YRC Public Data Repository - Protein Structure Prediction

Protein:	POP2
Organism:	Saccharomyces cerevisiae
Length:	433 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for POP2.

Description	E-value	Query Range	Subject Range
gi\|218465 - gi\|218465\|dbj\|BAA02246.1\| POP2 protein [Saccharomyces cerevisiae]	0.0	[1..433]	[1..433]
CNOT7_MOUSE - CCR4-NOT transcription complex subunit 7 OS=Mus musculus GN=Cnot7 PE=1 SV=1 CNOT7_BOVIN - CCR4-NOT transcription complex subunit 7 OS=Bos taurus GN=CNOT7 PE=2 SV=1 gi\|189442761, gi... - gi\|27671394\|ref\|XP_224894.1\| PREDICTED: similar to CCR4-NOT transcription complex subunit 7 (CCR4-as...	0.0	[147..429]	[1..262]
gi\|149742664, gi... - gi\|149742664\|ref\|XP_001488485.1\| PREDICTED: similar to CNOT7 protein isoform 1 [Equus caballus], gi\|... CCDS6000.2_1 - null CNOT7_CHICK - CCR4-NOT transcription complex subunit 7 OS=Gallus gallus GN=CNOT7 PE=2 SV=1 gi\|73979407 - gi\|73979407\|ref\|XP_540010.2\| PREDICTED: similar to CCR4-NOT transcription complex subunit 7 (CCR4-as... gi\|109085706, gi... - gi\|109085706\|ref\|XP_001095793.1\| PREDICTED: CCR4-NOT transcription complex, subunit 7 isoform 7 [Mac... gi\|114618908, gi... - gi\|114618908\|ref\|XP_001141414.1\| PREDICTED: hypothetical protein LOC464006 isoform 2 [Pan troglodyte... ENSCJAT00000022924 - null tr\|M3VV22\|M3VV22... - CCR4-NOT transcription complex subunit 7 OS=Felis catus GN=CNOT7 PE=4 SV=1 gi\|542149998\|ref... - PREDICTED: CCR4-NOT transcription complex subunit 7 [Zonotrichia albicollis] gi\|224049852 - gi\|224049852\|ref\|XP_002194151.1\| PREDICTED: CCR4-NOT transcription complex, subunit 7 [Taeniopygia g... CNOT7 - CCR4-NOT transcription complex, subunit 7 tr\|G3GZC4\|G3GZC4... - CCR4-NOT transcription complex subunit 7 OS=Cricetulus griseus GN=H671_1g2546 PE=4 SV=1 tr\|G1T7P8\|G1T7P8... - pep:novel scaffold:oryCun2:GL018717:2257628:2258485:-1 gene:ENSOCUG00000023781 transcript:ENSOCUT000...	0.0	[147..429]	[1..262]
Pop2-PA - The gene Pop2 is referred to in FlyBase by the symbol Dmel\Pop2 (CG5684, FBgn0036239). It is a prote... gi\|220954902, gi... - gi\|220954902\|gb\|ACL89994.1\| Pop2-PA [synthetic construct], gi\|220945074\|gb\|ACL85080.1\| Pop2-PA [synt...	0.0	[148..429]	[13..275]

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Predicted Domain #1

Region A:
Residues: [1-154]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSMNVQPRV LAVGGEQFFS QRQASEQHQQ QNMGPQVYSP KVNRARMFPQ GMPVNTINGS  60
   61 VNQEMNNAYL LKQKNEPLLT QQQQQQQQQQ QPFNIGTPVS VASLPPGLNV LQQQQQQQQQ 120
  121 QQQQQQGVGL NRPLASQLPK HLTNQSMPPI FLPP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [155-433]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNYLFVRDVW KSNLYSEFAV IRQLVSQYNH VSISTEFVGT LARPIGTFRS KVDYHYQTMR  60
   61 ANVDFLNPIQ LGLSLSDANG NKPDNGPSTW QFNFEFDPKK EIMSTESLEL LRKSGINFEK 120
  121 HENLGIDVFE FSQLLMDSGL MMDDSVTWIT YHAAYDLGFL INILMNDSMP NNKEDFEWWV 180
  181 HQYMPNFYDL NLVYKIIQEF KNPQLQQSSQ QQQQQQYSLT TLADELGLPR FSIFTTTGGQ 240
  241 SLLMLLSFCQ LSKLSMHKFP NGTDFAKYQG VIYGIDGDQ

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.35
Match:	1fxxA
Description:	Exonuclease I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ribonuclease activity	5.30591758406946	bayes_pls_golite062009
	3.73707272511921	bayes_pls_golite062009
exoribonuclease activity	3.71639182685131	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	3.59362615133405	bayes_pls_golite062009
3'-5'-exoribonuclease activity	3.1992647486402	bayes_pls_golite062009
nuclease activity	3.11657409772275	bayes_pls_golite062009
RNA binding	3.01997241125209	bayes_pls_golite062009
ribonuclease H activity	2.91966688044755	bayes_pls_golite062009
hydrolase activity	2.78602644579272	bayes_pls_golite062009
endonuclease activity	2.63074055051349	bayes_pls_golite062009
endoribonuclease activity	2.59247838057313	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	2.57498413015114	bayes_pls_golite062009
transcription regulator activity	2.20855917457806	bayes_pls_golite062009
nucleic acid binding	2.14285769817394	bayes_pls_golite062009
exonuclease activity	1.87925169250843	bayes_pls_golite062009
DNA binding	1.86594005896134	bayes_pls_golite062009
3'-5' exonuclease activity	1.44123900197846	bayes_pls_golite062009
transcription activator activity	1.43417601839369	bayes_pls_golite062009
binding	1.35497934205068	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.32513822925426	bayes_pls_golite062009
catalytic activity	1.25233849524628	bayes_pls_golite062009
transcription factor activity	1.17659544650821	bayes_pls_golite062009
mRNA binding	1.10473275263716	bayes_pls_golite062009
protein binding	1.08578027658199	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.71760273606768	bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters	0.708753843279937	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.615788727884275	bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.598360955770972	bayes_pls_golite062009
molecular transducer activity	0.515815362174888	bayes_pls_golite062009
signal transducer activity	0.515815362174888	bayes_pls_golite062009
deoxyribonuclease activity	0.24906263529692	bayes_pls_golite062009
DNA-directed DNA polymerase activity	0.09423425042945	bayes_pls_golite062009
DNA polymerase activity	0.0189279348688405	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: