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Protein Overview: YKU80

General Information:
Name(s) found: YKU80 / YMR106C [SGD]
Description(s) found:
Found 33 descriptions.
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  • Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 629 amino acids

    Gene Ontology:
    Cellular Component: nuclear chromatin [TASLink to PubMed article]
    nuclear telomeric heterochromatin [TASLink to PubMed article]
    Biological Process: double-strand break repair via homologous recombination [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed articleLink to PubMed article]
    chromatin assembly or disassembly [IDALink to PubMed article]
    chromatin silencing [IDALink to PubMed article][IMPLink to PubMed article]
    double-strand break repair via nonhomologous end joining [IDALink to PubMed article]
    donor selection [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    RNA binding [IDALink to PubMed article]
    damaged DNA binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSESTTFIV DVSPSMMKNN NVSKSMAYLE YTLLNKSKKS RKTDWISCYL ANCPVSENSQ  60
   61 EIPNVFQIQS FLAPVTTTAT IGFIKRLKQY CDQHSHDSSN EGLQSMIQCL LVVSLDIKQQ 120
  121 FQARKILKQI VVFTDNLDDL DITDEEIDLL TEELSTRIIL IDCGKDTQEE RKKSNWLKLV 180
  181 EAIPNSRIYN MNELLVEITS PATSVVKPVR VFSGELRLGA DILSTQTSNP SGSMQDENCL 240
  241 CIKVEAFPAT KAVSGLNRKT AVEVEDSQKK ERYVGVKSII EYEIHNEGNK KNVSEDDQSG 300
  301 SSYIPVTISK DSVTKAYRYG ADYVVLPSVL VDQTVYESFP GLDLRGFLNR EALPRYFLTS 360
  361 ESSFITADTR LGCQSDLMAF SALVDVMLEN RKIAVARYVS KKDSEVNMCA LCPVLIEHSN 420
  421 INSEKKFVKS LTLCRLPFAE DERVTDFPKL LDRTTTSGVP LKKETDGHQI DELMEQFVDS 480
  481 MDTDELPEIP LGNYYQPIGE VTTDTTLPLP SLNKDQEENK KDPLRIPTVF VYRQQQVLLE 540
  541 WIHQLMINDS REFEIPELPD SLKNKISPYT HKKFDSTKLV EVLGIKKVDK LKLDSELKTE 600
  601 LEREKIPDLE TLLKRGEQHS RGSPNNSNN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) YKU70 YKU80
    View Details (MIPS) Mewes HW, et al. (2004) YKU70 YKU80
    View Details Krogan NJ, et al. (2006) FMP48 MUC1 YKU70 YKU80
    View Details Gavin AC, et al. (2006) YKU70 YKU80
    View Details Gavin AC, et al. (2002) YKU70 YKU80
    View Details Ho Y, et al. (2002) ACC1 ADR1 APT1 ARO1 ATP3 AVO1 CCT3 CCT5 CLU1 COP1 CPA2 DEF1 DHH1 DPB2 DSS1 ECM10 FOL2 FUN12 GAL7 GPH1 IDH1 ILV2 LSC1 LST8 LYS12 MET16 MKK2 MTC5 NOG2 NPA3 OYE2 PDX1 PHO85 PHO86 POR1 PRE1 PST2 PUF3 PUP3 RPN12 RRP3 SIP1 SIS1 SLC1 SLX1 SOD2 SRP54 STI1 TEM1 TFC7 TMA29 TPS1 TSA2 VMA8 YBT1 YER077C YGR266W YHR033W YKR051W YKU80 YLR271W YML020W YPR003C
    View Details Qiu et al. (2008) PCC1 TBF1 YKU80

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RGD2 YKU80 2 Unpublished Fields Lab Data
    View Screen YKU80 ECO1 1 Unpublished Fields Lab Data
    View Screen YKU80 SPT21 1 Unpublished Fields Lab Data
    View Screen YKU80 YGL079W 1 Unpublished Fields Lab Data
    View Screen YKU80 EFR3 1 Unpublished Fields Lab Data
    View Screen YKU80 FRA2 1 Unpublished Fields Lab Data
    View Screen YKU80 TAF9 1 Unpublished Fields Lab Data
    View Screen YKU80 HAP2 1 Unpublished Fields Lab Data
    View Screen YKU80 YMR245W 1 Unpublished Fields Lab Data
    View Screen YKU80 PPT1 1 Unpublished Fields Lab Data
    View Screen YKU80 URE2 1 Unpublished Fields Lab Data
    View Screen YKU80 HUA1 1 Unpublished Fields Lab Data
    View Screen YKU80 YOR302W 1 Unpublished Fields Lab Data
    View Screen YKU80 BCY1 1 Unpublished Fields Lab Data
    View Screen YKU80 TYE7 1 Unpublished Fields Lab Data
    View Screen YKU80 YJL160C 1 Unpublished Fields Lab Data
    View Screen YKU80 YPR147C 1 Unpublished Fields Lab Data
    View Screen YKU80 BFA1 1 Unpublished Fields Lab Data
    View Screen NAF1 YKU80 1 Hazbun TR, et al. (2003)
    View Screen YKU80 PTK2 1 Unpublished Fields Lab Data
    View Screen YKU80 AUR1 1 Unpublished Fields Lab Data
    View Screen YKU80 TAE1 1 Unpublished Fields Lab Data
    View Screen YKU80 TPO1 1 Unpublished Fields Lab Data
    View Screen YKU80 PTC1 1 Unpublished Fields Lab Data
    View Screen YKU80 EST1 1 Unpublished Fields Lab Data
    View Screen YKU80 SIR2 1 Unpublished Fields Lab Data
    View Screen YKU80 YML053C 1 Unpublished Fields Lab Data
    View Screen YKU80 CDC36 1 Unpublished Fields Lab Data
    View Screen YKU80 VBA1 1 Unpublished Fields Lab Data
    View Screen YKU80 TSA2 1 Unpublished Fields Lab Data
    View Screen YKU80 YIM1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YKU80 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..244]
    [269..288]
    [481..513]    		 PSI-BLAST 158.0 DNA binding C-terminal domain of ku70; Ku70 subunit
    2 View Details [245..268]
    [289..445]    		 PSI-BLAST 158.0 DNA binding C-terminal domain of ku70; Ku70 subunit
    3 View Details [446..480]
    [514..629]    		 PSI-BLAST 158.0 DNA binding C-terminal domain of ku70; Ku70 subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • double-stranded telomeric DNA binding
    		•  8.64621483095491 bayes_pls_golite062009
  • DNA-dependent protein kinase activity
    		•  7.33495559751688 bayes_pls_golite062009
  • telomeric DNA binding
    		•  5.16364366157397 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.05720838352689 bayes_pls_golite062009
  • binding
    		•  2.75824485094584 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.08531850924748 bayes_pls_golite062009
  • promoter binding
    		•  1.97164983798318 bayes_pls_golite062009
  • DNA binding
    		•  1.91667917801679 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.69798374416156 bayes_pls_golite062009
  • transcription activator activity
    		•  1.54159704189366 bayes_pls_golite062009
  • protein binding
    		•  1.53311876872122 bayes_pls_golite062009
  • transcription factor activity
    		•  1.37299910766941 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.985753648509262 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.814975395718076 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.720743494912414 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.702777559747981 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.506640285146188 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.45109468643752 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.450760554291027 bayes_pls_golite062009
  • structural molecule activity
    		•  0.375125487765613 bayes_pls_golite062009
  • transporter activity
    		•  0.371057816653329 bayes_pls_golite062009
  • protein complex binding
    		•  0.31789779419928 bayes_pls_golite062009
  • transcription factor binding
    		•  0.184852480703492 bayes_pls_golite062009
  • protein C-terminus binding
    		•  0.15516806759612 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle