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Protein Overview: DIM1

General Information:
Name(s) found: DIM1 / YPL266W [SGD]
Description(s) found:
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  • gi|6324989|ref|NP_015057.1| Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA [NCBI NR]
  • gi|601876|gb|AAA57357.1| dimethyladenosine transferase [NCBI NR]
  • gi|1370549|emb|CAA98001.1| DIM1 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1169344|sp|P41819.1|DIM1_YEAST RecName: Full=Dimethyladenosine transferase; AltName: Full=S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase; AltName: Full=18S rRNA dimethylase [NCBI NR]
  • pir||S47985 rRNA (adenine-N6,N6-)-dimethyltransferase (EC 2.1.1.-) DIM1 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Dimethyladenosine transferase OS=Saccharomyces cerevisiae GN=DIM1 PE=1 SV=1 [Swiss-Prot]
  • DIM1 rRNA (adenine-N6,N6-)-dimethyltransferase [mips]
  • Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing [SGD]
  • (P41819) Dimethyladenosine transferase (EC 2.1.1.-) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) [4932.FASTACCERV.txt]
  • Chr XVI from 39121-40077 [hmr_yeast5_DM3-1_pombe.fasta]
  • DIM1, Chr XVI from 39121-40077 [yeast_orfs2]
  • DIM1 SGDID:S0006187, Chr XVI from 39121-40077, Verified ORF [yeastflysequest.fasta]
  • Dim1p [Saccharomyces cerevisiae]gi|1370549|emb|CAA98001.1| DIM1 [Saccharomyces cerevisiae]gi|1169344|sp|P41819|DIM1_YEAST Dimethyladenosine transferase (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase)gi|1078347| [nrdb_11152004_Chlamydomonas]
  • DIM1 SGDID:S000006187, Chr XVI from 39121-40077, Verified ORF, "Essential 18S rRNA dimethylase, responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18 S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosoma [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • DIM1 SGDID:S000006187, Chr XVI from 39121-40077, Verified ORF, "Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucl [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • DIM1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Essential 18S rRNA dimethylase, responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18 S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing; Dim1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Dimethyladenosine transferase (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) [nr-271106-contam.fasta]
  • dimethyladenosine transferase [nr-271106-contam.fasta]
  • DIM1 SGDID:S000006187, Chr XVI from 39121-40077, Verified ORF, "Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing" [yeast-bovrabprots.fasta]
  • DIM1 SGDID:S000006187, Chr XVI from 39121-40077, Verified ORF, "Essential 18S rRNA dimethylase, responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18 S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Dimethyladenosine transferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DIM1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • DIM1 SGDID:S000006187, Chr XVI from 39121-40077, Genome Release 64-1-1, Verified ORF, "Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing" [yeast-030211-contam.fasta]
  • DIM1 SGDID:S000006187, Chr XVI from 39121-40077, Genome Release 64-2-1, Verified ORF, "Essential 18S rRNA dimethylase (dimethyladenosine transferase); responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing" [20141208_orf_trans.fasta]
  • TR617|c0_g1_i1|g.392 ORF TR617|c0_g1_i1|g.392 TR617|c0_g1_i1|m.392 type:complete len:319 (+) TR617|c0_g1_i1:87-1043(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • TR369|c0_g1_i1|g.294 ORF TR369|c0_g1_i1|g.294 TR369|c0_g1_i1|m.294 type:complete len:319 (+) TR369|c0_g1_i1:89-1045(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta]
  • YPL266W SGDID:S000006187, Chr XVI from 39121-40077, Genome Release 64-1-1, Verified ORF, "Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • asmbl_3386|g.2651 ORF asmbl_3386|g.2651 asmbl_3386|m.2651 type:complete len:319 (+) asmbl_3386:1185-2141(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • asmbl_3433|g.2594 ORF asmbl_3433|g.2594 asmbl_3433|m.2594 type:complete len:319 (+) asmbl_3433:85-1041(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • Dimethyladenosine transferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DIM1 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
  • ID=asmbl_2988|g.1867 ORF ID=asmbl_2988|g.1867 ID=asmbl_2988|m.1867 type:complete len:319 (+) ID=asmbl_2988:1184-2140(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
  • ID=asmbl_3436|g.2288 ORF ID=asmbl_3436|g.2288 ID=asmbl_3436|m.2288 type:complete len:319 (+) ID=asmbl_3436:85-1041(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 318 amino acids

    Gene Ontology:
    Cellular Component: nuclear outer membrane [TASLink to PubMed article]
    nucleolus [TASLink to PubMed article]
    Biological Process: rRNA modification [TASLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: rRNA (adenine-N6,N6-)-dimethyltransferase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKAAKKKYS GATSSKQVSA EKHLSSVFKF NTDLGQHILK NPLVAQGIVD KAQIRPSDVV  60
   61 LEVGPGTGNL TVRILEQAKN VVAVEMDPRM AAELTKRVRG TPVEKKLEIM LGDFMKTELP 120
  121 YFDICISNTP YQISSPLVFK LINQPRPPRV SILMFQREFA LRLLARPGDS LYCRLSANVQ 180
  181 MWANVTHIMK VGKNNFRPPP QVESSVVRLE IKNPRPQVDY NEWDGLLRIV FVRKNRTISA 240
  241 GFKSTTVMDI LEKNYKTFLA MNNEMVDDTK GSMHDVVKEK IDTVLKETDL GDKRAGKCDQ 300
  301 NDFLRLLYAF HQVGIHFS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) DIM1 DIP2 EMG1 ENP1 HRR25 IMP3 LTV1 MPP10 NAN1 NOC4 PNO1 PWP2 RIO2 RPS13 RPS9A RPS9B RRP12 TSR1 UTP10 UTP4 UTP6 UTP7 UTP8
    View Details Gavin AC, et al. (2002) ADE4 ADH1 ARP9 ASC1 BEM2 BFR2 BMS1 BRX1 BUD21 CBF5 CKA1 CKA2 CKB1 CKB2 CMS1 DBP8 DIA4 DIM1 DIP2 DIS3 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 GCN1 HCA4 HHF1, HHF2 HRR25 HSL1 HTA2 IMP3 IMP4 KRE33 KRR1 LCP5 LTV1 MPP10 MRD1 MVD1 NAN1 NOB1 NOC2 NOC4 NOP1 NOP14 NOP56 NOP58 NOP6 PNO1 PRE6 PRE9 PRP43 PWP2 RCL1 RIO2 RML2 ROK1 RPP2B RRP12 RRP7 RRP9 RTG2 SAM1 SCL1 SEC21 SLX9 SNF12 SNF2 SNF5 SNF6 SOF1 SWI1 SWI3 SWP82 TIF1, TIF2 TSR1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 VPS1 YGR054W YOR059C
    View Details Ho Y, et al. (2002) DIM1 ENP1 HRP1 KAP104 MRT4 NAB2 YNL035C
    View Details Qiu et al. (2008) DIM1 NOP1 TRM112

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] PSI-BLAST 115.9897 rRNA adenine dimethylase
    2 View Details [216..318] PSI-BLAST 115.9897 rRNA adenine dimethylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • rRNA methyltransferase activity
    		•  4.09362182773099 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.00768472859991 bayes_pls_golite062009
  • methyltransferase activity
    		•  3.57681394097837 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  3.49392219433935 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.39429041855776 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  3.07428840534971 bayes_pls_golite062009
  • transferase activity
    		•  2.22303238506686 bayes_pls_golite062009
  • rRNA (guanine) methyltransferase activity
    		•  2.00108769169811 bayes_pls_golite062009
  • RNA binding
    		•  1.99752836873461 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  1.83964463328968 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  1.76571145896453 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  1.75675289134467 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  0.94499223839747 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.914549843668268 bayes_pls_golite062009
  • rRNA (uridine-2'-O-)-methyltransferase activity
    		•  0.90544396691236 bayes_pls_golite062009
  • DNA binding
    		•  0.86027591375666 bayes_pls_golite062009
  • binding
    		•  0.777596419415505 bayes_pls_golite062009
  • rRNA (uridine) methyltransferase activity
    		•  0.742142092552002 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.616949327277483 bayes_pls_golite062009
  • mRNA binding
    		•  0.0540207721800283 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.0408000230099101 bayes_pls_golite062009
  • snoRNA binding
    		•  0.00848192089639488 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle