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Protein Overview: HAP4

General Information:
Name(s) found: HAP4 / YKL109W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 554 amino acids

    Gene Ontology:
    Cellular Component: CCAAT-binding factor complex [TASLink to PubMed article]
    Biological Process: regulation of carbohydrate metabolic process [TASLink to PubMed article]
    transcription [TASLink to PubMed article]
    Molecular Function: transcription activator activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAKTFLLQA SASRPRSNHF KNEHNNIPLA PVPIAPNTNH HNNSSLEFEN DGSKKKKKSS  60
   61 LVVRTSKHWV LPPRPRPGRR SSSHNTLPAN NTNNILNVGP NSRNSSNNNN NNNIISNRKQ 120
  121 ASKEKRKIPR HIQTIDEKLI NDSNYLAFLK FDDLENEKFH SSASSISSPS YSSPSFSSYR 180
  181 NRKKSEFMDD ESCTDVETIA AHNSLLTKNH HIDSSSNVHA PPTKKSKLND FDLLSLSSTS 240
  241 SSATPVPQLT KDLNMNLNFH KIPHKASFPD SPADFSPADS VSLIRNHSLP TNLQVKDKIE 300
  301 DLNEIKFFND FEKLEFFNKY AKVNTNNDVN ENNDLWNSYL QSMDDTTGKN SGNYQQVDND 360
  361 DNMSLLNLPI LEETVSSGQD DKVEPDEEDI WNYLPSSSSQ QEDSSRALKK NTNSEKANIQ 420
  421 AKNDETYLFL QDQDESADSH HHDELGSEIT LADNKFSYLP PTLEELMEEQ DCNNGRSFKN 480
  481 FMFSNDTGID GSAGTDDDYT KVLKSKKIST SKSNANLYDL NDNNNDATAT NELDQSSFID 540
  541 DLDEDVDFLK VQVF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) HAP2 HAP3 HAP4 HAP5
    View Details Qiu et al. (2008) HAP2 HAP3 HAP4 HAP5

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..216] deduced N/A No confident structure predictions are available.
    2 View Details [217..554] ORFEUS 7.19 Microbial transglutaminase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.50041094056334 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.1624285999321 bayes_pls_golite062009
  • DNA binding
    		•  1.71473164736198 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.65531829577581 bayes_pls_golite062009
  • hydrolase activity
    		•  1.50020630844645 bayes_pls_golite062009
  • transcription factor activity
    		•  1.00650665223823 bayes_pls_golite062009
  • catalytic activity
    		•  0.995453662223124 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.892482498372301 bayes_pls_golite062009
  • protein binding
    		•  0.734893176227364 bayes_pls_golite062009
  • transporter activity
    		•  0.711763418431272 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.455021528561131 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.222404916967017 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.140464985591688 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0410131027210778 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.00374274471493652 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle