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Protein Overview: POL5

General Information:
Name(s) found: POL5 / YEL055C [SGD]
Description(s) found:
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  • gi|731417|sp|P39985.1|DPO5_YEAST RecName: Full=DNA polymerase V; Short=POL V [NCBI NR]
  • gi|6320780|ref|NP_010859.1| DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA; Pol5p [Saccharomyces cer [NCBI NR]
  • gi|603263|gb|AAB65032.1| Yel055cp [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S50534 hypothetical protein YEL055c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • DNA polymerase V OS=Saccharomyces cerevisiae GN=POL5 PE=1 SV=1 [Swiss-Prot]
  • POL5 Protein required for the synthesis of rRNA [mips]
  • DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA [SGD]
  • POL5, Chr V from 48471-51539, reverse complement [yeast_orfs2]
  • Chr V from 48471-51539, reverse complement [yeastorf3.fasta]
  • Chr V from 51539-48471, reverse complement [yeastorf5.fasta]
  • (P39985) DNA polymerase V (EC 2.7.7.7) (POL V) [4932.FASTACCERV.txt]
  • POL5 SGDID:S0000781, Chr V from 51539-48471, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Pol5p [Saccharomyces cerevisiae]gi|731417|sp|P39985|DPO5_YEAST DNA polymerase V (POL V)gi|1077610|pir||S50534 hypothetical protein YEL055c - yeast (Saccharomyces cerevisiae)gi|603263|gb|AAB65032.1| Yel055cp [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • POL5 SGDID:S000000781, Chr V from 51539-48471, reverse complement, Verified ORF, "Protein with sequence similarity to the human MybBP1A and weak sequence similar to B-type DNA polymerases, not required for chromosomal DNA replication; required for the syn [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • POL5 SGDID:S000000781, Chr V from 51539-48471, reverse complement, Verified ORF, "DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; requir [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • DNA polymerase V (POL V) [nr-271106-contam.fasta]
  • Protein with sequence similarity to the human MybBP1A and weak sequence similar to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA; Pol5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Yel055cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • POL5 SGDID:S000000781, Chr V from 51539-48471, reverse complement, Verified ORF, "DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA" [yeast-bovrabprots.fasta]
  • POL5 SGDID:S000000781, Chr V from 51539-48471, reverse complement, Verified ORF, "Protein with sequence similarity to the human MybBP1A and weak sequence similar to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • DNA polymerase V OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=POL5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • POL5 SGDID:S000000781, Chr V from 51539-48471, Genome Release 64-1-1, reverse complement, Verified ORF, "DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA" [yeast-030211-contam.fasta]
  • POL5 SGDID:S000000781, Chr V from 51539-48471, Genome Release 64-2-1, reverse complement, Verified ORF, "DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA" [20141208_orf_trans.fasta]
  • YEL055C SGDID:S000000781, Chr V from 51539-48471, Genome Release 64-1-1, reverse complement, Verified ORF, "DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1022 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [IDALink to PubMed article]
    Biological Process: [NOT]DNA replication [IMPLink to PubMed article]
    rRNA transcription [IMPLink to PubMed article]
    Molecular Function: DNA-directed DNA polymerase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGKVNRDLF FKLASDLREE RLHAAVALIK DLSALDLPDD AEEWSYVLNR LIKGLSSDRN  60
   61 SARLGFSLCL TEVINLAVNM PPGQRPKGLE STNEFLSTLS TILNVNVNEG TKKSMKGKDE 120
  121 RGILFGKLFG LKSLLNEPLF SEIFVKDLEK GNTEFFIRFT EQLIDLALKK NWIKEPCFFT 180
  181 LFQTMKMLLP FMDESSAEKI LLIYDKYDLT LTNEGLSTYL LLKYEGDESL IPSVLDLKNP 240
  241 GWKDNDPLAR GNLPLLTKVL RNSSVIPDAN GGLKETKKQK NTNWNPRLHF VWSVLLPLFG 300
  301 NGKLENTSHI SKKRKKTNNK KVQNSIQFPE FWKMAVDESF FNEKASSERK YLGFLIIDAA 360
  361 FKAVPGSYIG FCFSQNVMRT LINQSIDSQR VLNKISQLTL DSIVKACEED SANRLVPCLN 420
  421 AMLFGPHGSI NFDKLTKSGT VSKLIAIKEL PSTVLAQLLD VFFLQLQDKK GVLSHTLFAL 480
  481 DSILHIVRAH KVEINDMDIM KPVLRPIVYM AFFKHTSDDL KLEQLHELAK ERLYSILGEL 540
  541 TINKEIRCKD PEINSWQYLT LKLILDIENS HVGDLINPLD ENLENIKNEA ISCLSKVCRS 600
  601 RTAQSWGLST LLSMCLVQLY AGDTDSISVI EELCEFSKHE NNSMVGITEI LLSLLAQKKA 660
  661 LLRKLSLIIW QQFIEEVGLE ELQILLDILK ARENKQGFAQ LFEGEEEFEE IKEENDASED 720
  721 ESKTGSESES ESESDSDDAD EKDEEDEANE DILNIDKEAT SALVKALNLP DNIVNDKGEV 780
  781 DLDQLEGLSD DGGDDEDEES MDDEKMMELD DQLSEIFKRR KEALSSISTG NQRKFEVKQS 840
  841 RENVISFKHR VVDMLAVYVK YCEKLTLANK SEHSNNLGGS LSKLVYFIIP MLKCVNETLD 900
  901 RPLADKISKL LKGKIFKIKV TAFKDMNKDI ELMDLLKKTH KLMLTSKPGQ HAAVFYSMCS 960
  961 TSSLFLSKLY VEIGGNDKLD ELIDLYTATT KEWMQKGKCG PNIFIDFINW LSSKKQTVMD1020
 1021 KE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) NAN1 POL5 UTP10 UTP15 UTP4 UTP5 UTP8 UTP9
    View Details Krogan NJ, et al. (2006) GFD2 NAN1 POL5 UTP10 UTP15 UTP4 UTP5 UTP8 UTP9
    View Details Gavin AC, et al. (2002) ACT1 ENO2 FPR4 NAN1 POL5 PWP1 SMC1 TYW1
    View Details Ho Y, et al. (2002) AAC3 ARP4 ASA1 ATG17 ATG29 ATP3 ATP4 BRX1 BUD3 CBF5 CBP2 CCM1 CCT2 CCT3 CCT6 CDC33 CIC1 CIN8 CIS1 CLU1 CYS4 DBP7 ENP2 FOL2 GBP2 GCN1 GRH1 HAP2 HAP5 HAS1 HIR1 HMO1 HTB1 HTB2 IMD1 IMD3 IPP1 ISA1 KRE33 KRI1 LOC1 LOS1 MAM33 MGM101 MNP1 MSS116 MTQ1 NAN1 NAP1 NMD5 NOC2 NOP12 NOP16 NOP56 NOP6 NPL3 NSA2 PET127 POL5 PRP43 PSE1 PUF6 PWP1 RHR2 RLI1 RRP12 RRP5 RVB1 SAH1 SAP190 SEC7 SPE3 SSD1 SSK2 TIF1, TIF2 TIF4631 TIF6 TMA19 TRA1 TSR1 UBA1 UBC6 URB1 URB2 UTP10 UTP20 UTP22 UTP7 YPP1 YPT1 YRA1 YRA2 YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CNS1 POL5 1 Unpublished Fields Lab Data
    View Screen YIF1 POL5 1 Unpublished Fields Lab Data
    View Screen RPA190 POL5 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data POL5 Huh WK, et al. (2003)
    View Data POL5 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..694] MSA 1.008835 View MSA. No confident structure predictions are available.
    2 View Details [695..868] MSA 5.016997 View MSA. No confident structure predictions are available.
    3 View Details [869..1022] deduced N/A No confident structure predictions are available.
    4 View Details [866..1022] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.4840129457355 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.27889073911459 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.19067997822967 bayes_pls_golite062009
  • actin binding
    		•  1.7228099998642 bayes_pls_golite062009
  • DNA binding
    		•  1.71679738414596 bayes_pls_golite062009
  • protein binding
    		•  1.41127231900194 bayes_pls_golite062009
  • transcription factor activity
    		•  1.01026749293758 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.301301625996911 bayes_pls_golite062009
  • structural molecule activity
    		•  0.279533827088985 bayes_pls_golite062009
  • RNA binding
    		•  0.243875756041061 bayes_pls_golite062009
  • transcription activator activity
    		•  0.142253868848261 bayes_pls_golite062009
  • transcription factor binding
    		•  8.79739237675814E-4 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle