Protein Overview: YML6

General Information:
Name(s) found:	YML6 / YML025C [SGD]
Description(s) found: Found 26 descriptions. SHOW ALL	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins [SGD]
Organism:	Saccharomyces cerevisiae
Length:	286 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial large ribosomal subunit [IDA]
Biological Process:	ribosomal large subunit assembly [ISS] translation [IDA]
Molecular Function:	structural constituent of ribosome [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIKRNLVKT LQSIRYQATT ATAHAESTLN PLPNAAIPPK YALVTVRSFP SLEPLTFVPV  60
   61 PTSTVAAPLR RDILWRAVVY ENDNRRVGAS NPPGRSENGF SRRKLMPQKG SGRARVGDAN 120
  121 SPTRHNGGRA LARTAPNDYT TELPSKVYSM AFNNALSHQY KSGKLFVIGG EKVDLISPTP 180
  181 ELDLNRLDLV NTNTVEGKEI FEGEVIFRKF LEEFQLKGKR LLFITDKTRE GLIKSSDPYK 240
  241 QKVDVIQKEL VEVNDILRAQ AVFIELEALE YLAMAHQKEI LHSVSN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		IMG1 IMG2 MHR1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL13 MRPL15 MRPL16 MRPL17 MRPL20 MRPL23 MRPL24 MRPL28 MRPL3 MRPL35 MRPL36 MRPL4 MRPL40 MRPL51 MRPL7 MRPL8 MRPL9 RTC6 YML6
View Details	(MIPS) Mewes HW, et al. (2004)		IMG1 IMG2 MNP1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL11 MRPL13 MRPL15 MRPL16 MRPL17 MRPL19 MRPL20 MRPL22 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL31 MRPL32 MRPL33 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL44 MRPL49 MRPL50 MRPL51 MRPL6 MRPL7 MRPL8 MRPL9 RML2 RTC6 YDR115W YML6
View Details	Krogan NJ, et al. (2006)		MRP49 MRPL13 YML6
View Details	Gavin AC, et al. (2006)		IMG1 MHR1 MRP49 MRPL35 MRPL8 MRPL9 YML6
View Details	Gavin AC, et al. (2002)		AAR2 ATG26 BEM2 BRR1 BUD3 BUD31 CDC33 CEF1 CLF1 COP1 CSN12 CUS1 CWC2 CWC22 CWC23 CYR1 DHH1 DIB1 ECM2 GCN2 HRR25 HSH155 HTA1 IMG1 IMG2 IML1 LEA1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 MHR1 MRH4 MRM1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL13 MRPL15 MRPL16 MRPL17 MRPL19 MRPL20 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL35 MRPL36 MRPL38 MRPL39 MRPL4 MRPL44 MRPL51 MRPL6 MRPL7 MRPL8 MRPS5 MSL1 MUD1 NIC96 NSP1 NUG1 NUP116 NUP159 NUP82 PAT1 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 RET2 ROM2 RSE1 RTC6 RVB2 SEC1 SEC26 SEC27 SIN4 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNF2 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 STO1 SWI3 SYF1 SYP1 TAF5 TOS4 UTP20 UTP21 YDR115W YML6
View Details	Qiu et al. (2008)		AAC3 AST2 BUD20 ECM12 FYV12 IMG1 IMG2 MHR1 MNP1 MRM2 MRP1 MRP10 MRP13 MRP17 MRP20 MRP21 MRP4 MRP49 MRP51 MRP7 MRPL1 MRPL10 MRPL11 MRPL13 MRPL15 MRPL16 MRPL17 MRPL19 MRPL20 MRPL22 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL31 MRPL32 MRPL33 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL44 MRPL49 MRPL50 MRPL51 MRPL6 MRPL7 MRPL8 MRPL9 MRPS12 MRPS16 MRPS17 MRPS18 MRPS28 MRPS35 MRPS5 MRPS8 MRPS9 NAM9 PET123 RML2 RPL10 RPL11A RPL11B RPL12B, RPL12A RPL13A RPL14A RPL14B RPL15A RPL16A RPL16B RPL17A RPL17B RPL18A, RPL18B RPL19B, RPL19A RPL1A, RPL1B RPL20A RPL20B RPL21A RPL21B RPL22B RPL23B, RPL23A RPL25 RPL26A RPL26B RPL27B RPL28 RPL29 RPL2A, RPL2B RPL3 RPL30 RPL31A RPL31B RPL33A RPL33B RPL34A RPL35A, RPL35B RPL36A RPL36B RPL37A RPL37B RPL38 RPL39 RPL40B, RPL40A RPL41A, RPL41B RPL42B, RPL42A RPL43B, RPL43A RPL5 RPL6A RPL6B RPL8A RPL9A RPL9B RPP0 RPP1B RPP2A RPS0A RPS0B RPS10A RPS11A, RPS11B RPS12 RPS13 RPS14B RPS15 RPS16B, RPS16A RPS17A RPS19B RPS2 RPS20 RPS21A RPS21B RPS22A RPS23B, RPS23A RPS24A, RPS24B RPS25B RPS26A RPS26B RPS27A RPS27B RPS29A RPS29B RPS30B, RPS30A RPS31 RPS7B RPS8B, RPS8A RPS9B RSM10 RSM18 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM7 RTC6 RXT3 SFT1 SWS2 TIM21 VAR1 YDR115W YLR326W YML6 YMR31 YOR292C

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	TEL1	YML6	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	YML6	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..286]	PSI-BLAST	108.440336	Ribosomal protein L4

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
structural constituent of ribosome	9.46714384821627	bayes_pls_golite062009
structural molecule activity	8.89019844429202	bayes_pls_golite062009
binding	1.20549540301208	bayes_pls_golite062009
protein binding	0.69049990447008	bayes_pls_golite062009
nucleic acid binding	0.570954007051262	bayes_pls_golite062009
RNA binding	0.514741551458219	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.93

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2