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Protein Overview: MRM2

General Information:
Name(s) found: MRM2 / YGL136C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 320 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    Biological Process: rRNA methylation [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    Molecular Function: rRNA (uridine-2'-O-)-methyltransferase activity [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MILVYNRIRS IISSSLGRIH VRYNSNSQNR WLNRQLKDPY TKEAKVQNLR SRAAFKLMQI  60
   61 DDKYRLFSKN RTDQRILDLG YAPGAWSQVA RQRSSPNSMI LGVDILPCEP PHGVNSIQAN 120
  121 ILAKRTHDLI RLFFSKHFQL NRHDDLHKDH GYFQNMLEEE LTHVKDTELY REIFTSDDIY 180
  181 ETPNTNSTLI EREKFPVDVI ISDMYEPWPQ TTGFWNNITN QAYFRMANTS GVSIRDHYQS 240
  241 IDLCDAALVT AIDLLRPLGS FVCKLYTGEE ENLFKKRMQA VFTNVHKFKP DASRDESKET 300
  301 YYIGLKKKRN VDKLDVFSNS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) MRM2 RPL39 RTA1 YML6

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..226] PSI-BLAST 110.201249 RNA methyltransferase FtsJ
    2 View Details [227..320] ORFEUS 13.02 RNA methyltransferase FtsJ


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle