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Protein Overview: ARG5,6

General Information:
Name(s) found: ARG5,6 / YER069W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 863 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: arginine biosynthetic process [TASLink to PubMed article]
    ornithine biosynthetic process [TASLink to PubMed article]
    regulation of transcription [IMPLink to PubMed article]
    Molecular Function: N-acetyl-gamma-glutamyl-phosphate reductase activity [IDALink to PubMed article]
    acetylglutamate kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSASLLVST KRLNASKFQK FVSSLNKSTI AGFASVPLRA PPSVAFTRKK VGYSKRYVSS  60
   61 TNGFSATRST VIQLLNNIST KREVEQYLKY FTSVSQQQFA VIKVGGAIIS DNLHELASCL 120
  121 AFLYHVGLYP IVLHGTGPQV NGRLEAQGIE PDYIDGIRIT DEHTMAVVRK CFLEQNLKLV 180
  181 TALEQLGVRA RPITSGVFTA DYLDKDKYKL VGNIKSVTKE PIEASIKAGA LPILTSLAET 240
  241 ASGQMLNVNA DVAAGELARV FEPLKIVYLN EKGGIINGST GEKISMINLD EEYDDLMKQS 300
  301 WVKYGTKLKI REIKELLDYL PRSSSVAIIN VQDLQKELFT DSGAGTMIRR GYKLVKRSSI 360
  361 GEFPSADALR KALQRDAGIS SGKESVASYL RYLENSDFVS YADEPLEAVA IVKKDTNVPT 420
  421 LDKFVCSDAA WLNNVTDNVF NVLRRDFPAL QWVVSENDAN IAWHFDKSQG SYLKGGKVLF 480
  481 WYGIDDINTI SELVENFVKS CDTASTLNSS ASSGVFANKK SARSYSTRST PRPEGVNTNP 540
  541 GRVALIGARG YTGKNLVSLI NGHPYLEVAH VSSRELKGQK LQDYTKSEII YESLQIQDIR 600
  601 KLEEQNAVDF WVMALPNKVC EPFVETIQSV HGKSKIIDLS ADHRFVSESD WAYGLPELND 660
  661 RAKIANAAKI ANPGCYATGS QLTISPLTKY INGLPTVFGV SGYSGAGTKP SPKNDPKFLN 720
  721 NNLIPYALSD HIHEREISAR IGHNVAFMPH VGQWFQGISL TVSIPIKKGS LSIDEIRKLY 780
  781 RNFYEDEKLV HVIDDIPLVK DIEGTHGVVI GGFKLNDAED RVVVCATIDN LLKGAATQCL 840
  841 QNINLAMGYG EYAGIPENKI IGV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AME1 ARG5,6 CHL4 CTF19 CTF3 IML3 MCM16 MCM21 MCM22 NKP1 NKP2 OKP1 PRP18 SET4 YNR062C
    View Details Qiu et al. (2008) ARG5,6 IDP1 KGD1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ARG5,6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..96] deduced N/A No confident structure predictions are available.
    2 View Details [97..361] PSI-BLAST 86.512579 N-acetyl-l-glutamate kinase
    3 View Details [362..528] MSA 2.14199 View MSA. No confident structure predictions are available.
    4 View Details [529..673] PSI-BLAST 65.522879 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
    5 View Details [674..863] PSI-BLAST 65.522879 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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