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Protein Overview: NOP14

General Information:
Name(s) found: NOP14 / YDL148C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 810 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Noc4p-Nop14p complex [IPILink to PubMed article]
    nuclear outer membrane [IMPLink to PubMed article]
    nucleolus [IDALink to PubMed article]
    small nucleolar ribonucleoprotein complex [IPILink to PubMed article]
    Biological Process: maturation of SSU-rRNA [IMPLink to PubMed article][IPILink to PubMed article]
    ribosomal small subunit biogenesis [IMPLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: snoRNA binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGSQLKNLK AALKARGLTG QTNVKSKNKK NSKRQAKEYD REEKKKAIAE IREEFNPFEI  60
   61 KAARNKRRDG LPSKTADRIA VGKPGISKQI GEEQRKRAFE ARKMMKNKRG GVIDKRFGER 120
  121 DKLLTEEEKM LERFTRERQS QSKRNANLFN LEDDEDDGDM FGDGLTHLGQ SLSLEDELAN 180
  181 DEEDFLASKR FNEDDAELQQ PQRKKTKAEV MKEVIAKSKF YKQERQKAQG IMEDQIDNLD 240
  241 DNFEDVMSEL MMTQPKKNPM EPKTDLDKEY DIKVKELQLD KRAAPSDRTK TEEEKNAEAE 300
  301 EKKRELEQQR LDRMNGMIEL EEGEERGVED LDDGFWENEE DYEDDNDGIA DSDDDIKFED 360
  361 QGRDEGFSQI LKKKNISISC PRTHDALLDQ VKKLDLDDHP KIVKNIIKAY QPKLAEGNKE 420
  421 KLGKFTAVLL RHIIFLSNQN YLKNVQSFKR TQNALISILK SLSEKYNREL SEECRDYINE 480
  481 MQARYKKNHF DALSNGDLVF FSIIGILFST SDQYHLVITP ALILMSQFLE QIKFNSLKRI 540
  541 AFGAVLVRIV SQYQRISKRY IPEVVYFFQK ILLTFIVEKE NQEKPLDFEN IRLDSYELGL 600
  601 PLDVDFTKKR STIIPLHTLS TMDTEAHPVD QCVSVLLNVM ESLDATISTV WKSLPAFNEI 660
  661 ILPIQQLLSA YTSKYSDFEK PRNILNKVEK LTKFTEHIPL ALQNHKPVSI PTHAPKYEEN 720
  721 FNPDKKSYDP DRTRSEINKM KAQLKKERKF TMKEIRKDAK FEARQRIEEK NKESSDYHAK 780
  781 MAHIVNTINT EEGAEKNKYE RERKLRGGKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BFR2 BMS1 DIP2 ECM16 EMG1 ENP1 ENP2 IMP3 IMP4 KRE33 KRR1 LTV1 MAK5 MPP10 NAN1 NOC4 NOP1 NOP14 NOP56 NOP58 PWP2 RPS11A, RPS11B RPS13 RPS7A RPS8B, RPS8A RPS9B RRP12 SOF1 UTP10 UTP15 UTP20 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8
    View Details (MIPS) Mewes HW, et al. (2004) GLE2 NOP14 NUP1 NUP100 NUP116 NUP133 NUP157 NUP159 NUP170 NUP188 NUP2 NUP42 POM152
    View Details Gavin AC, et al. (2006) DIP2 EMG1 ENP1 ENP2 KRE33 KRR1 NOC4 NOP14 ROK1 UTP22 UTP6 UTP7 UTP8
    View Details Gavin AC, et al. (2002) ADE4 ADH1 ASC1 BEM2 BFR2 BMS1 BRX1 BUD21 CBF5 CFT2 CKA1 CKA2 CKB1 CKB2 CMS1 DBP8 DIA4 DIM1 DIP2 DIS3 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HRR25 HSL1 HTA2 IMP3 IMP4 KRE33 KRR1 LCP5 LTV1 MPP10 MRD1 MVD1 NAN1 NOB1 NOC2 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 PAP1 PFS2 PNO1 PRE6 PRE9 PRP43 PTA1 PTI1 PWP2 RCL1 REF2 RIO2 RML2 RNA14 ROK1 RPP2B RRP12 RRP7 RRP9 RTG2 SAM1 SCL1 SEC21 SLX9 SNF2 SNF5 SOF1 SRO9 SWI3 TIF1, TIF2 TSR1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YGR054W YOR059C YSH1
    View Details Ho Y, et al. (2002) ACC1 DMC1 DPM1 MDJ1 NOP14 RVB2 TRP3
    View Details Qiu et al. (2008) ENP1 LTV1 NOB1 NOC4 NOP14 NUP100 PWP2 RRP9 SOF1 UTP11 UTP13 UTP7 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..415] MSA 4.011926 View MSA. No confident structure predictions are available.
    2 View Details [416..810] deduced N/A No confident structure predictions are available.
    3 View Details [708..810] MSA 1.033991 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle