Protein Overview: POP2

General Information:
Name(s) found:	POP2 / YNR052C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6324380\|ref\|NP_014450.1\| RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation; Pop2p [Saccharomyces cerevisiae] [NCBI NR] gi\|51013035\|gb\|AAT92811.1\| YNR052C [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S63383 POP2 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1709720\|sp\|P39008.2\|POP2_YEAST RecName: Full=Poly(A) ribonuclease POP2; AltName: Full=CCR4-associated factor 1 [NCBI NR] gi\|1302568\|emb\|CAA96333.1\| POP2 [Saccharomyces cerevisiae] [NCBI NR] Poly(A) ribonuclease POP2 OS=Saccharomyces cerevisiae GN=POP2 PE=1 SV=2 [Swiss-Prot] POP2 Protein required for glucose derepression [mips] RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation [SGD] (P39008) POP2 protein (CCR4-associated factor 1) [4932.FASTACCERV.txt] Chr XIV from 720644-719343, reverse complement [hmr_yeast5_DM3-1_pombe.fasta] Chr XIV from 719343-720644, reverse complement [yeastorf3.fasta] POP2, Chr XIV from 719343-720644, reverse complement [yeast_orfs2] POP2 SGDID:S0005335, Chr XIV from 720646-719345, reverse complement, Verified ORF [yeastflysequest.fasta] POP2 SGDID:S0005335, Chr XIV from 720647-719346, reverse complement, Verified ORF [10112005cervSGD.fasta] Pop2p [Saccharomyces cerevisiae]gi\|51013035\|gb\|AAT92811.1\| YNR052C [Saccharomyces cerevisiae]gi\|1302568\|emb\|CAA96333.1\| POP2 [Saccharomyces cerevisiae]gi\|2132396\|pir\|\|S63383 POP2 protein - yeast (Saccharomyces cerevisiae)gi\|1709720\|sp\|P39008\|POP2_YEAS [nrdb_11152004_Chlamydomonas] POP2 SGDID:S000005335, Chr XIV from 720649-719348, reverse complement, Verified ORF, "RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YNR052C [Saccharomyces cerevisiae] [nr-271106-contam.fasta] RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation; Pop2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] POP2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein POP2 (CCR4-associated factor 1) [nr-271106-contam.fasta] POP2 SGDID:S000005335, Chr XIV from 720650-719349, reverse complement, Verified ORF, "RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation" [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta] [chemostatdb.fasta] Poly(A) ribonuclease POP2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=POP2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] POP2 SGDID:S000005335, Chr XIV from 720647-719346, Genome Release 64-1-1, reverse complement, Verified ORF, "RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation" [yeast-030211-contam.fasta] POP2 SGDID:S000005335, Chr XIV from 720647-719346, Genome Release 64-2-1, reverse complement, Verified ORF, "RNase of the DEDD superfamily; subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation" [20141208_orf_trans.fasta] YNR052C SGDID:S000005335, Chr XIV from 720647-719346, Genome Release 64-1-1, reverse complement, Verified ORF, "RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	433 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA] CCR4-NOT core complex [IPI]
Biological Process:	nuclear-transcribed mRNA poly(A) tail shortening [IDA ][IMP] regulation of transcription from RNA polymerase II promoter [IPI] RNA elongation from RNA polymerase II promoter [IMP]
Molecular Function:	3'-5'-exoribonuclease activity [IDA][IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSMNVQPRV LAVGGEQFFS QRQASEQHQQ QNMGPQVYSP KVNRARMFPQ GMPVNTINGS  60
   61 VNQEMNNAYL LKQKNEPLLT QQQQQQQQQQ QPFNIGTPVS VASLPPGLNV LQQQQQQQQQ 120
  121 QQQQQQGVGL NRPLASQLPK HLTNQSMPPI FLPPPNYLFV RDVWKSNLYS EFAVIRQLVS 180
  181 QYNHVSISTE FVGTLARPIG TFRSKVDYHY QTMRANVDFL NPIQLGLSLS DANGNKPDNG 240
  241 PSTWQFNFEF DPKKEIMSTE SLELLRKSGI NFEKHENLGI DVFEFSQLLM DSGLMMDDSV 300
  301 TWITYHAAYD LGFLINILMN DSMPNNKEDF EWWVHQYMPN FYDLNLVYKI IQEFKNPQLQ 360
  361 QSSQQQQQQQ YSLTTLADEL GLPRFSIFTT TGGQSLLMLL SFCQLSKLSM HKFPNGTDFA 420
  421 KYQGVIYGID GDQ

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CAF130 CAF40 CCR4 CDC39 POP2
View Details	(MIPS) Mewes HW, et al. (2004)		CAF16 CAF4 CCR4 CDC36 CDC39 DBF2 DHH1 DRS1 GAR1 IBA57 IFH1 MOB1 MOT2 NOP1 NOT3 NOT5 NPL3 NSR1 POP1 POP2 RAT1 RNT1 RRP3 SBP1 SNM1 SRD1 UTP10 UTP11 UTP13 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9 YME2
View Details	Krogan NJ, et al. (2006)		CAF40 CCR4 CDC39 POP2
View Details	Gavin AC, et al. (2006)		CAF40 CCR4 CDC39 POP2
View Details	Gavin AC, et al. (2002)		AHA1 ATP11 CAF130 CAF40 CCR4 CCT6 CDC36 CDC39 COP1 FAS2 GCN1 MOT2 NOT3 NOT5 PDC1 POL1 POL12 POP2 PRI1 PRI2 RVB2 SAM1 SEC27 TFC7 TFP1 YRA1
View Details	Ho Y, et al. (2002)		BUD14 CCR4 CDC36 CDC39 CMP2 CYS4 DOG1 GIS4 HSP104 KEL1 KEL2 KIN2 KRE6 PIL1 POP2 RNQ1 RVB1 STI1 TEF4 TFC4 UBA1 UBR1
View Details	Qiu et al. (2008)		CAF130 CAF16 CAF4 CAF40 CCR4 CDC36 CDC39 DBF2 DBP2 DHH1 DIS3 IBA57 MOB1 MOT2 NOT3 NOT5 POP2 SSN2 SUS1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	ROM1	POP2	2	Unpublished Fields Lab Data
View Screen	REG2	POP2	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	POP2	Huh WK, et al. (2003)
View Data	POP2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..154]	deduced	N/A	No confident structure predictions are available.
2	View Details	[155..433]	ORFEUS	7.35	Exonuclease I

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
ribonuclease activity	5.30591758406946	bayes_pls_golite062009
	3.73707272511921	bayes_pls_golite062009
exoribonuclease activity	3.71639182685131	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	3.59362615133405	bayes_pls_golite062009
3'-5'-exoribonuclease activity	3.1992647486402	bayes_pls_golite062009
nuclease activity	3.11657409772275	bayes_pls_golite062009
RNA binding	3.01997241125209	bayes_pls_golite062009
ribonuclease H activity	2.91966688044755	bayes_pls_golite062009
hydrolase activity	2.78602644579272	bayes_pls_golite062009
endonuclease activity	2.63074055051349	bayes_pls_golite062009
endoribonuclease activity	2.59247838057313	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	2.57498413015114	bayes_pls_golite062009
transcription regulator activity	2.20855917457806	bayes_pls_golite062009
nucleic acid binding	2.14285769817394	bayes_pls_golite062009
exonuclease activity	1.87925169250843	bayes_pls_golite062009
DNA binding	1.86594005896134	bayes_pls_golite062009
3'-5' exonuclease activity	1.44123900197846	bayes_pls_golite062009
transcription activator activity	1.43417601839369	bayes_pls_golite062009
binding	1.35497934205068	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.32513822925426	bayes_pls_golite062009
catalytic activity	1.25233849524628	bayes_pls_golite062009
transcription factor activity	1.17659544650821	bayes_pls_golite062009
mRNA binding	1.10473275263716	bayes_pls_golite062009
protein binding	1.08578027658199	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.71760273606768	bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters	0.708753843279937	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.615788727884275	bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.598360955770972	bayes_pls_golite062009
molecular transducer activity	0.515815362174888	bayes_pls_golite062009
signal transducer activity	0.515815362174888	bayes_pls_golite062009
deoxyribonuclease activity	0.24906263529692	bayes_pls_golite062009
DNA-directed DNA polymerase activity	0.09423425042945	bayes_pls_golite062009
DNA polymerase activity	0.0189279348688405	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.73

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2