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Protein Overview: NOC4

General Information:
Name(s) found: NOC4 / YPR144C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 552 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Noc4p-Nop14p complex [IPILink to PubMed article]
    nuclear outer membrane [IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed article]
    nucleolus [IDALink to PubMed articleLink to PubMed article]
    small nucleolar ribonucleoprotein complex [IPILink to PubMed article]
    Biological Process: ribosomal small subunit biogenesis [IMPLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLLISEIKD IAKRLTAAGD RKQYNSIIKL INELVIPENV TQLEEDETEK NLRFLVMSLF  60
   61 QIFRKLFSRG DLTLPSSKKS TLEKEQFVNW CRKVYEAFKT KLLAIISDIP FETSLGLDSL 120
  121 DVYLQLAELE STHFASEKGA PFFPNKTFRK LIIALWSSNM GEIEDVKSSG ASENLIIVEF 180
  181 TEKYYTKFAD IQYYFQSEFN QLLEDPAYQD LLLKNVGKWL ALVNHDKHCS SVDADLEIFV 240
  241 PNPPQAIENE SKFKSNFEKN WLSLLNGQLS LQQYKSILLI LHKRIIPHFH TPTKLMDFLT 300
  301 DSYNLQSSNK NAGVVPILAL NGLFELMKRF NLEYPNFYMK LYQIINPDLM HVKYRARFFR 360
  361 LMDVFLSSTH LSAHLVASFI KKLARLTLES PPSAIVTVIP FIYNLIRKHP NCMIMLHNPA 420
  421 FISNPFQTPD QVANLKTLKE NYVDPFDVHE SDPELTHALD SSLWELASLM EHYHPNVATL 480
  481 AKIFAQPFKK LSYNMEDFLD WNYDSLLNAE SSRKLKTLPT LEFEAFTNVF DNEDGDSEAS 540
  541 SQGNVYLPGV AW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BFR2 BMS1 DIM1 DIP2 ECM16 EMG1 ENP1 ENP2 IMP3 IMP4 KRE33 KRR1 MPP10 NAN1 NOC4 NOP1 NOP14 NOP56 PNO1 PWP2 ROK1 RPS7A RRP12 RRP9 SOF1 UTP10 UTP13 UTP15 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9
    View Details Krogan NJ, et al. (2006) BYE1 MLP2 NOC4 RIF1 TIF3
    View Details Gavin AC, et al. (2006) DIP2 EMG1 ENP1 ENP2 KRE33 KRR1 NOC4 NOP14 ROK1 UTP22 UTP6 UTP7
    View Details Gavin AC, et al. (2002) ADE4 ADH1 ASC1 BEM2 BFR2 BMS1 BRX1 BUD21 CBF5 CFT2 CKA1 CKA2 CKB1 CKB2 CMS1 DBP8 DIA4 DIM1 DIP2 DIS3 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HRR25 HSL1 HTA2 IMP3 IMP4 KRE33 KRR1 LCP5 LTV1 MPP10 MRD1 MVD1 NAN1 NOB1 NOC2 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 PAP1 PFS2 PNO1 PRE6 PRE9 PRP43 PTA1 PTI1 PWP2 RCL1 REF2 RIO2 RML2 RNA14 ROK1 RPP2B RRP12 RRP7 RRP9 RTG2 SAM1 SCL1 SEC21 SLX9 SNF2 SNF5 SOF1 SRO9 SWI3 TIF1, TIF2 TSR1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YGR054W YOR059C YSH1
    View Details Qiu et al. (2008) DBP6 ENP1 LTV1 NOB1 NOC4 NOP14 PWP2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ARF2 NOC4 2 Unpublished Fields Lab Data
    View Screen CAB2 NOC4 1 Unpublished Fields Lab Data
    View Screen UBC7 NOC4 1 Unpublished Fields Lab Data
    View Screen BNI1 NOC4 1 Unpublished Fields Lab Data
    View Screen ARF3 NOC4 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data NOC4 and SPC42 Unpublished Data
    View Data NOC4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..425] ORFEUS 9.09 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    2 View Details [426..552] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle