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Protein Overview: YKE4

General Information:
Name(s) found: YKE4 / YIL023C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 346 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: zinc ion transport [IMPLink to PubMed article]
    Molecular Function: zinc ion transmembrane transporter activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKASHICSYL LSIAPLVVSH GVHHNRDHGH EANHESKQSF LILKQESIFY SLVCFLQNHL  60
   61 FVLGPRYNAI VAILIIQLMP CLFVLFVPGL RKNDRASLTL SLLVSFSLGT LLGDILLHVI 120
  121 PESLSGVTDV TMVGGAIFLG FISFLTLDKT MRILSGTSND DGSIHSHSHS HTPQQTAEKK 180
  181 AGFNMSAYLN VISGIAHHIT DGIALATSFY SSTQVGIMTS IAVTFHEIPH ELGDFAILLS 240
  241 SGFTFPQAIR AQAVTAFGAV VGTSIGCWMN EIGNNSHKAT SSSANASELM LPFTAGGLIY 300
  301 IATTSVVPQI LHSSAPDSKL REFKKWALQL VFIFVGFAVM ALMDEH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..169] MSA 4.129992 View MSA. No confident structure predictions are available.
    2 View Details [170..346] Pfam 30.19382 ZIP Zinc transporter No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle