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View Structure Prediction Details

Protein: PSH1
Organism: Saccharomyces cerevisiae
Length: 406 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PSH1.

Description E-value Query
Range
Subject
Range
PSH1_YEAST - RING finger protein PSH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PSH1 PE=1 SV=1
PSH1 - Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding prot...
gi|190407291 - gi|190407291|gb|EDV10558.1| hypothetical protein SCRG_01349 [Saccharomyces cerevisiae RM11-1a]
5.0E-74 [1..406] [1..406]
gi|16923932 - gi|16923932|gb|AAL31641.1|AF439153_1 Ro/SSA1 related protein FLJ10369 [Homo sapiens]
4.0E-68 [19..375] [5..351]
TRI11_MOUSE - E3 ubiquitin-protein ligase TRIM11 OS=Mus musculus GN=Trim11 PE=1 SV=1
2.0E-64 [16..369] [2..325]

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Predicted Domain #1
Region A:
Residues: [1-107]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDELHNRLL HQNDGTKDAI LYKIIESLVC SICHDYMFVP MMTPCGHNYC YGCLNTWFAS  60
   61 NTQKELACPQ CRSDITTIPA LNTTLQQYLS FILEKLRDQN DESFKKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.522879
Match: 1fbvA_
Description: Cbl; N-terminal domain of cbl (N-cbl); CBL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.3102740037962 bayes_pls_golite062009
transcription regulator activity 2.72498741013971 bayes_pls_golite062009
protein binding 2.21219285272669 bayes_pls_golite062009
small conjugating protein ligase activity 2.17320579037083 bayes_pls_golite062009
ligase activity 2.11117401820312 bayes_pls_golite062009
chromatin binding 1.99809307900131 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.97633825709135 bayes_pls_golite062009
nucleic acid binding 1.9065986135632 bayes_pls_golite062009
DNA binding 1.76411499132759 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
acid-amino acid ligase activity 1.22312570999194 bayes_pls_golite062009
transcription factor binding 1.11842175076436 bayes_pls_golite062009
transcription factor activity 1.02112227272128 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.90321253993065 bayes_pls_golite062009
transcription repressor activity 0.350170315296021 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.24963159801049 bayes_pls_golite062009
transcription cofactor activity 0.233838999434784 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009
transcription activator activity 0.126093965701234 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [108-181]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTTKTKEEND YKNDKEKDTL FDKVFKNSAL AVADDSDDGI TRCSNCHWEL DPDEVEDGNV  60
   61 CPHCNARIRN YAGG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.30103
Match: 1fre__
Description: Nuclear factor XNF7
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [182-331]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDEFDEEEYS EGELDEIRES MRRRRENRFA STNPFANRDD VSSEDDDSSE EEPMREHIPL  60
   61 GRWARSHNRS IAVDAVDDED DEEEDEEEEE EMDSDLKDFI EDDEDDEDED GSRRNLVLSA 120
  121 LKNRHVIITD DEEEEQRRHA TEEEDRDSDF 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [332-406]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YEHNDDGFVS GDSLDEDQKE VTRIQSSSDS EDRSLSYSGS SDVKDNNDDN TEELDDPQPK  60
   61 RQKRFRVVLG DSDDE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.522879
Match: 1flkA_
Description: TNF receptor associated factor 3 (TRAF3); TRAF3
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle