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Protein Overview: PSH1

General Information:
Name(s) found: PSH1 / YOL054W [SGD]
Description(s) found:
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  • gi|984189|emb|CAA62533.1| Zn-finger (C3HC4) protein [Saccharomyces cerevisiae] [NCBI NR]
  • gi|74676541|sp|Q12161.1|PSH1_YEAST RecName: Full=RING finger protein PSH1; AltName: Full=POB3/SPT16 histone-associated protein 1 [NCBI NR]
  • gi|6324518|ref|NP_014587.1| Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein; Psh1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1419863|emb|CAA99062.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S59296 probable finger protein YOL054w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • RING finger protein PSH1 OS=Saccharomyces cerevisiae GN=PSH1 PE=1 SV=1 [Swiss-Prot]
  • PSH1 Nuclear protein, putative RNA polymerase II elongation factor [mips]
  • Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein [SGD]
  • >Q12161 (Q12161) Chromosome XV reading frame ORF YOL054W [4932.FASTACCERV.txt]
  • Chr XV from 228612-229832 [hmr_yeast5_DM3-1_pombe.fasta]
  • YOL054W, Chr XV from 228612-229832 [yeast_orfs2]
  • PSH1 SGDID:S0005415, Chr XV from 228612-229832, Uncharacterized ORF [yeastflysequest.fasta]
  • Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein [Saccharomyces cerevisiae]gi|984189|emb|CAA62533.1| Zn-finger (C3HC4) protein [Saccharomyces cerevisiae]gi|1419863|emb|CAA99062.1| unnamed protein pr [nrdb_11152004_Chlamydomonas]
  • (Q12161) S.cerevisiae chromosome XV reading frame ORF YOL054w (Zn-finger (C3HC4) protein) [cerv4932.FASTAC]
  • YOL054W SGDID:S000005415, Chr XV from 228612-229832, Uncharacterized ORF, "Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • YOL054W SGDID:S000005415, Chr XV from 228613-229833, Uncharacterized ORF, "Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein" [yeast-contam.fasta]
  • PSH1 SGDID:S000005415, Chr XV from 228613-229833, Uncharacterized ORF, "Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • RING finger protein PSH1 (POB3/SPT16 histone-associated protein 1) [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein; Psh1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Zn-finger (C3HC4) protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • RING finger protein PSH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PSH1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PSH1 SGDID:S000005415, Chr XV from 228614-229834, Genome Release 64-1-1, Verified ORF, "E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p" [yeast-030211-contam.fasta]
  • PSH1 SGDID:S000005415, Chr XV from 228614-229834, Genome Release 64-2-1, Verified ORF, "E3 ubiquitin ligase targeting centromere-binding protein Cse4p; mediates poyubiquitination and degradation of Cse4p; prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p" [20141208_orf_trans.fasta]
  • YOL054W SGDID:S000005415, Chr XV from 228614-229834, Genome Release 64-1-1, Verified ORF, "E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 406 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: RNA elongation from RNA polymerase II promoter [IPILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDELHNRLL HQNDGTKDAI LYKIIESLVC SICHDYMFVP MMTPCGHNYC YGCLNTWFAS  60
   61 NTQKELACPQ CRSDITTIPA LNTTLQQYLS FILEKLRDQN DESFKKLLTT KTKEENDYKN 120
  121 DKEKDTLFDK VFKNSALAVA DDSDDGITRC SNCHWELDPD EVEDGNVCPH CNARIRNYAG 180
  181 GRDEFDEEEY SEGELDEIRE SMRRRRENRF ASTNPFANRD DVSSEDDDSS EEEPMREHIP 240
  241 LGRWARSHNR SIAVDAVDDE DDEEEDEEEE EEMDSDLKDF IEDDEDDEDE DGSRRNLVLS 300
  301 ALKNRHVIIT DDEEEEQRRH ATEEEDRDSD FYEHNDDGFV SGDSLDEDQK EVTRIQSSSD 360
  361 SEDRSLSYSG SSDVKDNNDD NTEELDDPQP KRQKRFRVVL GDSDDE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ASF1 CKA1 HAT1 HAT2 HHF1, HHF2 HHT1, HHT2 HIF1 MAM33 MCM22 POB3 PSH1 SPT16
    View Details Krogan NJ, et al. (2006) ARA2 AYT1 BRO1 CDC73 CTR9 GLO4 HHT1, HHT2 LEO1 PAF1 PML39 POB3 PSH1 RTF1 SEN1 SPT16 YHR035W
    View Details Gavin AC, et al. (2006) ECM5 PSD2 PSH1 RPL38 YFR006W
    View Details Gavin AC, et al. (2002) BDF2 CDC55 CKB1 DYN1 ECM5 GLY1 HAT1 HAT2 HHF1, HHF2 HIF1 HSM3 ICL1 IML1 KAP123 KRE33 LIP2 MAC1 MDN1 MIS1 MSB1 NIP1 NMD5 PFK1 PRO1 PRT1 PSD2 PSE1 PSH1 RPA135 RPC40 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT5 RPT6 RSC3 SAM1 TEL1 TSC11 USO1 UTP20 VTH2 YFR006W YPR077C
    View Details Ho Y, et al. (2002) EDE1 GAC1 HHF1, HHF2 HTA1 HTA2 HTB1 HTB2 KNS1 MAM33 NOB1 POB3 PSH1 SPT16 SYP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIF2 No Comments Cheeseman IM, et al. (2002)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PSH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..107] PSI-BLAST 35.522879 Cbl; N-terminal domain of cbl (N-cbl); CBL
    2 View Details [108..181] PSI-BLAST 2.30103 Nuclear factor XNF7
    3 View Details [182..331] MSA 3.250986 View MSA. No confident structure predictions are available.
    4 View Details [332..406] PSI-BLAST 16.522879 TNF receptor associated factor 3 (TRAF3); TRAF3

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.3102740037962 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.72498741013971 bayes_pls_golite062009
  • protein binding
    		•  2.21219285272669 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  2.17320579037083 bayes_pls_golite062009
  • ligase activity
    		•  2.11117401820312 bayes_pls_golite062009
  • chromatin binding
    		•  1.99809307900131 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.97633825709135 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.9065986135632 bayes_pls_golite062009
  • DNA binding
    		•  1.76411499132759 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.63161912031789 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.22312570999194 bayes_pls_golite062009
  • transcription factor binding
    		•  1.11842175076436 bayes_pls_golite062009
  • transcription factor activity
    		•  1.02112227272128 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.90321253993065 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.350170315296021 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.24963159801049 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.233838999434784 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009
  • transcription activator activity
    		•  0.126093965701234 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle