YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Gavin A.C. et al. (2002) Abstract Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7.
Notes:	From the published set of protein complexes.
Complex Size:	26 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
AHA1	cytoplasm	protein folding response to stress	chaperone binding chaperone activator activity ATPase activator activity
ATP11	mitochondrial matrix mitochondrion	protein complex assembly	unfolded protein binding
CAF130	CCR4-NOT complex	regulation of transcription from RNA polymerase II promoter	molecular_function
CAF40	CCR4-NOT complex	regulation of transcription from RNA polymerase II promoter	molecular_function
CCR4	cytoplasm Cdc73/Paf1 complex CCR4-NOT core complex	response to drug traversing start control point of mitotic cell cycle nuclear-transcribed mRNA poly(A) tail shortening nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of transcription from RNA polymerase II promoter RNA elongation from RNA polymerase II promoter	3'-5'-exoribonuclease activity
CCT6	chaperonin-containing T-complex cytoskeleton cytoplasm	cytoskeleton organization protein folding	unfolded protein binding
CDC36	nucleus cytoplasm CCR4-NOT core complex	negative regulation of transcription from RNA polymerase II promoter response to pheromone involved in conjugation with cellular fusion nuclear-transcribed mRNA poly(A) tail shortening nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of transcription from RNA polymerase II promoter RNA elongation from RNA polymerase II promoter protein ubiquitination	ubiquitin-protein ligase activity 3'-5'-exoribonuclease activity
CDC39	nucleus cytoplasm CCR4-NOT core complex	negative regulation of transcription from RNA polymerase II promoter response to pheromone involved in conjugation with cellular fusion pseudohyphal growth nuclear-transcribed mRNA poly(A) tail shortening nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of transcription from RNA polymerase II promoter RNA elongation from RNA polymerase II promoter	3'-5'-exoribonuclease activity
COP1	COPI vesicle coat	ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER	molecular_function
FAS2	fatty acid synthase complex mitochondrion	protein-cofactor linkage fatty acid biosynthetic process	3-oxoacyl-[acyl-carrier-protein] synthase activity 3-oxoacyl-[acyl-carrier-protein] reductase activity holo-[acyl-carrier-protein] synthase activity
GCN1	mitochondrion cytosol	regulation of translational elongation	molecular_function
MOT2	cytoplasm CCR4-NOT core complex	conjugation with cellular fusion telomere maintenance nuclear-transcribed mRNA poly(A) tail shortening regulation of transcription from RNA polymerase II promoter RNA elongation from RNA polymerase II promoter protein ubiquitination	ubiquitin-protein ligase activity 3'-5'-exoribonuclease activity transcription repressor activity
NOT3	cytoplasm CCR4-NOT core complex	nuclear-transcribed mRNA poly(A) tail shortening regulation of transcription from RNA polymerase II promoter protein ubiquitination	ubiquitin-protein ligase activity 3'-5'-exoribonuclease activity
NOT5	cytoplasm CCR4-NOT core complex	nuclear-transcribed mRNA poly(A) tail shortening regulation of transcription from RNA polymerase II promoter RNA elongation from RNA polymerase II promoter protein ubiquitination	ubiquitin-protein ligase activity 3'-5'-exoribonuclease activity
PDC1	nucleus cytoplasm cytosol	pyruvate metabolic process glucose catabolic process to ethanol	pyruvate decarboxylase activity
POL1	replication fork alpha DNA polymerase:primase complex mitochondrion	DNA replication initiation lagging strand elongation DNA replication DNA synthesis involved in DNA repair premeiotic DNA synthesis	nucleic acid binding nucleotide binding DNA binding DNA-directed DNA polymerase activity nucleotidyltransferase activity transferase activity nucleoside binding
POL12	nuclear envelope nucleus alpha DNA polymerase:primase complex	DNA replication initiation lagging strand elongation telomere capping	DNA binding DNA-directed DNA polymerase activity
POP2	cytoplasm CCR4-NOT core complex	nuclear-transcribed mRNA poly(A) tail shortening regulation of transcription from RNA polymerase II promoter RNA elongation from RNA polymerase II promoter	3'-5'-exoribonuclease activity
PRI1	alpha DNA polymerase:primase complex	DNA replication initiation lagging strand elongation DNA replication DNA replication, synthesis of RNA primer	DNA primase activity
PRI2	nuclear envelope nucleus alpha DNA polymerase:primase complex	DNA replication initiation lagging strand elongation DNA replication DNA synthesis involved in DNA repair DNA replication, synthesis of RNA primer	DNA primase activity
RVB2	nucleus Swr1 complex Ino80 complex nuclear outer membrane chromatin remodeling complex	chromatin remodeling snoRNA metabolic process regulation of transcription from RNA polymerase II promoter	ATPase activity ATP-dependent 5'-3' DNA helicase activity
SAM1	cytoplasm	methionine metabolic process	methionine adenosyltransferase activity
SEC27	COPI vesicle coat	ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER	molecular_function
TFC7	transcription factor TFIIIC complex	transcription initiation from RNA polymerase III promoter	RNA polymerase III transcription factor activity
TFP1	vacuolar proton-transporting V-type ATPase, V1 domain fungal-type vacuole membrane	protein metabolic process vacuolar acidification intron homing	proton-transporting ATPase activity, rotational mechanism endodeoxyribonuclease activity
YRA1	transcription export complex	mRNA export from nucleus	RNA binding

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
CCR4-NOT complex	1.4592E-19	26	14	9	6292
CCR4-NOT core complex	6.7982E-17	26	8	7	6292
transcription factor complex	7.9978E-14	26	71	10	6292
protein complex	5.5499E-12	26	1137	21	6292
macromolecular complex	7.4895E-9	26	1635	21	6292
alpha DNA polymerase:primase complex	7.9529E-9	26	7	4	6292
nucleoplasm part	2.0472E-8	26	245	10	6292
nucleoplasm	4.185E-8	26	264	10	6292
nuclear part	6.5462E-7	26	1103	16	6292
replisome	6.742E-7	26	18	4	6292
nuclear replisome	6.742E-7	26	18	4	6292
nuclear replication fork	1.0615E-6	26	20	4	6292
nuclear lumen	6.2983E-6	26	453	10	6292
replication fork	2.3056E-5	26	42	4	6292
intracellular organelle part	2.7343E-5	26	2282	20	6292
organelle part	2.7343E-5	26	2282	20	6292
organelle lumen	2.7446E-5	26	660	11	6292
intracellular organelle lumen	2.7446E-5	26	660	11	6292
membrane-enclosed lumen	4.7864E-5	26	700	11	6292
protein-DNA complex	7.8016E-5	26	57	4	6292
nucleus	5.6527E-4	26	2041	17	6292
COPI coated vesicle membrane	5.8072E-4	26	9	2	6292
COPI vesicle coat	5.8072E-4	26	9	2	6292
nuclear chromosome part	9.3441E-4	26	190	5	6292
intracellular organelle	1.3269E-3	26	4070	24	6292
organelle	1.3337E-3	26	4071	24	6292
membrane-bounded organelle	1.5311E-3	26	3771	23	6292
intracellular membrane-bounded organelle	1.5311E-3	26	3771	23	6292
intracellular part	1.8099E-3	26	4938	26	6292
Golgi-associated vesicle membrane	1.9016E-3	26	16	2	6292
nuclear chromosome	2.1079E-3	26	228	5	6292
intracellular	2.1987E-3	26	4975	26	6292
chromosomal part	2.4982E-3	26	237	5	6292
COPI-coated vesicle	3.2858E-3	26	21	2	6292
chromosome	4.6754E-3	26	274	5	6292
fatty acid synthase complex	8.248E-3	26	2	1	6292
vesicle coat	8.4934E-3	26	34	2	6292
coated vesicle membrane	8.9854E-3	26	35	2	6292
cytoplasmic vesicle membrane	8.9854E-3	26	35	2	6292
vesicle membrane	8.9854E-3	26	35	2	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
nuclear-transcribed mRNA poly(A) tail shortening	6.7982E-17	26	8	7	6292
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	7.1755E-12	26	27	7	6292
mRNA 3'-end processing	2.1023E-11	26	31	7	6292
nuclear-transcribed mRNA catabolic process	9.904E-11	26	38	7	6292
RNA 3'-end processing	2.0948E-10	26	42	7	6292
mRNA catabolic process	7.7965E-9	26	69	7	6292
RNA elongation from RNA polymerase II promoter	7.9832E-9	26	39	6	6292
regulation of transcription from RNA polymerase II promoter	1.0241E-8	26	228	10	6292
RNA elongation	1.9605E-8	26	45	6	6292
RNA biosynthetic process	2.0831E-8	26	508	13	6292
RNA catabolic process	2.2293E-8	26	80	7	6292
transcription from RNA polymerase II promoter	3.9626E-7	26	335	10	6292
regulation of gene expression	5.7246E-7	26	445	11	6292
lagging strand elongation	6.742E-7	26	18	4	6292
regulation of macromolecule biosynthetic process	7.3217E-7	26	456	11	6292
regulation of transcription, DNA-dependent	7.3454E-7	26	358	10	6292
regulation of RNA metabolic process	8.3513E-7	26	363	10	6292
regulation of cellular biosynthetic process	1.0351E-6	26	472	11	6292
regulation of biosynthetic process	1.0573E-6	26	473	11	6292
regulation of transcription	1.4023E-6	26	384	10	6292
regulation of macromolecule metabolic process	1.4445E-6	26	488	11	6292
cellular macromolecule biosynthetic process	1.8366E-6	26	1187	16	6292
macromolecule biosynthetic process	1.8802E-6	26	1189	16	6292
transcription, DNA-dependent	1.9525E-6	26	503	11	6292
mRNA processing	2.2282E-6	26	156	7	6292
regulation of primary metabolic process	2.4198E-6	26	514	11	6292
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	2.8516E-6	26	415	10	6292
regulation of nitrogen compound metabolic process	2.9147E-6	26	416	10	6292
regulation of cellular metabolic process	3.6602E-6	26	536	11	6292
regulation of metabolic process	4.4691E-6	26	547	11	6292
transcription	4.8863E-6	26	552	11	6292
DNA strand elongation	6.6845E-6	26	31	4	6292
DNA strand elongation involved in DNA replication	6.6845E-6	26	31	4	6292
DNA replication initiation	8.6445E-6	26	33	4	6292
cellular biosynthetic process	1.4754E-5	26	1567	17	6292
mRNA metabolic process	1.7541E-5	26	213	7	6292
biosynthetic process	2.0237E-5	26	1602	17	6292
nucleic acid metabolic process	2.0407E-5	26	1415	16	6292
cellular macromolecule metabolic process	2.7959E-5	26	2285	20	6292
RNA metabolic process	3.1241E-5	26	954	13	6292
macromolecule metabolic process	4.4559E-5	26	2349	20	6292
primary metabolic process	5.527E-5	26	2896	22	6292
cellular macromolecule catabolic process	7.1699E-5	26	265	7	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	7.8192E-5	26	1566	16	6292
cellular nitrogen compound metabolic process	8.2318E-5	26	1770	17	6292
nitrogen compound metabolic process	9.6909E-5	26	1791	17	6292
DNA synthesis involved in DNA repair	9.8027E-5	26	4	2	6292
protein ubiquitination	1.3075E-4	26	65	4	6292
cellular metabolic process	1.3193E-4	26	3033	22	6292
macromolecule catabolic process	1.3818E-4	26	294	7	6292
regulation of cellular process	1.5749E-4	26	796	11	6292
DNA replication, synthesis of RNA primer	1.6296E-4	26	5	2	6292
regulation of biological process	2.1565E-4	26	824	11	6292
metabolic process	2.7748E-4	26	3157	22	6292
DNA-dependent DNA replication	3.2205E-4	26	82	4	6292
protein modification by small protein conjugation	3.8664E-4	26	86	4	6292
biological regulation	4.0291E-4	26	1213	13	6292
catabolic process	6.1607E-4	26	496	8	6292
RNA processing	6.6914E-4	26	380	7	6292
protein modification by small protein conjugation or removal	1.1232E-3	26	114	4	6292
cellular catabolic process	1.1315E-3	26	415	7	6292
cellular process	1.2541E-3	26	4426	25	6292
DNA replication	1.49E-3	26	123	4	6292
gene expression	2.726E-3	26	1283	12	6292
retrograde vesicle-mediated transport, Golgi to ER	5.0211E-3	26	26	2	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
3'-5'-exoribonuclease activity	2.0021E-12	26	23	7	6292
exoribonuclease activity, producing 5'-phosphomonoesters	5.3293E-12	26	26	7	6292
exoribonuclease activity	5.3293E-12	26	26	7	6292
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	4.2668E-11	26	34	7	6292
3'-5' exonuclease activity	5.3194E-11	26	35	7	6292
exonuclease activity	4.1121E-10	26	46	7	6292
nuclease activity	8.3292E-7	26	199	8	6292
ribonuclease activity	1.6358E-6	26	149	7	6292
DNA primase activity	1.6421E-5	26	2	2	6292
hydrolase activity, acting on ester bonds	4.5287E-5	26	341	8	6292
ubiquitin-protein ligase activity	7.8016E-5	26	57	4	6292
small conjugating protein ligase activity	1.0864E-4	26	62	4	6292
acid-amino acid ligase activity	1.8451E-4	26	71	4	6292
ligase activity, forming carbon-nitrogen bonds	5.4291E-4	26	94	4	6292
ligase activity	3.0825E-3	26	150	4	6292
catalytic activity	3.8748E-3	26	2150	16	6292
3-oxoacyl-[acyl-carrier-protein] synthase activity	4.1322E-3	26	1	1	6292
nucleotidyltransferase activity	4.6317E-3	26	168	4	6292
methionine adenosyltransferase activity	8.248E-3	26	2	1	6292
3-oxoacyl-[acyl-carrier-protein] reductase activity	8.248E-3	26	2	1	6292
hydrolase activity	8.2921E-3	26	911	9	6292
RNA polymerase activity	8.4934E-3	26	34	2	6292
DNA-directed RNA polymerase activity	8.4934E-3	26	34	2	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis