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Protein Overview: CAB2

General Information:
Name(s) found: CAB2 / YIL083C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 365 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: coenzyme A biosynthetic process [ISSLink to PubMed article]
    Molecular Function: phosphopantothenate--cysteine ligase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPLPVLNRP QIHTSVTEIS HAIDRTIKEE LFPVAYTTEE EQYFKTNPKP AYIDELIKDA  60
   61 KEFIDLQYSL KRNKIVLITS GGTTVPLENN TVRFIDNFSA GTRGASSAEQ FLANGYSVIF 120
  121 LHREFSLTPY NRSFSHSINT LFLDYIDSEG KIKPEFAENV LKNKKLYDKY MEKEEKLLLL 180
  181 PFTTVNQYLW SLKSIAKLLN NSGCLFYLAA AVSDFFVPYS RLPQHKIQSG DNGKMGANND 240
  241 TEGTTRTTPD GKLIVNLDPV PKFLRRLVES WATQAMIVSF KLETDESMLL YKCTQALDRY 300
  301 NHQLVIGNLL QTRNKQVIFV SPENRKGDWV RLDEKHHIIE EMIIPEVIAR HDKWVAHSKT 360
  361 KLATK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CAB2 No Comments Hazbun TR, et al. (2003)
    View Run ASF1 3829 - low filter Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CAB2 and SPC42 Hazbun TR, et al. (2003)
    View Data CAB2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80] PSI-BLAST 14.0 4'-phosphopantothenoylcysteine decarboxylase (PPC decarboxylase, halotolerance protein Hal3a)
    2 View Details [81..365] MSA 3.065961 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • phosphopantothenate--cysteine ligase activity
    		•  5.69075768451173 bayes_pls_golite062009
  • phosphopantothenoylcysteine decarboxylase activity
    		•  5.47152792211468 bayes_pls_golite062009
  • ligase activity
    		•  2.22669253992824 bayes_pls_golite062009
  • binding
    		•  1.89072001556053 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.60765845284251 bayes_pls_golite062009
  • catalytic activity
    		•  1.32370671504792 bayes_pls_golite062009
  • carboxy-lyase activity
    		•  1.28899846789805 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  0.53776941010038 bayes_pls_golite062009
  • protein binding
    		•  0.395135807048731 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.133284065682966 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle