Protein Overview: RIF2

General Information:
Name(s) found:	RIF2 / YLR453C [SGD]
Description(s) found: Found 24 descriptions. SHOW ALL	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation [SGD]
Organism:	Saccharomyces cerevisiae
Length:	395 amino acids
Gene Ontology:
Cellular Component:	nuclear telomere cap complex [IDA]
Biological Process:	telomere maintenance [IMP] telomere maintenance via telomerase [IMP]
Molecular Function:	telomeric DNA binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEHVDSDFAP IRRSKKVVDS DKIVKAISDD LEQKNFTVLR KLNLVPIKKS VSSPKVCKPS  60
   61 PVKERVDHVF YQKFKSMALQ ELGTNYLSIS YVPSLSKFLS KNLRSMKNCI VFFDKVEHIH 120
  121 QYAGIDRAVS ETLSLVDINV VIIEMNDYLM KEGIQSSKSK ECIESMGQAS YSGQLDFEAS 180
  181 EKPSNHTSDL MMMVMRKINN DESIDHIVYF KFEQLDKLST STIIEPSKLT EFINVLSVLE 240
  241 KSNNIAFKVL IYSNNVSISS LLSTSLKKKL NTKYTVFEMP ILTCAQEQEY LKKMIKFTFD 300
  301 SGSKLLQSYN SLVTCQLNNK ESNLAIFFEF LKVFPHPFTY LFNAYTEIIV QSRTFDELLD 360
  361 KIRNRLTIKN YPHSAYNFKK NQRLPLKLTR KVHDR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		CDC13 RIF1 RIF2 STM1 TEL2

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	NSE3	RIF2	2	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	RIF2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..395]	deduced	N/A	No confident structure predictions are available.
2	View Details	[184..395]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2