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Catalysis of the reaction: 3-sulfopyruvate = 2-sulfoacetaldehyde + CO2. Catalysis of the reaction: 4-hydroxyphenylpyruvate = 4-hydroxyphenylacetaldehyde + CO2. Catalysis of the reaction: carnitine = 2-methylcholine + CO2. Catalysis of the reaction: 6-methylsalicylate = 3-cresol + CO2. Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2. Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine = pantetheine + CO2. Catalysis of the reaction: meso-2,6-diaminoheptanedioate = L-lysine + CO2. Catalysis of the reaction: N-((R)-4-phosphopantothenoyl)-L-cysteine = pantetheine 4'-phosphate + CO2. Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2. Catalysis of the reaction: 2,5-dihydroxybenzoate = hydroquinone + CO2. Catalysis of the reaction: 3,4-dihydroxybenzoate = catechol + CO2. Catalysis of the reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2. Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2. Catalysis of the reaction: 3-phosphonopyruvate = 2-phosphonoacetaldehyde + CO2. Catalysis of the reaction: L-aspartate = beta-alanine + CO2. Catalysis of the reaction: dimethylmalonate + H+ = isobutyrate + CO2. Catalysis of the reaction: stipitatonate = stipitatate + CO2. Catalysis of the reaction: 2,4-dihydroxy-6-methylbenzoate = orcinol + CO2. Catalysis of the reaction: L-tyrosine = tyramine + CO2. Catalysis of the reaction: L-arginine = agmatine + CO2. Catalysis of the reaction: 3-oxododecanoate = 2-undecanone + CO2. Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. Catalysis of the reaction: malonate semialdehyde + H+ = acetaldehyde + CO2. Catalysis of the reaction: L-threonine O-3-phosphate = (R)-1-aminopropan-2-yl phosphate + CO2. Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2. Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2. Catalysis of the reaction: 3-dehydro-L-gulonate = L-xylulose + CO2. Catalysis of the reaction: 4,4-dimethyl-3-oxopentanoate + H+ = 3,3-dimethyl-2-butanone + CO2. Catalysis of the reaction: orotidine 5'-phosphate = UMP + CO2. Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoate + H+ = 2,2-dimethyl-3-pentanone + CO2. Catalysis of the reaction: L-histidine = histamine + CO2. Catalysis of the reaction: L-valine = 2-methylpropanamine + CO2. Catalysis of the reaction: 5-guanidino-2-oxo-pentanoate = CO2 + 4-guanidinobutanoate. Catalysis of the reaction: indolepyruvate = CO2 + indole acetaldehyde. Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate. Catalysis of the reaction: uracil 5-carboxylate = uracil + CO2. Catalysis of the reaction: 2-aryl-2-methylmalonate = CO2 + 2-arylpropionate. Catalysis of the reaction: 3-hydroxy-L-glutamate = 4-amino-3-hydroxybutanoate + CO2. Catalysis of the reaction: hydroxypyruvate = glycolaldehyde + CO2. Catalysis of the reaction: dihydroxyfumarate = tartronate semialdehyde + CO2. Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. Catalysis of the reaction: L-ornithine = putrescine + CO2. Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2. Catalysis of the reaction: 2,2-dialkylglycine + pyruvate = dialkyl ketone + L-alanine + CO2. Catalysis of the reaction: (3S)-3-methyl-2-oxopentanoate = 2-methylbutanal + CO2. Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2. Catalysis of the reaction: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate = CO2 + 3-hydroxy-2-methylpyridine-5-carboxylate. Catalysis of the reaction: UDP-D-galacturonate = UDP-L-arabinose + CO2. Catalysis of the reaction: L-tryptophan = tryptamine + CO2. Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate. Catalysis of the reaction: H2O + acetylenedicarboxylate = CO2 + pyruvate. Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde. Catalysis of the reaction: pent-2-enoyl-CoA = but-2-enoyl-CoA + CO2. Catalysis of the reaction: 2,3,6-trihydroxyisonicotinate = 2,3,6-trihydroxypyridine + CO2. Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate. Catalysis of the reaction: 3,4-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2. Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2. Catalysis of the reaction: (4-hydroxyphenyl)acetate + H+ = 4-methylphenol + CO2. Catalysis of the reaction: phenanthrene-4,5-dicarboxylate + H+ = phenanthrene-4-carboxylate + CO2. Catalysis of the reaction: cis-aconitate = itaconate + CO2. Catalysis of the reaction: phosphatidyl-L-serine = phosphatidylethanolamine + CO2. Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O. Catalysis of the reaction: 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate = 2-aminomuconate semialdehyde + CO2. Catalysis of the reaction: (R,R)-tartrate = D-glycerate + CO2. Catalysis of the reaction: L-aspartate = L-alanine + CO2. Catalysis of the reaction: L-methionine = 3-methylthiopropanamine + CO2. Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2. Catalysis of the reaction: acetoacetate + H+ = acetone + CO2. Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2. Catalysis of the reaction: oxalyl-CoA = formyl-CoA + CO2. Catalysis of the reaction: oxaloacetate = pyruvate + CO2. Catalysis of the reaction: 3,4-dihydroxyphthalate + H+ = 3,4-dihydroxybenzoate + CO2. Catalysis of the reaction: 2,3-dihydroxybenzoate + H+ = CO2 + catechol. Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM. Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate. null Catalysis of the reaction: 3,4,5-trihydroxybenzoate = pyrogallol + CO2. Catalysis of the reaction: 4-hydroxybenzoate = phenol + CO2. Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol. Catalysis of the reaction: 2 glyoxylate = tartronate semialdehyde + CO2. Catalysis of the reaction: 2-hydroxyisophthalic acid = salicylate + CO2. Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol. Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2. Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate. Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2. Catalysis of the reaction: pryrole-2-carboxylate + H+ = pyrrole + CO2. Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. Catalysis of the reaction: UDP-D-glucuronic acid = UDP-D-xylose + CO2. Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2. Catalysis of the reaction: oxalate = formate + CO2. Catalysis of the reaction: terephthalate + H2O = benzoate + HCO3-. Catalysis of the reaction: 2,3-dihydroxybenzoate = catechol + CO2. Catalysis of the reaction: D-dopachrome = 5,6-dihydroxyindole + CO2. Catalysis of the reaction: 3-dehydro-L-gulonate 6-phosphate + H+ = L-xylulose 5-phosphate + CO2. Catalysis of the reaction: L-2,4-diaminobutanoate = propane-1,3-diamine + CO2. Catalysis of the reaction: benzoylformate = benzaldehyde + CO2. Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. Catalysis of the reaction: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 4,5-dihydro-5-oxofuran-2-acetate + CO2. Catalysis of the reaction: S-adenosyl-L-methionine = (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt + CO2. Catalysis of the reaction: 2-oxoglutarate = succinate semialdehyde + CO2. Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2. Catalysis of the reaction: L-lysine = cadaverine + CO2.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: carboxy-lyase activity
Acc: GO:0016831
Aspect: Molecular Function
Desc: Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
Synonyms:
  • decarboxylase activity
Proteins in PDR annotated with:
   This term: 99 [Search]
   Term or descendants: 476 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016831 - carboxy-lyase activity (interactive image map)
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Created and Maintained by: Michael Riffle