding	0.448212653390607	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: