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Protein Overview: HES1

General Information:
Name(s) found: HES1 / YOR237W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 434 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: sterol transport [IGILink to PubMed article][IMPLink to PubMed article]
    endocytosis [IGILink to PubMed article]
    exocytosis [IGILink to PubMed article]
    Molecular Function: oxysterol binding [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQHASSSSW TSFLKSISSF NGDLSSLSAP PFILSPTSLT EFSQYWAEHP ALFLEPSLID  60
   61 GENYKDHCPF DPNVESKEVA QMLAVVRWFI STLRSQYCSR SESMGSEKKP LNPFLGEVFV 120
  121 GKWKNDEHPE FGETVLLSEQ VSHHPPMTAF SIFNEKNDVS VQGYNQIKTG FTKTLTLTVK 180
  181 PYGHVILKIK DETYLITTPP LHIEGILVAS PFVELGGRSF IQSSNGMLCV IEFSGRGYFT 240
  241 GKKNSFKARI YRSPQEHSHK ENALYLISGQ WSGVSTIIKK DSQVSHQFYD SSETPTEHLL 300
  301 VKPIEEQHPL ESRRAWKDVA EAIRQGNISM IKKTKEELEN KQRALREQER VKGVEWQRRW 360
  361 FKQVDYMNEN TSNDVEKASE DDAFRKLASK LQLSVKNVPS GTLIGGKDDK KDVSTALHWR 420
  421 FDKNLWMREN EITI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..434] Pfam 233.721246 Oxysterol-binding protein No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxysterol binding
    		•  5.62675037461468 bayes_pls_golite062009
  • sterol binding
    		•  4.18891468109664 bayes_pls_golite062009
    		• 3.02967613614595 bayes_pls_golite062009
  • steroid binding
    		•  2.54679035876403 bayes_pls_golite062009
  • phosphoinositide binding
    		•  2.2725849852584 bayes_pls_golite062009
  • binding
    		•  2.10831141109811 bayes_pls_golite062009
  • phospholipid binding
    		•  2.08170907241909 bayes_pls_golite062009
  • lipid binding
    		•  1.8520231230392 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  1.72950454023501 bayes_pls_golite062009
  • cholesterol binding
    		•  0.644339278395346 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.56

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle