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Protein Overview: ANB1

General Information:
Name(s) found: ANB1 / YJR047C [SGD]
Description(s) found:
Found 42 descriptions.
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  • Translation elongation factor eIF-5A, previously thought to function in translation initiation; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 157 amino acids

    Gene Ontology:
    Cellular Component: ribosome [TASLink to PubMed article]
    Biological Process: translational initiation [TASLink to PubMed article]
    Molecular Function: translation initiation factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDEEHTFEN ADAGASATYP MQCSALRKNG FVVIKGRPCK IVDMSTSKTG KHGHAKVHLV  60
   61 TLDIFTGKKL EDLSPSTHNL EVPFVKRSEY QLLDIDDGYL SLMTMDGETK DDVKAPEGEL 120
  121 GDSMQAAFDE GKDLMVTIIS AMGEEAAISF KEAPRSD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) ANB1 HYP2
    View Details Krogan NJ, et al. (2006) ANB1 ANR2 GPD2 HYP2 MEF1 MNP1 SMI1
    View Details Qiu et al. (2008) ANB1 SUI2 SUI3 TIF1, TIF2 TIF3 TIF4632 TIF5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ANB1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..85] PSI-BLAST 582.10721 No description for 1fh4A_ was found.
    2 View Details [86..157] PSI-BLAST 582.10721 No description for 1fh4A_ was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • U6 snRNA binding
    		•  7.69488393698619 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  6.60650180781768 bayes_pls_golite062009
  • structural molecule activity
    		•  6.0174879876147 bayes_pls_golite062009
  • translation initiation factor activity
    		•  5.09596850944863 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.89165617439497 bayes_pls_golite062009
  • translation elongation factor activity
    		•  3.58178742491041 bayes_pls_golite062009
  • DNA binding
    		•  3.38561002225202 bayes_pls_golite062009
  • binding
    		•  2.83465364476231 bayes_pls_golite062009
  • RNA binding
    		•  1.76502371106766 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.74890841494748 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.69669059514663 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.54386990150255 bayes_pls_golite062009
  • translation regulator activity
    		•  1.46320772716954 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  1.40718318783582 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.38349489974693 bayes_pls_golite062009
  • protein binding
    		•  1.20309946451799 bayes_pls_golite062009
  • transcription activator activity
    		•  0.990244702925461 bayes_pls_golite062009
  • mRNA binding
    		•  0.883475899526061 bayes_pls_golite062009
  • transcription factor activity
    		•  0.859071050218437 bayes_pls_golite062009
  • telomeric DNA binding
    		•  0.594907498313479 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  0.474251377131502 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  0.47336621289748 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  0.47336621289748 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.39251242706379 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.39251242706379 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.35186207828037 bayes_pls_golite062009
  • nuclease activity
    		•  0.26446253803519 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle