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Protein Overview: CFT2

General Information:
Name(s) found: CFT2 / YLR115W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 859 amino acids

    Gene Ontology:
    Cellular Component: mRNA cleavage and polyadenylation specificity factor complex [IPILink to PubMed articleLink to PubMed article]
    mRNA cleavage factor complex [IPILink to PubMed article]
    Biological Process: mRNA polyadenylation [IDALink to PubMed article][TASLink to PubMed article]
    mRNA cleavage [IDALink to PubMed article][TASLink to PubMed article]
    Molecular Function: RNA binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTYKYNCCDD GSGTTVGSVV RFDNVTLLID PGWNPSKVSY EQCIKYWEKV IPEIDVIILS  60
   61 QPTIECLGAH SLLYYNFTSH FISRIQVYAT LPVINLGRVS TIDSYASAGV IGPYDTNKLD 120
  121 LEDIEISFDH IVPLKYSQLV DLRSRYDGLT LLAYNAGVCP GGSIWCISTY SEKLVYAKRW 180
  181 NHTRDNILNA ASILDATGKP LSTLMRPSAI ITTLDRFGSS QPFKKRSKIF KDTLKKGLSS 240
  241 DGSVIIPVDM SGKFLDLFTQ VHELLFESTK INAHTQVPVL ILSYARGRTL TYAKSMLEWL 300
  301 SPSLLKTWEN RNNTSPFEIG SRIKIIAPNE LSKYPGSKIC FVSEVGALIN EVIIKVGNSE 360
  361 KTTLILTKPS FECASSLDKI LEIVEQDERN WKTFPEDGKS FLCDNYISID TIKEEPLSKE 420
  421 ETEAFKVQLK EKKRDRNKKI LLVKRESKKL ANGNAIIDDT NGERAMRNQD ILVENVNGVP 480
  481 PIDHIMGGDE DDDEEEENDN LLNLLKDNSE KSAAKKNTEV PVDIIIQPSA ASKHKMFPFN 540
  541 PAKIKKDDYG TVVDFTMFLP DDSDNVNQNS RKRPLKDGAK TTSPVNEEDN KNEEEDGYNM 600
  601 SDPISKRSKH RASRYSGFSG TGEAENFDNL DYLKIDKTLS KRTISTVNVQ LKCSVVILNL 660
  661 QSLVDQRSAS IIWPSLKSRK IVLSAPKQIQ NEEITAKLIK KNIEVVNMPL NKIVEFSTTI 720
  721 KTLDISIDSN LDNLLKWQRI SDSYTVATVV GRLVKESLPQ VNNHQKTASR SKLVLKPLHG 780
  781 SSRSHKTGAL SIGDVRLAQL KKLLTEKNYI AEFKGEGTLV INEKVAVRKI NDAETIIDGT 840
  841 PSELFDTVKK LVTDMLAKI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CFT1 CFT2 FIP1 GLC7 MPE1 PAP1 PCF11 PFS2 PTA1 PTI1 REF2 RNA14 SSU72 SWD2 YSH1 YTH1
    View Details (MIPS) Mewes HW, et al. (2004) CFT1 CFT2 PTA1 YSH1
    View Details Krogan NJ, et al. (2006) AIM1 CFT1 CFT2 ECM21 FIP1 GIP4 MPE1 PAP1 PFS2 PTA1 PTI1 REF2 SSU72 SWD2 SYC1 YBL010C YLR358C YSH1 YTH1
    View Details Gavin AC, et al. (2006) CFT1 CFT2 FIP1 MPE1 PAP1 PFS2 PTA1 YSH1 YTH1
    View Details Gavin AC, et al. (2002) ACT1 ADE4 AIM31 BFR2 BMS1 BUD21 CBF5 CFT1 CFT2 CKA1 CLP1 DBP8 DIP2 ECM16 ECM29 EMG1 ENO2 ENP1 ENP2 ERO1 ESF1 ESF2 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HSL1 HTA1 HTA2 IMP3 IMP4 KRE33 KRR1 MPE1 MPP10 MVD1 NAN1 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 PAP1 PCF11 PFK1 PFS2 PRE6 PRE9 PRP43 PTA1 PTI1 PWP2 REF2 RML2 RNA14 RNA15 ROK1 RPP2B RRP9 RSA3 RTG2 SCL1 SEC13 SEC21 SEC31 SOF1 SRO9 SSA3 SSU72 SYC1 TAF6 TIF1, TIF2 TIF4632 TYE7 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 VID24 VMR1 VPS53 YCL046W YSH1 YTH1
    View Details Qiu et al. (2008) CFT1 CFT2 CLP1 FIP1 HRP1 PAP1 PFS2 PTI1 REF2 RNA14 RNA15 YSH1 YTH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPO1 CFT2 1 Unpublished Fields Lab Data
    View Screen ZIM17 CFT2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CFT2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..273] PSI-BLAST 10.69897 Rubredoxin oxygen:oxidoreductase (ROO), C-terminal domain; Rubredoxin oxygen:oxidoreductase (ROO), N-terminal domain
    2 View Details [274..481] MSA 1.17196 View MSA. No confident structure predictions are available.
    3 View Details [482..859] MSA 1.05888 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.97803450114143 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.66507162669272 bayes_pls_golite062009
  • RNA binding
    		•  1.48455378212673 bayes_pls_golite062009
  • catalytic activity
    		•  0.941400907161877 bayes_pls_golite062009
  • protein binding
    		•  0.380466845099285 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle