Protein Overview: SUI2

General Information:
Name(s) found:	SUI2 / YJR007W [SGD]
Description(s) found: Found 36 descriptions. SHOW ALL	Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP [SGD]
Organism:	Saccharomyces cerevisiae
Length:	304 amino acids
Gene Ontology:
Cellular Component:	multi-eIF complex [IDA] cytoplasm [IDA] ribosome [TAS] eukaryotic translation initiation factor 2 complex [IMP][ISS]
Biological Process:	translational initiation [TAS]
Molecular Function:	translation initiation factor activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTSHCRFYE NKYPEIDDIV MVNVQQIAEM GAYVKLLEYD NIEGMILLSE LSRRRIRSIQ  60
   61 KLIRVGKNDV AVVLRVDKEK GYIDLSKRRV SSEDIIKCEE KYQKSKTVHS ILRYCAEKFQ 120
  121 IPLEELYKTI AWPLSRKFGH AYEAFKLSII DETVWEGIEP PSKDVLDELK NYISKRLTPQ 180
  181 AVKIRADVEV SCFSYEGIDA IKDALKSAED MSTEQMQVKV KLVAAPLYVL TTQALDKQKG 240
  241 IEQLESAIEK ITEVITKYGG VCNITMPPKA VTATEDAELQ ALLESKELDN RSDSEDDEDE 300
  301 SDDE

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 HCR1 NIP1 PRT1 RPG1 SUI2 SUI3 TIF34 TIF5
View Details	(MIPS) Mewes HW, et al. (2004)		GCD11 SUI2 SUI3
View Details	Krogan NJ, et al. (2006)		ADE1 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 MRF1 MRH4 SUI2
View Details	Gavin AC, et al. (2002)		ASC1 ATG9 CCT4 CHC1 CLU1 COG8 FUN12 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 GLT1 GUT1 HCR1 IST1 IST2 KTR5 LSG1 NIP1 NOG1 NOP7 PDC1 PRO1 PRT1 RIC1 RLI1 RPG1 RRP40 RRP46 SPT5 SUA7 SUI1 SUI2 SUI3 SUP45 TIF34 TIF35 TIF5 UTP6 XKS1 YGL036W
View Details	Ho Y, et al. (2002)		CDC28 CDC33 CEG1 CFT1 CIC1 CKA1 CKA2 CKB1 CKB2 CLU1 ERB1 FAL1 FIN1 FIP1 FKH1 FPR3 FPR4 FYV8 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 GLC7 GLC8 GPH1 HER1 HHF1, HHF2 HTB1 KEL1 MBP1 MGM101 MHP1 MPH1 NET1 NOP1 NSA1 REG1 RRP1 RRP17 SCD5 SDS22 SEC2 SEN1 SIN3 SPB1 SUI2 SUI3 THR4 TIF1, TIF2 TIF4631 TIF4632 UBP12 URE2 YGR017W YMR144W YTM1
View Details	Qiu et al. (2008)		ANB1 GCD11 NIP1 PRT1 SUI1 SUI2 SUI3 TIF34 TIF35 TIF5

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	BOI1	Sample bob1 (2nd set) from october 2005	McCusker D, et al (2007)
View Run	MLP2	#25 Asynchronous Prep3-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	LSM8	SUI2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SUI2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..104]	PSI-BLAST	438.218487	Eukaryotic initiation factor 2alpha, eIF2alpha, N-terminal domain
2	View Details	[105..222]	PSI-BLAST	438.218487	Eukaryotic initiation factor 2alpha, eIF2alpha, N-terminal domain
3	View Details	[223..304]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
translation initiation factor activity	10.6089165352091	bayes_pls_golite062009
structural constituent of ribosome	6.60650180781768	bayes_pls_golite062009
translation regulator activity	6.15562485158748	bayes_pls_golite062009
structural molecule activity	6.0174879876147	bayes_pls_golite062009
DNA binding	3.38561002225202	bayes_pls_golite062009
nucleic acid binding	2.60981339834849	bayes_pls_golite062009
structure-specific DNA binding	2.50756546575713	bayes_pls_golite062009
single-stranded DNA binding	2.36609416429058	bayes_pls_golite062009
binding	2.263388192549	bayes_pls_golite062009
RNA binding	1.76502371106766	bayes_pls_golite062009
transcription regulator activity	1.69669059514663	bayes_pls_golite062009
translation factor activity, nucleic acid binding	1.60662288414996	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.33094846641297	bayes_pls_golite062009
transferase activity	0.945564658432858	bayes_pls_golite062009
mRNA binding	0.883475899526061	bayes_pls_golite062009
transcription factor activity	0.859071050218437	bayes_pls_golite062009
sequence-specific DNA binding	0.77755643935497	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	0.474251377131502	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	0.47336621289748	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	0.47336621289748	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	0.448368263932591	bayes_pls_golite062009
exoribonuclease activity	0.40142383001471	bayes_pls_golite062009
3'-5' exonuclease activity	0.33985916978927	bayes_pls_golite062009
3'-5'-exoribonuclease activity	0.16147560902991	bayes_pls_golite062009
protein binding	0.152645195799531	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2