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Protein Overview: HAP3

General Information:
Name(s) found: HAP3 / YBL021C [SGD]
Description(s) found:
Found 34 descriptions.
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  • Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 144 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article]
    CCAAT-binding factor complex [TASLink to PubMed article]
    Biological Process: regulation of carbohydrate metabolic process [TASLink to PubMed article]
    transcription [TASLink to PubMed article]
    Molecular Function: transcription activator activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTNESEHVS TSPEDTQENG GNASSSGSLQ QISTLREQDR WLPINNVARL MKNTLPPSAK  60
   61 VSKDAKECMQ ECVSELISFV TSEASDRCAA DKRKTINGED ILISLHALGF ENYAEVLKIY 120
  121 LAKYRQQQAL KNQLMYEQDD EEVP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) HAP3 HAP5
    View Details (MIPS) Mewes HW, et al. (2004) HAP2 HAP3 HAP4 HAP5
    View Details Krogan NJ, et al. (2006) HAP2 HAP3 HAP5
    View Details Gavin AC, et al. (2002) HAP2 HAP3 HAP5
    View Details Ho Y, et al. (2002) GSF2 HAP3 TFP1
    View Details Qiu et al. (2008) HAP2 HAP3 HAP4 HAP5

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HAP3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..144] PSI-BLAST 102.08661 Negative cofactor 2, NC2, beta chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA binding
    		•  4.24625687315724 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.08606081850613 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  4.04353148658823 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.93473976418251 bayes_pls_golite062009
  • binding
    		•  3.84636641231951 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.38228606466152 bayes_pls_golite062009
  • transcription factor activity
    		•  2.31114764804139 bayes_pls_golite062009
  • transcription activator activity
    		•  1.25487495162413 bayes_pls_golite062009
  • transcription factor binding
    		•  1.15204005455906 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.1297723528047 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.01502031330902 bayes_pls_golite062009
  • protein binding
    		•  0.978906971260821 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.72554769377984 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  0.0945459819298291 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle