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Protein Overview: PWP2

General Information:
Name(s) found: PWP2 / YCR057C [SGD]
Description(s) found:
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  • gi|730431|sp|P25635.2|PWP2_YEAST RecName: Full=Periodic tryptophan protein 2; AltName: Full=U3 small nucleolar RNA-associated protein 1; Short=U3 snoRNA-associated protein 1; AltName: Full=U three protein 1 [NCBI NR]
  • gi|6319903|ref|NP_009984.1| Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenes [NCBI NR]
  • pir||S44226 periodic tryptophan protein PWP2 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|475231|emb|CAA55558.1| periodic tryptophan protein 2 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1907198|emb|CAA42286.1| periodic tryptophan protein [Saccharomyces cerevisiae] [NCBI NR]
  • Periodic tryptophan protein 2 OS=Saccharomyces cerevisiae GN=PWP2 PE=1 SV=2 [Swiss-Prot]
  • PWP2 Periodic tryptophan protein [mips]
  • Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis [SGD]
  • PWP2, Chr III from 220449-223220, reverse complement [yeast_orfs2]
  • Chr III from 220449-223220, reverse complement [yeastorf3.fasta]
  • Chr III from 223220-220449, reverse complement [yeastorf5.fasta]
  • (P25635) Periodic tryptophan protein 2 [4932.FASTACCERV.txt]
  • PWP2 SGDID:S0000653, Chr III from 223223-220452, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Pwp2p [Saccharomyces cerevisiae]gi|1907198|emb|CAA42286.1| periodic tryptophan protein [Saccharomyces cerevisiae]gi|475231|emb|CAA55558.1| periodic tryptophan protein 2 [Saccharomyces cerevisiae]gi|730431|sp|P25635|PWP2_YEAST Periodic tryptophan protei [nrdb_11152004_Chlamydomonas]
  • PWP2 SGDID:S000000653, Chr III from 223223-220452, reverse complement, Verified ORF, "Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 d [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • PWP2 SGDID:S000000653, Chr III from 223224-220453, reverse complement, Verified ORF, "Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 d [yeast-contam.fasta]
  • periodic tryptophan protein 2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis; Pwp2p [Saccharomyces cer [nr-271106-contam.fasta]
  • periodic tryptophan protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Periodic tryptophan protein 2 (U3 small nucleolar RNA-associated protein 1) (U3 snoRNA-associated protein 1) [nr-271106-contam.fasta]
  • PWP2 SGDID:S000000653, Chr III from 223224-220453, reverse complement, Verified ORF, "Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Periodic tryptophan protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PWP2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PWP2 SGDID:S000000653, Chr III from 223228-220457, Genome Release 64-1-1, reverse complement, Verified ORF, "Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis" [yeast-030211-contam.fasta]
  • PWP2 SGDID:S000000653, Chr III from 223228-220457, Genome Release 64-2-1, reverse complement, Verified ORF, "Conserved 90S pre-ribosomal component; essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis" [20141208_orf_trans.fasta]
  • YCR057C SGDID:S000000653, Chr III from 223228-220457, Genome Release 64-1-1, reverse complement, Verified ORF, "Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 923 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    nuclear outer membrane [IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed article]
    90S preribosome [IDALink to PubMed article]
    small nucleolar ribonucleoprotein complex [IPILink to PubMed article]
    Biological Process: maturation of SSU-rRNA [IMPLink to PubMed article][IPILink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: snoRNA binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSDFKFSNL LGTVYRQGNI TFSDDGKQLL SPVGNRVSVF DLINNKSFTF EYEHRKNIAA  60
   61 IDLNKQGTLL ISIDEDGRAI LVNFKARNVL HHFNFKEKCS AVKFSPDGRL FALASGRFLQ 120
  121 IWKTPDVNKD RQFAPFVRHR VHAGHFQDIT SLTWSQDSRF ILTTSKDLSA KIWSVDSEEK 180
  181 NLAATTFNGH RDYVMGAFFS HDQEKIYTVS KDGAVFVWEF TKRPSDDDDN ESEDDDKQEE 240
  241 VDISKYSWRI TKKHFFYANQ AKVKCVTFHP ATRLLAVGFT SGEFRLYDLP DFTLIQQLSM 300
  301 GQNPVNTVSV NQTGEWLAFG SSKLGQLLVY EWQSESYILK QQGHFDSTNS LAYSPDGSRV 360
  361 VTASEDGKIK VWDITSGFCL ATFEEHTSSV TAVQFAKRGQ VMFSSSLDGT VRAWDLIRYR 420
  421 NFRTFTGTER IQFNCLAVDP SGEVVCAGSL DNFDIHVWSV QTGQLLDALS GHEGPVSCLS 480
  481 FSQENSVLAS ASWDKTIRIW SIFGRSQQVE PIEVYSDVLA LSMRPDGKEV AVSTLKGQIS 540
  541 IFNIEDAKQV GNIDCRKDII SGRFNQDRFT AKNSERSKFF TTIHYSFDGM AIVAGGNNNS 600
  601 ICLYDVPNEV LLKRFIVSRN MALNGTLEFL NSKKMTEAGS LDLIDDAGEN SDLEDRIDNS 660
  661 LPGSQRGGDL STRKMRPEVR VTSVQFSPTA NAFAAASTEG LLIYSTNDTI LFDPFDLDVD 720
  721 VTPHSTVEAL REKQFLNALV MAFRLNEEYL INKVYEAIPI KEIPLVASNI PAIYLPRILK 780
  781 FIGDFAIESQ HIEFNLIWIK ALLSASGGYI NEHKYLFSTA MRSIQRFIVR VAKEVVNTTT 840
  841 DNKYTYRFLV STDGSMEDGA ADDDEVLLKD DADEDNEENE ENDVVMESDD EEGWIGFNGK 900
  901 DNKLPLSNEN DSSDEEENEK ELP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BMS1 DIM1 DIP2 ECM16 EMG1 ENP2 IMP3 KRE33 MPP10 NAN1 NOC4 NOP1 NOP14 NOP56 PNO1 PWP2 ROK1 RPS13 RRP9 SOF1 UTP10 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8
    View Details Krogan NJ, et al. (2006) DIP2 HSV2 PWP2 UTP13 UTP18 UTP21 UTP6 YJL147C
    View Details Gavin AC, et al. (2006) CMS1 DIP2 MRD1 NAN1 NOP58 PNO1 PWP2 ROK1 RRP9 UTP10 UTP13 UTP15 UTP18 UTP21 UTP22 UTP4 UTP6 UTP7 UTP8 UTP9
    View Details Gavin AC, et al. (2002) ADE4 ASC1 BFR2 BMS1 BRX1 BUD21 CBF5 CFT2 CKA1 CKA2 CKB1 CKB2 CMS1 DBP8 DIA4 DIM1 DIP2 DIS3 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HSL1 HTA2 IMP3 IMP4 KRE33 KRR1 LCP5 LTV1 MPP10 MRD1 MVD1 NAN1 NOB1 NOC2 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 PAP1 PFS2 PNO1 PRE6 PRE9 PRP43 PTA1 PTI1 PWP2 RCL1 REF2 RML2 RNA14 ROK1 RPP2B RRP12 RRP7 RRP9 RTG2 SAM1 SCL1 SEC21 SLX9 SOF1 SRO9 TIF1, TIF2 TSR1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YOR059C YSH1
    View Details Ho Y, et al. (2002) CKA1 CKA2 CKB1 CKB2 DIP2 ESL2 KRE33 LCP5 NAN1 NOP1 NOP56 PNO1 PRP40 PTC5 PWP2 RRP5 TFP1 UTP10 UTP11 UTP13 UTP14 UTP18 UTP21 UTP22 UTP30 UTP6 YGR210C
    View Details Qiu et al. (2008) BUD21 CIC1 DBP6 DBP7 DHR2 ENP1 ERB1 GAR1 HCA4 IMP3 IMP4 KRE33 LCP5 LTV1 MRD1 NAN1 NHP2 NOB1 NOC3 NOC4 NOP12 NOP14 NSR1 NUG1 PRP43 PWP2 RRP5 RRP9 RSA3 SAS10 SOF1 UTP10 UTP11 UTP13 UTP14 UTP15 UTP21 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen BUR2 PWP2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PWP2 Huh WK, et al. (2003)
    View Data PWP2 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..84] MSA 1.441995 View MSA. No confident structure predictions are available.
    2 View Details [85..416] PSI-BLAST 131.274545 Groucho/tle1, C-terminal domain
    3 View Details [417..501] PSI-BLAST 252.69897 beta1-subunit of the signal-transducing G protein heterotrimer
    4 View Details [502..676] PSI-BLAST 202.9897 Tup1, C-terminal domain
    5 View Details [677..743] deduced N/A No confident structure predictions are available.
    6 View Details [744..923] MSA 2.054975 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle