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View Structure Prediction Details

Protein: HES1
Organism: Saccharomyces cerevisiae
Length: 434 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HES1.

Description E-value Query
Range
Subject
Range
HES1 - Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family w...
HES1_YEAST - Protein HES1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HES1 PE=1 SV=1
0.0 [1..434] [1..434]
OSBPL3 - oxysterol binding protein-like 3
gi|168267522 - gi|168267522|dbj|BAG09817.1| oxysterol-binding protein-related protein 3 [synthetic construct]
ENSPTRT00000035120 - null
0.0 [7..391] [526..885]
gi|9651091 - gi|9651091|dbj|BAB03558.1| hypothetical protein [Macaca fascicularis]
0.0 [7..391] [375..738]
ORP3_MOUSE, OSBL... - Oxysterol-binding protein-related protein 3 OS=Mus musculus GN=Osbpl3 PE=1 SV=1, (Q9DBS9) Oxysterol ...
0.0 [5..391] [492..853]

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Predicted Domain #1
Region A:
Residues: [1-434]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQHASSSSW TSFLKSISSF NGDLSSLSAP PFILSPTSLT EFSQYWAEHP ALFLEPSLID  60
   61 GENYKDHCPF DPNVESKEVA QMLAVVRWFI STLRSQYCSR SESMGSEKKP LNPFLGEVFV 120
  121 GKWKNDEHPE FGETVLLSEQ VSHHPPMTAF SIFNEKNDVS VQGYNQIKTG FTKTLTLTVK 180
  181 PYGHVILKIK DETYLITTPP LHIEGILVAS PFVELGGRSF IQSSNGMLCV IEFSGRGYFT 240
  241 GKKNSFKARI YRSPQEHSHK ENALYLISGQ WSGVSTIIKK DSQVSHQFYD SSETPTEHLL 300
  301 VKPIEEQHPL ESRRAWKDVA EAIRQGNISM IKKTKEELEN KQRALREQER VKGVEWQRRW 360
  361 FKQVDYMNEN TSNDVEKASE DDAFRKLASK LQLSVKNVPS GTLIGGKDDK KDVSTALHWR 420
  421 FDKNLWMREN EITI

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 233.721246
Match: PF01237
Description: Oxysterol-binding protein

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
oxysterol binding 5.62675037461468 bayes_pls_golite062009
sterol binding 4.18891468109664 bayes_pls_golite062009
3.02967613614595 bayes_pls_golite062009
steroid binding 2.54679035876403 bayes_pls_golite062009
phosphoinositide binding 2.2725849852584 bayes_pls_golite062009
binding 2.10831141109811 bayes_pls_golite062009
phospholipid binding 2.08170907241909 bayes_pls_golite062009
lipid binding 1.8520231230392 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding 1.72950454023501 bayes_pls_golite062009
cholesterol binding 0.644339278395346 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle