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Protein Overview: PRP19

General Information:
Name(s) found: PRP19 / YLL036C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 503 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    spliceosomal complex [IDALink to PubMed articleLink to PubMed article][IGILink to PubMed article]
    Biological Process: nuclear mRNA splicing, via spliceosome [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    ubiquitin-dependent protein catabolic process [IPILink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IDA][IEA][IMP]
    first spliceosomal transesterification activity [IC]
    RNA binding [RCA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLCAISGKVP RRPVLSPKSR TIFEKSLLEQ YVKDTGNDPI TNEPLSIEEI VEIVPSAQQA  60
   61 SLTESTNSAT LKANYSIPNL LTSLQNEWDA IMLENFKLRS TLDSLTKKLS TVMYERDAAK 120
  121 LVAAQLLMEK NEDSKDLPKS SQQAVAITRE EFLQGLLQSS RDFVARGKLK APKWPILKNL 180
  181 ELLQAQNYSR NIKTFPYKEL NKSMYYDKWV CMCRCEDGAL HFTQLKDSKT ITTITTPNPR 240
  241 TGGEHPAIIS RGPCNRLLLL YPGNQITILD SKTNKVLREI EVDSANEIIY MYGHNEVNTE 300
  301 YFIWADNRGT IGFQSYEDDS QYIVHSAKSD VEYSSGVLHK DSLLLALYSP DGILDVYNLS 360
  361 SPDQASSRFP VDEEAKIKEV KFADNGYWMV VECDQTVVCF DLRKDVGTLA YPTYTIPEFK 420
  421 TGTVTYDIDD SGKNMIAYSN ESNSLTIYKF DKKTKNWTKD EESALCLQSD TADFTDMDVV 480
  481 CGDGGIAAIL KTNDSFNIVA LTP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRR2 BUD31 CDC40 CEF1 CLF1 CUS1 CWC2 CWC22 CWC23 DIB1 ECM2 HSH155 ISY1 LEA1 PRP19 PRP21 PRP3 PRP31 PRP4 PRP43 PRP45 PRP46 PRP6 PRP8 PRP9 RSE1 SMB1 SMD3 SNT309 SNU114 SNU71 SPP382 STO1 SYF1
    View Details Hazbun TR, et al. (2003) BRR2 CDC40 CEF1 CLF1 COR1 CWC2 CWC22 CWC23 CWC25 ECM2 ISY1 LEA1 NTR2 PRP19 PRP43 PRP45 PRP46 PRP8 SMB1 SMD1 SMD3 SMX3 SNT309 SNU114 SPP382 SYF1 SYF2 YJU2 YLR132C
    View Details (MIPS) Mewes HW, et al. (2004) PRP19 PRP21 SNT309
    View Details Krogan NJ, et al. (2006) CWC22 MSS18 PRP19 PRP46 YLR132C
    View Details Gavin AC, et al. (2006) CDC40 CEF1 CLF1 CWC2 CWC22 ECM2 PRP19 PRP45 PRP46 SYF1
    View Details Gavin AC, et al. (2002) AAR2 BRR1 BUD31 CBC2 CDC33 CDC40 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DHH1 DIB1 ECM2 GCN2 HRT1 HSH155 HSH49 HTA1 IMG1 ISY1 LEA1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 NAM8 NPL3 PAT1 PRP11 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 STO1 SYF1 TIF4631 TIF4632 TOS4 UTP21 YEF3 YML6
    View Details Ho Y, et al. (2002) CCT5 CEF1 CLF1 COR1 DED81 DUN1 EGD1 GCD11 NAP1 NMD3 PRP19 QCR2 SNT309 SOD1 TCP1 TIF1, TIF2 YJU2 YNK1
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 CBC2 CDC40 CEF1 CLF1 CUS1 CWC15 CWC2 CWC22 CWC23 CWC25 DHR2 DIB1 HSH155 ISY1 LEA1 LSM2 LSM3 LSM4 LSM5 LSM8 LUC7 MAK5 MUD1 MUD2 NAM8 NTC20 PRP11 PRP16 PRP18 PRP19 PRP2 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SUB2 SYF1 SYF2 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run YLR132C No Comments Hazbun TR, et al. (2003)
    View Run CWC2 No Comments Hazbun TR, et al. (2003)
    View Run SPP382 No Comments Hazbun TR, et al. (2003)
    View Run YLR132C No Comments Hazbun TR, et al. (2003)
    View Run SPP382 No Comments Hazbun TR, et al. (2003)
    View Run NSE3 No Comments Hazbun TR, et al. (2003)
    View Run CWC25 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CWC2 PRP19 2 Hazbun TR, et al. (2003)
    View Screen YHR122W PRP19 1 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PRP19 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..124] PSI-BLAST 2.69897 STAT-1, coiled coil domain; STAT-1, DNA-binding domain; STAT-1
    2 View Details [125..503] PSI-BLAST 77.39794 beta1-subunit of the signal-transducing G protein heterotrimer

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
    		• 4.77196423114965 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  3.95853381924066 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  3.91255887330293 bayes_pls_golite062009
  • RNA binding
    		•  3.04658201081989 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  2.94837447933806 bayes_pls_golite062009
  • binding
    		•  2.78710909602478 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.32056863527247 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.91926431269551 bayes_pls_golite062009
  • DNA binding
    		•  1.67694054164995 bayes_pls_golite062009
  • protein binding
    		•  1.5975811408548 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  1.43156142066182 bayes_pls_golite062009
  • ligase activity
    		•  1.36029325773279 bayes_pls_golite062009
  • transcription factor binding
    		•  1.04179360284548 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.97326424822508 bayes_pls_golite062009
  • transcription factor activity
    		•  0.942440775656356 bayes_pls_golite062009
  • hydrolase activity
    		•  0.39313698408945 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.251823232412941 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.120138679619734 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle