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Complex Overview

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC45
  • replication fork
  • pre-replicative complex
  • DNA replication initiation
  • DNA strand elongation involved in DNA replication
  • pre-replicative complex assembly
  • DNA binding
  • ERG26
  • endoplasmic reticulum membrane
  • endoplasmic reticulum
  • ergosterol biosynthetic process
  • C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
  • GLT1
  • mitochondrion
  • glutamate synthase complex
  • glutamate biosynthetic process
  • glutamate synthase (NADH) activity
  • HAT1
  • nucleus
  • cytoplasm
  • histone acetyltransferase complex
  • histone acetylation
  • chromatin silencing at telomere
  • histone binding
  • HSP42
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • response to stress
  • unfolded protein binding
  • LYS12
  • mitochondrion
  • lysine biosynthetic process
  • homoisocitrate dehydrogenase activity
  • MCM2
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
  • chromatin binding
  • ATP-dependent DNA helicase activity
  • MCM5
  • replication fork
  • pre-replicative complex
  • cytoplasm
  • MCM complex
  • DNA replication initiation
  • establishment of chromatin silencing
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
  • chromatin binding
  • ATP-dependent DNA helicase activity
  • MCM6
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
  • DNA replication initiation
  • DNA unwinding involved in replication
  • chromatin binding
  • ATP-dependent DNA helicase activity
  • MCM7
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
  • ATP binding
  • chromatin binding
  • ATP-dependent DNA helicase activity
  • ORC1
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • ATPase activity
  • DNA replication origin binding
  • ORC2
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • DNA replication origin binding
  • ORC3
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • DNA replication origin binding
  • ORC4
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • DNA replication origin binding
  • ORC5
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • ATPase activity
  • DNA replication origin binding
  • ORC6
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • DNA replication origin binding
  • RPD3
  • histone deacetylase complex
  • negative regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at rDNA
  • loss of chromatin silencing involved in replicative cell aging
  • protein amino acid deacetylation
  • chromatin silencing
  • double-strand break repair via nonhomologous end joining
  • chromatin organization
  • histone deacetylation
  • chromatin silencing at silent mating-type cassette
  • positive regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at telomere
  • mitotic recombination
  • transcription coactivator activity
  • histone deacetylase activity
  • transcription corepressor activity
  • RPN9
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • SIN3
  • Sin3 complex
  • histone deacetylase complex
  • negative regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at rDNA
  • telomere maintenance
  • double-strand break repair via nonhomologous end joining
  • histone deacetylation
  • chromatin silencing at silent mating-type cassette
  • positive regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at telomere
  • transcription coactivator activity
  • histone deacetylase activity
  • transcription corepressor activity
  • TFP1
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
  • protein metabolic process
  • vacuolar acidification
  • intron homing
  • proton-transporting ATPase activity, rotational mechanism
  • endodeoxyribonuclease activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    pre-replicative complex 4.7964E-26 20 16 11 6292
    protein-DNA complex 1.9194E-18 20 57 11 6292
    nucleoplasm part 4.0229E-16 20 245 14 6292
    origin recognition complex 4.5084E-16 20 6 6 6292
    nuclear origin of replication recognition complex 4.5084E-16 20 6 6 6292
    nucleoplasm 1.1563E-15 20 264 14 6292
    chromosomal part 5.9782E-13 20 237 12 6292
    nuclear chromosome part 1.8927E-12 20 190 11 6292
    nuclear lumen 2.1532E-12 20 453 14 6292
    chromosome 3.3874E-12 20 274 12 6292
    nuclear chromosome 1.4043E-11 20 228 11 6292
    protein complex 1.3875E-10 20 1137 17 6292
    organelle lumen 3.6482E-10 20 660 14 6292
    intracellular organelle lumen 3.6482E-10 20 660 14 6292
    membrane-enclosed lumen 8.0565E-10 20 700 14 6292
    MCM complex 2.5833E-9 20 7 4 6292
    macromolecular complex 2.9554E-9 20 1635 18 6292
    nuclear part 3.254E-7 20 1103 14 6292
    non-membrane-bounded organelle 6.0481E-7 20 959 13 6292
    intracellular non-membrane-bounded organelle 6.0481E-7 20 959 13 6292
    intracellular organelle part 8.0178E-5 20 2282 16 6292
    organelle part 8.0178E-5 20 2282 16 6292
    nucleus 6.3231E-4 20 2041 14 6292
    intracellular organelle 1.9366E-3 20 4070 19 6292
    organelle 1.9449E-3 20 4071 19 6292
    histone deacetylase complex 2.3335E-3 20 23 2 6292
    glutamate synthase complex 3.1786E-3 20 1 1 6292
    membrane-bounded organelle 3.5096E-3 20 3771 18 6292
    intracellular membrane-bounded organelle 3.5096E-3 20 3771 18 6292
    replication fork 7.6592E-3 20 42 2 6292
    intracellular part 7.7919E-3 20 4938 20 6292
    intracellular 9.0491E-3 20 4975 20 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    pre-replicative complex assembly 1.9772E-24 20 13 10 6292
    DNA replication initiation 2.0781E-21 20 33 11 6292
    protein-DNA complex assembly 4.2324E-18 20 39 10 6292
    DNA-dependent DNA replication 1.4092E-16 20 82 11 6292
    DNA replication 1.4686E-14 20 123 11 6292
    chromatin silencing at silent mating-type cassette 2.7635E-14 20 33 8 6292
    negative regulation of gene expression, epigenetic 1.0542E-13 20 100 10 6292
    gene silencing 1.0542E-13 20 100 10 6292
    regulation of gene expression, epigenetic 1.0542E-13 20 100 10 6292
    chromatin silencing 1.0542E-13 20 100 10 6292
    negative regulation of transcription, DNA-dependent 1.048E-11 20 157 10 6292
    negative regulation of RNA metabolic process 1.1172E-11 20 158 10 6292
    negative regulation of transcription 1.625E-11 20 164 10 6292
    negative regulation of gene expression 1.625E-11 20 164 10 6292
    negative regulation of macromolecule biosynthetic process 3.1154E-11 20 175 10 6292
    negative regulation of nitrogen compound metabolic process 4.1292E-11 20 180 10 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.1292E-11 20 180 10 6292
    cellular macromolecular complex assembly 4.6111E-11 20 182 10 6292
    negative regulation of biosynthetic process 6.7192E-11 20 189 10 6292
    negative regulation of cellular biosynthetic process 6.7192E-11 20 189 10 6292
    DNA metabolic process 7.1242E-11 20 585 14 6292
    negative regulation of macromolecule metabolic process 7.8605E-11 20 192 10 6292
    negative regulation of cellular metabolic process 1.8259E-10 20 209 10 6292
    negative regulation of metabolic process 1.9144E-10 20 210 10 6292
    negative regulation of cellular process 1.0681E-9 20 250 10 6292
    negative regulation of biological process 1.2007E-9 20 253 10 6292
    cellular macromolecular complex subunit organization 1.5106E-9 20 259 10 6292
    macromolecular complex assembly 3.3492E-9 20 281 10 6292
    macromolecular complex subunit organization 3.3871E-8 20 357 10 6292
    regulation of transcription, DNA-dependent 3.4792E-8 20 358 10 6292
    biosynthetic process 3.7533E-8 20 1602 17 6292
    regulation of RNA metabolic process 3.9736E-8 20 363 10 6292
    regulation of transcription 6.8005E-8 20 384 10 6292
    cellular component assembly 6.9712E-8 20 385 10 6292
    DNA unwinding involved in replication 7.2836E-8 20 14 4 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.4224E-7 20 415 10 6292
    regulation of nitrogen compound metabolic process 1.4552E-7 20 416 10 6292
    cellular nitrogen compound metabolic process 1.8635E-7 20 1770 17 6292
    nitrogen compound metabolic process 2.2502E-7 20 1791 17 6292
    regulation of gene expression 2.7503E-7 20 445 10 6292
    regulation of macromolecule biosynthetic process 3.4606E-7 20 456 10 6292
    cellular biosynthetic process 3.4796E-7 20 1567 16 6292
    DNA geometric change 3.4825E-7 20 20 4 6292
    DNA duplex unwinding 3.4825E-7 20 20 4 6292
    regulation of cellular biosynthetic process 4.7829E-7 20 472 10 6292
    regulation of biosynthetic process 4.8786E-7 20 473 10 6292
    regulation of macromolecule metabolic process 6.533E-7 20 488 10 6292
    cellular macromolecule biosynthetic process 8.362E-7 20 1187 14 6292
    macromolecule biosynthetic process 8.5442E-7 20 1189 14 6292
    nucleic acid metabolic process 8.6407E-7 20 1415 15 6292
    regulation of primary metabolic process 1.0595E-6 20 514 10 6292
    regulation of cellular metabolic process 1.5626E-6 20 536 10 6292
    regulation of metabolic process 1.8853E-6 20 547 10 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.4493E-6 20 1566 15 6292
    primary metabolic process 4.3236E-6 20 2896 19 6292
    transcription, DNA-dependent 9.3763E-6 20 503 9 6292
    RNA biosynthetic process 1.0171E-5 20 508 9 6292
    cellular component biogenesis 1.6451E-5 20 694 10 6292
    transcription 2.0056E-5 20 552 9 6292
    metabolic process 2.082E-5 20 3157 19 6292
    DNA conformation change 2.822E-5 20 58 4 6292
    cellular component organization 3.0647E-5 20 1582 14 6292
    regulation of cellular process 5.5506E-5 20 796 10 6292
    regulation of biological process 7.5101E-5 20 824 10 6292
    cellular macromolecule metabolic process 8.1666E-5 20 2285 16 6292
    cellular metabolic process 1.0865E-4 20 3033 18 6292
    macromolecule metabolic process 1.2005E-4 20 2349 16 6292
    biological regulation 3.9439E-4 20 1213 11 6292
    chromatin silencing at telomere 6.4857E-4 20 55 3 6292
    RNA metabolic process 1.4095E-3 20 954 9 6292
    chromatin silencing at rDNA 1.4247E-3 20 18 2 6292
    chromatin modification 1.7003E-3 20 168 4 6292
    covalent chromatin modification 2.5373E-3 20 88 3 6292
    histone modification 2.5373E-3 20 88 3 6292
    double-strand break repair via nonhomologous end joining 2.7564E-3 20 25 2 6292
    histone deacetylation 3.2128E-3 20 27 2 6292
    chromatin organization 3.3944E-3 20 203 4 6292
    protein amino acid deacetylation 3.7021E-3 20 29 2 6292
    non-recombinational repair 5.067E-3 20 34 2 6292
    cellular process 8.2259E-3 20 4426 19 6292
    establishment of chromatin silencing 9.5071E-3 20 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    DNA replication origin binding 7.6335E-13 20 13 6 6292
    sequence-specific DNA binding 6.5852E-9 20 50 6 6292
    ATP-dependent DNA helicase activity 2.2085E-7 20 18 4 6292
    binding 2.5119E-7 20 1294 15 6292
    ATPase activity 2.3084E-6 20 211 7 6292
    chromatin binding 2.8643E-6 20 33 4 6292
    DNA helicase activity 3.2396E-6 20 34 4 6292
    DNA binding 8.3645E-6 20 256 7 6292
    ATP-dependent helicase activity 1.3209E-5 20 48 4 6292
    purine NTP-dependent helicase activity 1.3209E-5 20 48 4 6292
    DNA-dependent ATPase activity 2.2825E-5 20 55 4 6292
    nucleoside-triphosphatase activity 4.3039E-5 20 329 7 6292
    hydrolase activity, acting on acid anhydrides 6.7643E-5 20 353 7 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 6.7643E-5 20 353 7 6292
    pyrophosphatase activity 6.7643E-5 20 353 7 6292
    ATPase activity, coupled 8.1006E-5 20 149 5 6292
    helicase activity 1.1614E-4 20 83 4 6292
    hydrolase activity 1.003E-3 20 911 9 6292
    transcription corepressor activity 1.1216E-3 20 16 2 6292
    transcription coactivator activity 1.9443E-3 20 21 2 6292
    glutamate synthase (NADH) activity 3.1786E-3 20 1 1 6292
    homoisocitrate dehydrogenase activity 3.1786E-3 20 1 1 6292
    glutamate synthase activity, NADH or NADPH as acceptor 3.1786E-3 20 1 1 6292
    C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity 3.1786E-3 20 1 1 6292
    glutamate synthase activity 3.1786E-3 20 1 1 6292
    nucleic acid binding 3.2509E-3 20 666 7 6292
    protein deacetylase activity 4.497E-3 20 32 2 6292
    histone deacetylase activity 4.497E-3 20 32 2 6292
    deacetylase activity 5.3639E-3 20 35 2 6292
    transcription cofactor activity 6.9651E-3 20 40 2 6292
    transcription factor binding 8.0176E-3 20 43 2 6292
    transcription repressor activity 8.3834E-3 20 44 2 6292
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 9.9207E-3 20 48 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle