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Protein Overview: MEC1

General Information:
Name(s) found: MEC1 / YBR136W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 2368 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: DNA damage checkpoint [TASLink to PubMed article]
    DNA replication checkpoint [IMPLink to PubMed article]
    reciprocal meiotic recombination [IMPLink to PubMed article]
    DNA recombination [IMPLink to PubMed article]
    telomere maintenance [IDALink to PubMed article]
    telomere maintenance via recombination [IGILink to PubMed article]
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [IGILink to PubMed article]
    Molecular Function: protein kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESHVKYLDE LILAIKDLNS GVDSKVQIKK VPTDPSSSQE YAKSLKILNT LIRNLKDQRR  60
   61 NNIMKNDTIF SKTVSALALL LEYNPFLLVM KDSNGNFEIQ RLIDDFLNIS VLNYDNYHRI 120
  121 WFMRRKLGSW CKACVEFYGK PAKFQLTAHF ENTMNLYEQA LTEVLLGKTE LLKFYDTLKG 180
  181 LYILLYWFTS EYSTFGNSIA FLDSSLGFTK FDFNFQRLIR IVLYVFDSCE LAALEYAEIQ 240
  241 LKYISLVVDY VCNRTISTAL DAPALVCCEQ LKFVLTTMHH FLDNKYGLLD NDPTMAKGIL 300
  301 RLYSLCISND FSKCFVDHFP IDQWADFSQS EHFPFTQLTN KALSIVYFDL KRRSLPVEAL 360
  361 KYDNKFNIWV YQSEPDSSLK NVTSPFDDRY KQLEKLRLLV LKKFNKTERG TLLKYRVNQL 420
  421 SPGFFQRAGN DFKLILNEAS VSIQTCFKTN NITRLTSWTV ILGRLACLES EKFSGTLPNS 480
  481 TKDMDNWYVC HLCDIEKTGN PFVRINPNRP EAAGKSEIFR ILHSNFLSHP NIDEFSESLL 540
  541 SGILFSLHRI FSHFQPPKLT DGNGQINKSF KLVQKCFMNS NRYLRLLSTR IIPLFNISDS 600
  601 HNSEDEHTAT LIKFLQSQKL PVVKENLVIA WTQLTLTTSN DVFDTLLLKL IDIFNSDDYS 660
  661 LRIMMTLQIK NMAKILKKTP YQLLSPILPV LLRQLGKNLV ERKVGFQNLI ELLGYSSKTI 720
  721 LDIFQRYIIP YAIIQYKSDV LSEIAKIMCD GDTSLINQMK VNLLKKNSRQ IFAVALVKHG 780
  781 LFSLDILETL FLNRAPTFDK GYITAYLPDY KTLAEITKLY KNSVTKDASD SENANMILCS 840
  841 LRFLITNFEK DKRHGSKYKN INNWTDDQEQ AFQKKLQDNI LGIFQVFSSD IHDVEGRTTY 900
  901 YEKLRVINGI SFLIIYAPKK SIISALAQIS ICLQTGLGLK EVRYEAFRCW HLLVRHLNDE 960
  961 ELSTVIDSLI AFILQKWSEF NGKLRNIVYS ILDTLIKEKS DLILKLKPYT TLALVGKPEL1020
 1021 GILARDGQFA RMVNKIRSTT DLIPIFANNL KSSNKYVINQ NLDDIEVYLR RKQTERSIDF1080
 1081 TPKKVGQTSD ITLVLGALLD TSHKFRNLDK DLCEKCAKCI SMIGVLDVTK HEFKRTTYSE1140
 1141 NEVYDLNDSV QTIKFLIWVI NDILVPAFWQ SENPSKQLFV ALVIQESLKY CGLSSESWDM1200
 1201 NHKELYPNEA KLWEKFNSVS KTTIYPLLSS LYLAQSWKEY VPLKYPSNNF KEGYKIWVKR1260
 1261 FTLDLLKTGT TENHPLHVFS SLIREDDGSL SNFLLPYISL DIIIKAEKGT PYADILNGII1320
 1321 IEFDSIFTCN LEGMNNLQVD SLRMCYESIF RVFEYCKKWA TEFKQNYSKL HGTFIIKDTK1380
 1381 TTNMLLRIDE FLRTTPSDLL AQRSLETDSF ERSALYLEQC YRQNPHDKNQ NGQLLKNLQI1440
 1441 TYEEIGDIDS LDGVLRTFAT GNLVSKIEEL QYSENWKLAQ DCFNVLGKFS DDPKTTTRML1500
 1501 KSMYDHQLYS QIISNSSFHS SDGKISLSPD VKEWYSIGLE AANLEGNVQT LKNWVEQIES1560
 1561 LRNIDDREVL LQYNIAKALI AISNEDPLRT QKYIHNSFRL IGTNFITSSK ETTLLKKQNL1620
 1621 LMKLHSLYDL SFLSSAKDKF EYKSNTTILD YRMERIGADF VPNHYILSMR KSFDQLKMNE1680
 1681 QADADLGKTF FTLAQLARNN ARLDIASESL MHCLERRLPQ AELEFAEILW KQGENDRALK1740
 1741 IVQEIHEKYQ ENSSVNARDR AAVLLKFTEW LDLSNNSASE QIIKQYQDIF QIDSKWDKPY1800
 1801 YSIGLYYSRL LERKKAEGYI TNGRFEYRAI SYFLLAFEKN TAKVRENLPK VITFWLDIAA1860
 1861 ASISEAPGNR KEMLSKATED ICSHVEEALQ HCPTYIWYFV LTQLLSRLLH SHQSSAQIIM1920
 1921 HILLSLAVEY PSHILWYITA LVNSNSSKRV LRGKHILEKY RQHSQNPHDL VSSALDLTKA1980
 1981 LTRVCLQDVK SITSRSGKSL EKDFKFDMNV APSAMVVPVR KNLDIISPLE SNSMRGYQPF2040
 2041 RPVVSIIRFG SSYKVFSSLK KPKQLNIIGS DGNIYGIMCK KEDVRQDNQY MQFATTMDFL2100
 2101 LSKDIASRKR SLGINIYSVL SLREDCGILE MVPNVVTLRS ILSTKYESLK IKYSLKSLHD2160
 2161 RWQHTAVDGK LEFYMEQVDK FPPILYQWFL ENFPDPINWF NARNTYARSY AVMAMVGHIL2220
 2221 GLGDRHCENI LLDIQTGKVL HVDFDCLFEK GKRLPVPEIV PFRLTPNLLD ALGIIGTEGT2280
 2281 FKKSSEVTLA LMRKNEVALM NVIETIMYDR NMDHSIQKAL KVLRNKIRGI DPQDGLVLSV2340
 2341 AGQTETLIQE ATSEDNLSKM YIGWLPFW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BZZ1 LAS17 MEC1 SLA1 VRP1
    View Details Gavin AC, et al. (2006) MEC1 VAC14
    View Details Gavin AC, et al. (2002) CLU1 CMR1 CRN1 DNA2 ECM29 HDA1 HDA2 HDA3 HSC82 KAP123 KAP95 LCD1 MEC1 MGM101 MIP6 MIS1 MLH1 MPH1 MRPL23 MRPS28 MSH2 MSH3 MSH6 NAB3 NAB6 NRD1 OLA1 PGK1 PMS1 PRO2 RAD16 RAD23 RAD34 RAD4 RAD52 RFA1 RFA2 RFA3 RIM1 RNH1 ROM2 RPA135 RPN10 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT6 RSC8 RVB2 SEN54 SGS1 SHS1 SRO7 SSL1 SUI3 SUP35 SUP45 TAO3 TFA1 TFB1 TFB4 TIF1, TIF2 TOP3 USO1 UTP20 VAC14 VAS1 VPS1 VPS5 YHR122W YJL017W
    View Details Ho Y, et al. (2002) ACO1 CLU1 GUS1 MDH1 MEC1 STI1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ECM29 MEC1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..555] deduced N/A No confident structure predictions are available.
    2 View Details [556..974] MSA 1.018981 View MSA. No confident structure predictions are available.
    3 View Details [975..1241] deduced N/A No confident structure predictions are available.
    4 View Details [1242..1376] MSA 1.040997 View MSA. Confident ab initio structure predictions are available.
    5 View Details [1377..1817] Pfam 68.026872 FAT domain No confident structure predictions are available.
    6 View Details [1818..1972] PSI-BLAST 166.9897 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
    7 View Details [1973..2133]
    [2294..2322]    		 PSI-BLAST 166.9897 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
    8 View Details [2134..2293]
    [2323..2368]    		 PSI-BLAST 166.9897 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
    9 View Details [1644..1820] PSI-BLAST 5.69897 Crystal structure of an 8 repeat consensus TPR superhelix (trigonal crystal form)
    10 View Details [1821..2368] PSI-BLAST 105.0 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  2.96084803796407 bayes_pls_golite062009
  • protein binding
    		•  2.66176697577398 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.39117996950187 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.93307188158984 bayes_pls_golite062009
  • DNA binding
    		•  1.77969838181048 bayes_pls_golite062009
  • protein transporter activity
    		•  1.51072955431931 bayes_pls_golite062009
  • protein kinase activity
    		•  1.40981221970766 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.19667256014399 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.18159704569055 bayes_pls_golite062009
  • kinase activity
    		•  1.155617721412 bayes_pls_golite062009
  • transcription factor activity
    		•  1.02508422532466 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.68280791022469 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.647706371567682 bayes_pls_golite062009
  • transferase activity
    		•  0.567560860286018 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.19278880370842 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0962597719675237 bayes_pls_golite062009
  • clathrin binding
    		•  0.0923079381755934 bayes_pls_golite062009
  • transcription activator activity
    		•  0.061709024440191 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle