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Protein Overview: SBP1

General Information:
Name(s) found: SBP1 / YHL034C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 294 amino acids

    Gene Ontology:
    Cellular Component: nuclear outer membrane [IMPLink to PubMed article]
    nucleolus [IDALink to PubMed articleLink to PubMed article]
    Biological Process: negative regulation of translation in response to stress [IMP]
    response to stress [IEA]
    Molecular Function: snoRNA binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAEIEEATN AVNNLSINDS EQQPRAPTHK TVIDPEDTIF IGNVAHECTE DDLKQLFVEE  60
   61 FGDEVSVEIP IKEHTDGHIP ASKHALVKFP TKIDFDNIKE NYDTKVVKDR EIHIKRARTP 120
  121 GQMQRGGFRG RGGFRGRGGF RGGFRGGYRG GFRGRGNFRG RGGARGGFNG QKREKIPLDQ 180
  181 MERSKDTLYI NNVPFKATKE EVAEFFGTDA DSISLPMRKM RDQHTGRIFT SDSANRGMAF 240
  241 VTFSGENVDI EAKAEEFKGK VFGDRELTVD VAVIRPENDE EEIEQETGSE EKQE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRX1 CBF5 CDC33 GBP2 KEM1 RBG1 RPL11B RPL16A RPL4A RPL5 RPL6A RPS16B, RPS16A RPS17B RPS22A RPS5 RPS8B, RPS8A RPS9B SBP1 SRO9 STO1 YGR054W
    View Details (MIPS) Mewes HW, et al. (2004) DRS1 GAR1 IFH1 NOP1 NPL3 NSR1 POP1 POP2 RAT1 RNT1 RRP3 SBP1 SNM1 SRD1 UTP10 UTP11 UTP13 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9 YME2
    View Details Krogan NJ, et al. (2006) BUD22 CIC1 DBP6 EFG1 FRE3 GIS2 HAS1 MAK21 NIP7 NOB1 NOC2 NOC3 NOP1 NOP2 NOP8 PUS7 RRP5 RSA3 SBP1 SFA1 SSQ1 YGR272C YMR034C YRF1-8, YRF1-5, ...
    View Details Gavin AC, et al. (2006) CDC33 SBP1 TIF4631 TIF4632
    View Details Gavin AC, et al. (2002) ASC1 CAM1 CBF5 CDC33 DBP2 EFB1 FAP1 GFA1 GUS1 HEK2 HHF1, HHF2 ILV1 KAP123 LHP1 MGA2 MIS1 MRP7 NAB6 NEW1 OLA1 POL2 PUS7 RBG1 ROM2 SBP1 SEC27 SNP1 SRO9 STM1 STO1 SUI3 TEF1, TEF2 TEF4 TIF1, TIF2 TIF4631 TIF4632 UTP20 YMR310C
    View Details Qiu et al. (2008) DIP2 ENP1 GAR1 MRD1 NPL3 RRP9 SBP1 SOF1 UTP11 UTP13 UTP15 UTP5 UTP6 UTP7 UTP9 YME2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SBP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..150] PSI-BLAST 25.0 Poly(A)-binding protein
    2 View Details [151..294] PSI-BLAST 25.0 Poly(A)-binding protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • mRNA binding
    		•  4.52007814408702 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51665560478175 bayes_pls_golite062009
  • RNA binding
    		•  4.50438526063124 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
  • structural molecule activity
    		•  2.78501986457503 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.7776932219095 bayes_pls_golite062009
  • DNA binding
    		•  1.65208390030564 bayes_pls_golite062009
    		• 1.49431666307335 bayes_pls_golite062009
  • mRNA 5'-UTR binding
    		•  1.30855696645617 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.998305828880243 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.950575788044751 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.90573796517364 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.87797657439186 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.824614388276642 bayes_pls_golite062009
  • transcription factor activity
    		•  0.795084003256395 bayes_pls_golite062009
  • translation repressor activity, nucleic acid binding
    		•  0.461000905454505 bayes_pls_golite062009
  • hydrolase activity
    		•  0.389390547875764 bayes_pls_golite062009
  • translation regulator activity
    		•  0.38120065819101 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  0.32812362201346 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.304235325881492 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.128616879457381 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle