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Protein Overview: PFS2

General Information:
Name(s) found: PFS2 / YNL317W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 465 amino acids

    Gene Ontology:
    Cellular Component: mRNA cleavage and polyadenylation specificity factor complex [IPILink to PubMed article][TASLink to PubMed article]
    Biological Process: mRNA polyadenylation [IDALink to PubMed article][IMPLink to PubMed article][TASLink to PubMed article]
    mRNA cleavage [IDALink to PubMed article][IMPLink to PubMed article][TASLink to PubMed article]
    Molecular Function: RNA binding [ICLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGHNQNQYQ NQNQIQQSQQ PPLKKYVTQR RSVDVSSPYI NLYYNRRHGL PNLVVEPETS  60
   61 YTIDIMPPNA YRGRDRVINL PSKFTHLSSN KVKHVIPAIQ WTPEGRRLVV ATYSGEFSLW 120
  121 NASSFTFETL MQAHDSAVTT MKYSHDSDWM ISGDADGMIK IWQPNFSMVK EIDAAHTESI 180
  181 RDMAFSSNDS KFVTCSDDNI LKIWNFSNGK QERVLSGHHW DVKSCDWHPE MGLIASASKD 240
  241 NLVKLWDPRS GNCISSILKF KHTVLKTRFQ PTKGNLLMAI SKDKSCRVFD IRYSMKELMC 300
  301 VRDETDYMTL EWHPINESMF TLACYDGSLK HFDLLQNLNE PILTIPYAHD KCITSLSYNP 360
  361 VGHIFATAAK DRTIRFWTRA RPIDPNAYDD PTYNNKKING WFFGINNDIN AVREKSEFGA 420
  421 APPPPATLEP HALPNMNGFI NKKPRQEIPG IDSNIKSSTL PGLSI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CFT1 CFT2 FIP1 GLC7 MPE1 PAP1 PFS2 PTA1 PTI1 REF2 RNA14 SSU72 SWD2 YSH1 YTH1
    View Details Krogan NJ, et al. (2006) AIM1 CFT1 CFT2 ECM21 FIP1 GIP4 MPE1 PAP1 PFS2 PTA1 PTI1 REF2 SSU72 SWD2 SYC1 YBL010C YLR358C YSH1 YTH1
    View Details Gavin AC, et al. (2006) CFT1 CFT2 FIP1 MPE1 PAP1 PFS2 PTA1 YSH1 YTH1
    View Details Gavin AC, et al. (2002) ACT1 ADE4 AIM31 BFR2 BMS1 BUD21 CBF5 CFT1 CFT2 CKA1 CLP1 DBP8 DIP2 ECM16 ECM29 EMG1 ENO2 ENP1 ENP2 ERO1 ESF1 ESF2 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HSL1 HTA1 HTA2 IMP3 IMP4 KRE33 KRR1 MPE1 MPP10 MVD1 NAN1 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 PAP1 PCF11 PFK1 PFS2 PRE6 PRE9 PRP43 PTA1 PTI1 PWP2 REF2 RML2 RNA14 RNA15 ROK1 RPP2B RRP9 RSA3 RTG2 SCL1 SEC13 SEC21 SEC31 SOF1 SRO9 SSA3 SSU72 SYC1 TAF6 TIF1, TIF2 TIF4632 TYE7 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 VID24 VMR1 VPS53 YCL046W YSH1 YTH1
    View Details Ho Y, et al. (2002) CCT2 CCT5 CCT6 CFT1 HGH1 PFS2 TCP1
    View Details Qiu et al. (2008) CFT1 CFT2 CLP1 FIP1 HRP1 PAP1 PFS2 PTA1 PTI1 REF2 RNA14 RNA15 YSH1 YTH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PFS2 YKE4 1 Unpublished Fields Lab Data
    View Screen PFS2 MRP49 1 Unpublished Fields Lab Data
    View Screen PFS2 NYV1 1 Unpublished Fields Lab Data
    View Screen PFS2 MCM5 1 Unpublished Fields Lab Data
    View Screen PFS2 YLR445W 1 Unpublished Fields Lab Data
    View Screen PFS2 NTE1 1 Unpublished Fields Lab Data
    View Screen PFS2 TEM1 1 Unpublished Fields Lab Data
    View Screen PFS2 CUE1 1 Unpublished Fields Lab Data
    View Screen PFS2 URE2 1 Unpublished Fields Lab Data
    View Screen PFS2 NOP12 1 Unpublished Fields Lab Data
    View Screen PFS2 HAP3 1 Unpublished Fields Lab Data
    View Screen PFS2 RPL25 1 Unpublished Fields Lab Data
    View Screen PFS2 SHE3 1 Unpublished Fields Lab Data
    View Screen PFS2 HES1 1 Unpublished Fields Lab Data
    View Screen PFS2 MED2 1 Unpublished Fields Lab Data
    View Screen PFS2 FSF1 1 Unpublished Fields Lab Data
    View Screen PFS2 YER187W 1 Unpublished Fields Lab Data
    View Screen PFS2 RLM1 1 Unpublished Fields Lab Data
    View Screen PFS2 SIP2 1 Unpublished Fields Lab Data
    View Screen PFS2 MLC2 1 Unpublished Fields Lab Data
    View Screen PFS2 SYF2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PFS2 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..333] PSI-BLAST 224.69897 beta1-subunit of the signal-transducing G protein heterotrimer
    2 View Details [334..465] ORFEUS 13.83 No description for 1scgB was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle