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Protein Overview: KGD1

General Information:
Name(s) found: KGD1 / YIL125W [SGD]
Description(s) found:
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  • gi|730221|sp|P20967.2|ODO1_YEAST RecName: Full=2-oxoglutarate dehydrogenase E1 component, mitochondrial; AltName: Full=Alpha-ketoglutarate dehydrogenase; Flags: Precursor [NCBI NR]
  • gi|6322066|ref|NP_012141.1| Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA; Kgd1p [Sacch [NCBI NR]
  • gi|599992|emb|CAA86867.1| 2-oxoglutarate dehydrogenase E1 component [Saccharomyces cerevisiae] [NCBI NR]
  • pir||DEBY oxoglutarate dehydrogenase (lipoamide) (EC 1.2.4.2) precursor - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • 2-oxoglutarate dehydrogenase, mitochondrial OS=Saccharomyces cerevisiae GN=KGD1 PE=1 SV=2 [Swiss-Prot]
  • KGD1 2-oxoglutarate dehydrogenase complex E1 component [mips]
  • Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA [SGD]
  • KGD1, Chr IX from 122689-125733 [yeast_orfs2]
  • Chr IX from 122689-125733 [yeastorf3.fasta]
  • (P20967) 2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase) [4932.FASTACCERV.txt]
  • KGD1 SGDID:S0001387, Chr IX from 122689-125733, Verified ORF [yeastflysequest.fasta]
  • Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA [Saccharomyces cerevisiae]gi|599992|emb| [nrdb_11152004_Chlamydomonas]
  • KGD1 SGDID:S000001387, Chr IX from 122689-125733, Verified ORF, "Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutara [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • 2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor (Alpha-ketoglutarate dehydrogenase) [nr-271106-contam.fasta]
  • Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA; Kgd1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • 2-oxoglutarate dehydrogenase E1 component [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • KGD1 SGDID:S000001387, Chr IX from 122689-125733, Verified ORF, "Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • 2-oxoglutarate dehydrogenase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KGD1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • KGD1 SGDID:S000001387, Chr IX from 122689-125733, Genome Release 64-1-1, Verified ORF, "Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA" [yeast-030211-contam.fasta]
  • KGD1 SGDID:S000001387, Chr IX from 122689-125733, Genome Release 64-2-1, Verified ORF, "Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex; catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA" [20141208_orf_trans.fasta]
  • YIL125W SGDID:S000001387, Chr IX from 122689-125733, Genome Release 64-1-1, Verified ORF, "Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1014 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [TASLink to PubMed article]
    mitochondrial oxoglutarate dehydrogenase complex [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    mitochondrial nucleoid [IDALink to PubMed articleLink to PubMed article]
    Biological Process: tricarboxylic acid cycle [TASLink to PubMed article]
    2-oxoglutarate metabolic process [TASLink to PubMed article]
    Molecular Function: oxoglutarate dehydrogenase (succinyl-transferring) activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRFVSSQTC RYSSRGLLKT SLLKNASTVK IVGRGLATTG TDNFLSTSNA TYIDEMYQAW  60
   61 QKDPSSVHVS WDAYFKNMSN PKIPATKAFQ APPSISNFPQ GTEAAPLGTA MTGSVDENVS 120
  121 IHLKVQLLCR AYQVRGHLKA HIDPLGISFG SNKNNPVPPE LTLDYYGFSK HDLDKEINLG 180
  181 PGILPRFARD GKSKMSLKEI VDHLEKLYCS SYGVQYTHIP SKQKCDWLRE RIEIPEPYQY 240
  241 TVDQKRQILD RLTWATSFES FLSTKFPNDK RFGLEGLESV VPGIKTLVDR SVELGVEDIV 300
  301 LGMAHRGRLN VLSNVVRKPN ESIFSEFKGS SARDDIEGSG DVKYHLGMNY QRPTTSGKYV 360
  361 NLSLVANPSH LESQDPVVLG RTRALLHAKN DLKEKTKALG VLLHGDAAFA GQGVVYETMG 420
  421 FLTLPEYSTG GTIHVITNNQ IGFTTDPRFA RSTPYPSDLA KAIDAPIFHV NANDVEAVTF 480
  481 IFNLAAEWRH KFHTDAIIDV VGWRKHGHNE TDQPSFTQPL MYKKIAKQKS VIDVYTEKLI 540
  541 SEGTFSKKDI DEHKKWVWNL FEDAFEKAKD YVPSQREWLT AAWEGFKSPK ELATEILPHE 600
  601 PTNVPESTLK ELGKVLSSWP EGFEVHKNLK RILKNRGKSI ETGEGIDWAT GEALAFGTLV 660
  661 LDGQNVRVSG EDVERGTFSQ RHAVLHDQQS EAIYTPLSTL NNEKADFTIA NSSLSEYGVM 720
  721 GFEYGYSLTS PDYLVMWEAQ FGDFANTAQV IIDQFIAGGE QKWKQRSGLV LSLPHGYDGQ 780
  781 GPEHSSGRLE RFLQLANEDP RYFPSEEKLQ RQHQDCNFQV VYPTTPANLF HILRRQQHRQ 840
  841 FRKPLALFFS KQLLRHPLAR SSLSEFTEGG FQWIIEDIEH GKSIGTKEET KRLVLLSGQV 900
  901 YTALHKRRES LGDKTTAFLK IEQLHPFPFA QLRDSLNSYP NLEEIVWCQE EPLNMGSWAY 960
  961 TEPRLHTTLK ETDKYKDFKV RYCGRNPSGA VAAGSKSLHL AEEDAFLKDV FQQS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) KGD1 KGD2 LPD1 YMR31
    View Details (MIPS) Mewes HW, et al. (2004) KGD1 KGD2 LPD1
    View Details Krogan NJ, et al. (2006) KGD1 KGD2 STE5
    View Details Gavin AC, et al. (2006) KGD1 KGD2 YMR31
    View Details Gavin AC, et al. (2002) CLU1 KAP123 KGD1 KGD2 LEA1 LPD1 SAM1 YMR31
    View Details Ho Y, et al. (2002) ACO1 ATG12 CAP1 CAP2 CAR1 CAR2 CDC15 CDC33 CDC60 CIC1 COF1 COR1 CPA2 CPR1 CPR3 CRM1 CYS4 DBP8 DEF1 DNL4 DUG2 DUT1 EMP24 FAA1 FET3 GDE1 GND1 GPH1 GSP1 GSP2 GUS1 HEF3 HSP104 HTA1 KAP122 KGD1 KRE6 MAK16 MDH1 MET10 MET18 NAN1 NOP15 NOP2 NOP7 NSA1 OYE2 PFK1 PGM2 PRO2 PTC6 PYC1 RAD1 RNA1 RNR1 RNR2 RPF2 RPN1 RPN12 RPN5 RPN6 RPN8 RPN9 RPT1 RPT2 RRT6 SCS2 SEC26 SEC53 TEF4 TEM1 THI22 TIF1, TIF2 TIF6 TMA29 TPS1 TPS2 UTP10 UTP9 YDL086W YFR016C YGR066C YRB1 YTM1
    View Details Qiu et al. (2008) ALD4 ARG5,6 CIT1 IDH1 IDP1 KGD1 KGD2 LPD1 MDH1 PDA1 PDB1 SDH4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample zds1 from august 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run BOI2 Boi 2 gst control McCusker D, et al (2007)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data KGD1 Huh WK, et al. (2003)
    View Data KGD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..148] MSA 2.055989 View MSA. No confident structure predictions are available.
    2 View Details [149..275] MSA 1.297993 View MSA. No confident structure predictions are available.
    3 View Details [276..379]
    [397..559]    		 PSI-BLAST 70.154902 Transketolase (TK), Pyr module; Transketolase (TK), PP module; Transketolase (TK), C-domain
    4 View Details [380..396]
    [560..598]    		 PSI-BLAST 70.154902 Transketolase (TK), Pyr module; Transketolase (TK), PP module; Transketolase (TK), C-domain
    5 View Details [599..702] PSI-BLAST 70.154902 Transketolase (TK), Pyr module; Transketolase (TK), PP module; Transketolase (TK), C-domain
    6 View Details [703..881] PSI-BLAST 75.0 E1-beta subunit of pyruvate dehydrogenase, Pyr module; E1-beta subunit of pyruvate dehydrogenase, C-domain
    7 View Details [882..1014] PSI-BLAST 75.0 E1-beta subunit of pyruvate dehydrogenase, Pyr module; E1-beta subunit of pyruvate dehydrogenase, C-domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle