Protein Overview: STM1

General Information:
Name(s) found:	STM1 / YLR150W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|730057\|sp\|P39015.3\|STM1_YEAST RecName: Full=Suppressor protein STM1; AltName: Full=GU4 nucleic-binding protein 2; Short=G4p2 protein; AltName: Full=Triplex-binding protein 1; AltName: Full=3BP1; AltName: Full=Ribosomal subunits association factor; Shor [NCBI NR] gi\|725457\|dbj\|BAA06907.1\| Stm1p [Saccharomyces cerevisiae] [NCBI NR] gi\|6323179\|ref\|NP_013251.1\| Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations; Stm1p [ [NCBI NR] pir\|\|S48511 MPT4 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|45269780\|gb\|AAS56270.1\| YLR150W [Saccharomyces cerevisiae] [NCBI NR] gi\|450488\|dbj\|BAA05171.1\| suppressor protein [Saccharomyces cerevisiae] [NCBI NR] gi\|1583128\|prf\|\|2120242A STM1 gene [NCBI NR] gi\|1360580\|emb\|CAA97722.1\| MPT4 [Saccharomyces cerevisiae] [NCBI NR] gi\|1262310\|gb\|AAB82384.1\| Stm1p: G4 quadruplex nucleic acid binding protein [Saccharomyces cerevisiae] [NCBI NR] Suppressor protein STM1 OS=Saccharomyces cerevisiae GN=STM1 PE=1 SV=3 [Swiss-Prot] (P39015) Suppressor protein MPT4 (STM1 protein) (GU4 nucleic-binding protein 2) (G4p2 protein) [Swiss-Prot] STM1 Specific affinity for guanine-rich quadruplex nucleic acids [mips] Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure [SGD] STM1, Chr XII from 440468-441289 [yeast_orfs2] Chr XII from 440468-441289 [yeastorf3.fasta] STM1 SGDID:S0004140, Chr XII from 440468-441289, Verified ORF [yeastflysequest.fasta] Protein that binds quadruplex nucleic acids; multicopy suppressor of tom1 and pop2 mutations; acts with Cdc13p to maintain telomere structure [Saccharomyces cerevisiae]gi\|1360580\|emb\|CAA97722.1\| MPT4 [Saccharomyces cerevisiae]gi\|626746\|pir\|\|S48511 MPT4 [nrdb_11152004_Chlamydomonas] STM1 SGDID:S000004140, Chr XII from 440468-441289, Verified ORF, "Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppress [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] STM1 SGDID:S000004140, Chr XII from 440468-441289, Verified ORF, "Protein required for optimal translation under nutrient stress; involved in TOR signaling pathway; binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain te [yeast-200209-contam.fasta] Stm1p: G4 quadruplex nucleic acid binding protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] STM1 gene [nr-271106-contam.fasta] suppressor protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Stm1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations; Stm1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YLR150W [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Suppressor protein STM1 (GU4 nucleic-binding protein 2) (G4p2 protein) (Triplex-binding protein 1) (3BP1) (Ribosomal subunits association factor) (AF) (POP2 multicopy suppressor protein 4) (TOM1 suppressor protein 1) [nr-271106-contam.fasta] MPT4 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] STM1 SGDID:S000004140, Chr XII from 440468-441289, Verified ORF, "Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta] STM1 SGDID:S000004140, Chr XII from 440468-441289, Verified ORF, "Protein required for optimal translation under nutrient stress; involved in TOR signaling pathway; binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure" [yeast-bovrabprots.fasta] STM1 SGDID:S000004140, Chr XII from 440468-441289, Verified ORF, "Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations" [yeast-contam_custom.fasta] [chemostatdb.fasta] STM1 SGDID:S000004140, Chr XII from 440468-441289, Verified ORF, "Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure" [SGDyeast.20101221.fasta] Suppressor protein STM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=STM1 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] STM1 SGDID:S000004140, Chr XII from 440467-441288, Genome Release 64-1-1, Verified ORF, "Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure" [yeast-030211-contam.fasta] STM1 SGDID:S000004140, Chr XII from 440467-441288, Genome Release 64-2-1, Verified ORF, "Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery" [20141208_orf_trans.fasta] YLR150W SGDID:S000004140, Chr XII from 440467-441288, Genome Release 64-1-1, Verified ORF, "Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	273 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA] nuclear telomere cap complex [IGI]
Biological Process:	anti-apoptosis [IDA] telomere maintenance [IMP]
Molecular Function:	DNA binding [IDA] telomeric DNA binding [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNPFDLLGN DVEDADVVVL PPKEIVKSNT SSKKADVPPP SADPSKARKN RPRPSGNEGA  60
   61 IRDKTAGRRN NRSKDVTDSA TTKKSNTRRA TDRHSRTGKT DTKKKVNQGW GDDKKELSAE 120
  121 KEAQADAAAE IAEDAAEAED AGKPKTAQLS LQDYLNQQAN NQFNKVPEAK KVELDAERIE 180
  181 TAEKEAYVPA TKVKNVKSKQ LKTKEYLEFD ATFVESNTRK NFGDRNNNSR NNFNNRRGGR 240
  241 GARKGNNTAN ATNSANTVQK NRNIDVSNLP SLA

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CBF5 DBP2 FUN12 IMD3 IMD4 KEM1 KRE33 PRP43 PWP1 RBG1 RPA49 RPL10 RPL15A RPL20B RPL2A, RPL2B RPL4B RPL5 RPP0 RPS11A, RPS11B RPS13 RPS1B RPS3 RPS4B, RPS4A RPS6A, RPS6B RPS7A RPS8B, RPS8A STM1 UTP22 YGR054W
View Details	Krogan NJ, et al. (2006)		ASE1 RPS25B STM1 VTS1 YPL150W
View Details	Gavin AC, et al. (2006)		STM1 VHR1
View Details	Gavin AC, et al. (2002)		ASC1 BSP1 BZZ1 CBF5 CDC33 CHC1 CKA1 CKA2 CKB1 DBP2 ECM25 END3 HEK2 HHF1, HHF2 INP52 LAS17 LHP1 LSB3 MIS1 MRP7 MRPS28 NAB6 NUP120 NUP145 NUP84 NUP85 POL2 PUS7 RAD51 RBG1 ROM2 RPP2B SBP1 SEC13 SEC16 SEC23 SEC31 SEH1 SLA1 SLA2 SNP1 SRO9 STM1 STO1 SUI3 SYP1 TFP1 TIF1, TIF2 TIF4631 TIF4632 UTP20 VRP1 YMR310C YPT7 YSC84
View Details	Qiu et al. (2008)		PCC1 RAP1 RIF1 RIF2 RKI1 RPL10 RPL13A RPL16A RPL17B RPL18A, RPL18B RPL20B RPL21B RPL22A RPL24A RPL24B RPL26A RPL3 RPL31A RPL34A RPL34B RPL35A, RPL35B RPL37A RPL38 RPL40B, RPL40A RPL42B, RPL42A RPL43B, RPL43A RPL4A RPL4B RPL5 RPL6A RPL6B RPL7A RPL8A RPL8B RPL9A RPP1A RPP1B RPP2B RPS11A, RPS11B RPS18B, RPS18A RPS1A RPS21B RPS23B, RPS23A RPS26B RPS28B RPS29A RPS4B, RPS4A RPS7B RPS9A STM1 SUB2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	TOR2	No Comments	Reinke A, et al. (2004)
View Run	DAD1	Dam1-765 complex purified from yeast with Dad1-TAP	Shimogawa MM, et al. (2006)
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	ASF1	sample 3928 - Asf1-S-TEV-ZZ (in hir3delta mutant)	Green EM, et al (2005)
View Run	BOI1	Sample boi 1 with ha tag from october 2005	McCusker D, et al (2007)
View Run	BOI1	Sample boi1 with gst from october 2005	McCusker D, et al (2007)
View Run	BOI1	Sample bob1 (2nd set) from october 2005	McCusker D, et al (2007)
View Run	MLP2	#19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2	Keck JM, et al. (2011)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#10 Mitotic Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#02 Alpha Factor Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)
View Run	MLP2	#01 Alpha factor Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#28 Asynchronous Prep5-TiO2 Phosphopeptide Enrichment	Keck JM, et al. (2011)
View Run	MLP2	#19b Asynchronous Prep1-new search criteria	Keck JM, et al. (2011)
View Run	MLP2	#07 Alpha Factor Prep3-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#09 Alpha Factor Prep4-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#19a Asynchronous Prep1-new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	STM1	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..273]	deduced	N/A	No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: STM1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: