YRC Public Data Repository - Protein Structure Prediction

Protein:	CAB2
Organism:	Saccharomyces cerevisiae
Length:	365 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CAB2.

Description	E-value	Query Range	Subject Range
CAB2 - Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme ...	0.0	[1..365]	[1..365]
gi\|8778623 - gi\|8778623\|gb\|AAF79631.1\|AC025416_5 F5O11.7 [Arabidopsis thaliana]	6.0E-77	[14..360]	[85..455]
gi\|15978163, gi\|... - gi\|16120401\|ref\|NP_403714.1\| phosphopantothenoylcysteine synthase/decarboxylase [Yersinia pestis CO9... gi\|150260888, gi... - gi\|150260888\|ref\|ZP_01917616.1\| DNA/pantothenate metabolism flavoprotein [Yersinia pestis CA88-4125]... gi\|51594403, gi\|... - gi\|51594403\|ref\|YP_068594.1\| phosphopantothenoylcysteine synthase/decarboxylase [Yersinia pseudotube... Q66GD7\|Q66GD7_YERPS - DNA/pantothenate metabolism flavoprotein - Yersinia pseudotuberculosis gi\|165936230, gi... - gi\|165936230\|ref\|ZP_02224799.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|45434769, gi\|... - gi\|45439914\|ref\|NP_991453.1\| phosphopantothenoylcysteine synthase/decarboxylase [Yersinia pestis bio... gi\|25322282 - pir\|\|AI0006 DNA/pantothenate metabolism flavoprotein [imported] - Yersinia pestis (strain CO92)	2.0E-72	[4..353]	[118..401]
COABC_HAEIN - Coenzyme A biosynthesis bifunctional protein CoaBC OS=Haemophilus influenzae (strain ATCC 51907 / DS... DFP_HAEIN, COABC... - (P44953) Coenzyme A biosynthesis bifunctional protein coaBC (DNA/pantothenate metabolism flavoprotei...	7.0E-72	[4..353]	[116..398]
SPCC4B3.18 - phosphopantothenate-cysteine ligase YJ2I_SCHPO - Uncharacterized protein C4B3.18 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC4B3.18...	8.0E-71	[42..357]	[9..311]
gi\|18389124 - gi\|18389124\|gb\|AAL47573.1\| DNA flavoprotein Dfp [Pyrococcus furiosus] gi\|18977812, gi\|... - gi\|18977812\|ref\|NP_579169.1\| bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothen...	2.0E-70	[2..348]	[128..402]
gi\|227012062, gi... - gi\|75828206\|ref\|ZP_00757641.1\| COG0452: Phosphopantothenoylcysteine synthetase/decarboxylase [Vibrio... gi\|121629717, gi... - gi\|75816559\|ref\|ZP_00747026.1\| COG0452: Phosphopantothenoylcysteine synthetase/decarboxylase [Vibrio... COABC_VIBCH - Coenzyme A biosynthesis bifunctional protein CoaBC OS=Vibrio cholerae serotype O1 (strain ATCC 39315... COABC_VIBCH - Coenzyme A biosynthesis bifunctional protein CoaBC OS=Vibrio cholerae GN=coaBC PE=3 SV=1 gi\|116189166, gi... - gi\|254851344\|ref\|ZP_05240694.1\| bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantot... gi\|121591478, gi... - gi\|121591478\|ref\|ZP_01678750.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|153222613, gi... - gi\|153222613\|ref\|ZP_01953317.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|124123665, gi... - gi\|153800834\|ref\|ZP_01955420.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|227080435, gi... - gi\|227080435\|ref\|YP_002808986.1\| DNA/pantothenate metabolism flavoprotein [Vibrio cholerae M66-2], g... gi\|126509506, gi... - gi\|153819942\|ref\|ZP_01972609.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|229506984, gi... - gi\|229506984\|ref\|ZP_04396492.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenoylcystein... gi\|229509354, gi... - gi\|229509354\|ref\|ZP_04398837.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenoylcystein... gi\|229346727, gi... - gi\|229516301\|ref\|ZP_04405749.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenoylcystein... gi\|229606492, gi... - gi\|229606492\|ref\|YP_002877140.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenoylcystei...	1.0E-69	[3..335]	[116..386]
gi\|15603018, gi\|... - gi\|15603018\|ref\|NP_246090.1\| bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothen...	4.0E-69	[4..353]	[117..399]
gi\|13375919, gi\|... - gi\|13375919\|ref\|NP_078940.1\| phosphopantothenoylcysteine synthetase [Homo sapiens], gi\|10433192\|dbj\|...	8.0E-69	[58..334]	[20..284]

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Predicted Domain #1

Region A:
Residues: [1-80]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPLPVLNRP QIHTSVTEIS HAIDRTIKEE LFPVAYTTEE EQYFKTNPKP AYIDELIKDA  60
   61 KEFIDLQYSL KRNKIVLITS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.0
Match:	1e20A_
Description:	4'-phosphopantothenoylcysteine decarboxylase (PPC decarboxylase, halotolerance protein Hal3a)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [81-365]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGTTVPLENN TVRFIDNFSA GTRGASSAEQ FLANGYSVIF LHREFSLTPY NRSFSHSINT  60
   61 LFLDYIDSEG KIKPEFAENV LKNKKLYDKY MEKEEKLLLL PFTTVNQYLW SLKSIAKLLN 120
  121 NSGCLFYLAA AVSDFFVPYS RLPQHKIQSG DNGKMGANND TEGTTRTTPD GKLIVNLDPV 180
  181 PKFLRRLVES WATQAMIVSF KLETDESMLL YKCTQALDRY NHQLVIGNLL QTRNKQVIFV 240
  241 SPENRKGDWV RLDEKHHIIE EMIIPEVIAR HDKWVAHSKT KLATK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
phosphopantothenate--cysteine ligase activity	5.69075768451173	bayes_pls_golite062009
phosphopantothenoylcysteine decarboxylase activity	5.47152792211468	bayes_pls_golite062009
ligase activity	2.22669253992824	bayes_pls_golite062009
binding	1.89072001556053	bayes_pls_golite062009
acid-amino acid ligase activity	1.60765845284251	bayes_pls_golite062009
catalytic activity	1.32370671504792	bayes_pls_golite062009
carboxy-lyase activity	1.28899846789805	bayes_pls_golite062009
carbon-carbon lyase activity	0.53776941010038	bayes_pls_golite062009
protein binding	0.395135807048731	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.133284065682966	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: