YRC Public Data Repository - Protein Structure Prediction

Protein:	SUI2
Organism:	Saccharomyces cerevisiae
Length:	304 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SUI2.

Description	E-value	Query Range	Subject Range
tr\|G1T2G4\|G1T2G4... - pep:known chromosome:oryCun2:20:4901008:4927649:-1 gene:ENSOCUG00000012023 transcript:ENSOCUT0000001... gi\|194038445, gi... - gi\|194038445\|ref\|XP_001928374.1\| PREDICTED: similar to eukaryotic translation initiation factor 2, s... IF2A_MOUSE - Eukaryotic translation initiation factor 2 subunit 1 OS=Mus musculus GN=Eif2s1 PE=1 SV=3 IF2A_BOVIN - Eukaryotic translation initiation factor 2 subunit 1 OS=Bos taurus GN=EIF2S1 PE=2 SV=2 IF2A_RAT - Eukaryotic translation initiation factor 2 subunit 1 OS=Rattus norvegicus GN=Eif2s1 PE=1 SV=2 gi\|57090227 - gi\|57090227\|ref\|XP_537485.1\| PREDICTED: similar to Eukaryotic translation initiation factor 2 subuni...	4.0E-61	[1..301]	[1..308]
gi\|114653567, gi... - gi\|55640927\|ref\|XP_510016.1\| PREDICTED: eukaryotic translation initiation factor 2, subunit 1 alpha,... gi\|109084000, gi... - gi\|109084000\|ref\|XP_001106000.1\| PREDICTED: eukaryotic translation initiation factor 2, subunit 1 al... gi\|123982672, gi... - gi\|123997343\|gb\|ABM86273.1\| eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa [synt... gi\|90080586 - gi\|90080586\|dbj\|BAE89774.1\| unnamed protein product [Macaca fascicularis] EIF2S1 - eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	8.0E-61	[1..301]	[1..308]
tif211 - translation initiation factor eIF2 alpha subunit IF2A_SCHPO - Eukaryotic translation initiation factor 2 subunit alpha OS=Schizosaccharomyces pombe (strain 972 / ...	1.0E-60	[1..301]	[1..302]
gi\|157423429, gi... - gi\|7739753\|gb\|AAF68997.1\|AF257517_1 eIF2 alpha subunit [Danio rerio], gi\|41351478\|gb\|AAH65879.1\| Euk...	1.0E-60	[1..301]	[1..308]
gi\|151945083 - gi\|151945083\|gb\|EDN63334.1\| translation initiation factor eIF-2 alpha subunit [Saccharomyces cerevis... SUI2 - Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start... gi\|190409494 - gi\|190409494\|gb\|EDV12759.1\| eukaryotic translation initiation factor 2 alpha subunit [Saccharomyces ... ORFP:12331 - YJR007W, Contig c301 11092-12006 IF2A_YEAST - Eukaryotic translation initiation factor 2 subunit alpha OS=Saccharomyces cerevisiae (strain ATCC 20...	2.0E-60	[1..291]	[1..291]
gi\|185134951, gi... - gi\|185134951\|ref\|NP_001117768.1\| eukaryotic initiation factor 2 alpha subunit [Oncorhynchus mykiss],...	6.0E-60	[1..301]	[1..308]
gi\|13549160 - gi\|13549160\|gb\|AAK29673.1\|AF353096_1 protein synthesis initiation factor eIF2 alpha [Arabidopsis tha...	3.0E-56	[2..302]	[6..327]
gi\|15986655, gi\|... - gi\|238665877\|emb\|CAZ36562.1\| eukaryotic translation initiation factor 2 alpha subunit, putative [Sch...	2.0E-52	[2..294]	[1..299]

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Predicted Domain #1

Region A:
Residues: [1-104]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTSHCRFYE NKYPEIDDIV MVNVQQIAEM GAYVKLLEYD NIEGMILLSE LSRRRIRSIQ  60
   61 KLIRVGKNDV AVVLRVDKEK GYIDLSKRRV SSEDIIKCEE KYQK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	438.218487
Match:	1kl9A_
Description:	Eukaryotic initiation factor 2alpha, eIF2alpha, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation initiation factor activity	10.6089165352091	bayes_pls_golite062009
structural constituent of ribosome	6.60650180781768	bayes_pls_golite062009
translation regulator activity	6.15562485158748	bayes_pls_golite062009
structural molecule activity	6.0174879876147	bayes_pls_golite062009
DNA binding	3.38561002225202	bayes_pls_golite062009
nucleic acid binding	2.60981339834849	bayes_pls_golite062009
structure-specific DNA binding	2.50756546575713	bayes_pls_golite062009
single-stranded DNA binding	2.36609416429058	bayes_pls_golite062009
binding	2.263388192549	bayes_pls_golite062009
RNA binding	1.76502371106766	bayes_pls_golite062009
transcription regulator activity	1.69669059514663	bayes_pls_golite062009
translation factor activity, nucleic acid binding	1.60662288414996	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.33094846641297	bayes_pls_golite062009
transferase activity	0.945564658432858	bayes_pls_golite062009
mRNA binding	0.883475899526061	bayes_pls_golite062009
transcription factor activity	0.859071050218437	bayes_pls_golite062009
sequence-specific DNA binding	0.77755643935497	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	0.474251377131502	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	0.47336621289748	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	0.47336621289748	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	0.448368263932591	bayes_pls_golite062009
exoribonuclease activity	0.40142383001471	bayes_pls_golite062009
3'-5' exonuclease activity	0.33985916978927	bayes_pls_golite062009
3'-5'-exoribonuclease activity	0.16147560902991	bayes_pls_golite062009
protein binding	0.152645195799531	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [105-222]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKTVHSILRY CAEKFQIPLE ELYKTIAWPL SRKFGHAYEA FKLSIIDETV WEGIEPPSKD  60
   61 VLDELKNYIS KRLTPQAVKI RADVEVSCFS YEGIDAIKDA LKSAEDMSTE QMQVKVKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	438.218487
Match:	1kl9A_
Description:	Eukaryotic initiation factor 2alpha, eIF2alpha, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [223-304]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAAPLYVLTT QALDKQKGIE QLESAIEKIT EVITKYGGVC NITMPPKAVT ATEDAELQAL  60
   61 LESKELDNRS DSEDDEDESD DE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: