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Protein Overview: CAR1

General Information:
Name(s) found: CAR1 / YPL111W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 333 amino acids

    Gene Ontology:
    Cellular Component: cytosol [TAS]
    Biological Process: arginine catabolic process to ornithine [TASLink to PubMed article]
    Molecular Function: zinc ion binding [IDALink to PubMed article]
    arginase activity [TASLink to PubMed article]
    manganese ion binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METGPHYNYY KNRELSIVLA PFSGGQGKLG VEKGPKYMLK HGLQTSIEDL GWSTELEPSM  60
   61 DEAQFVGKLK MEKDSTTGGS SVMIDGVKAK RADLVGEATK LVYNSVSKVV QANRFPLTLG 120
  121 GDHSIAIGTV SAVLDKYPDA GLLWIDAHAD INTIESTPSG NLHGCPVSFL MGLNKDVPHC 180
  181 PESLKWVPGN LSPKKIAYIG LRDVDAGEKK ILKDLGIAAF SMYHVDKYGI NAVIEMAMKA 240
  241 VHPETNGEGP IMCSYDVDGV DPLYIPATGT PVRGGLTLRE GLFLVERLAE SGNLIALDVV 300
  301 ECNPDLAIHD IHVSNTISAG CAIARCALGE TLL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CAR1 SVF1
    View Details Gavin AC, et al. (2002) CAR1 CDC60 GFA1
    View Details Ho Y, et al. (2002) CAR1 GSP1 GSP2 HYP2 IPP1 KGD1 MDH1 RNA1 YRB1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CAR1 CAR1 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CAR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..333] PSI-BLAST 612.519517 Arginase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • arginase activity
    		•  6.53441421234691 bayes_pls_golite062009
  • protein deacetylase activity
    		•  3.15425266272734 bayes_pls_golite062009
  • histone deacetylase activity
    		•  3.10913119405575 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.52770743634098 bayes_pls_golite062009
  • hydrolase activity
    		•  2.11707868768295 bayes_pls_golite062009
  • transcription factor binding
    		•  2.06538836131829 bayes_pls_golite062009
  • binding
    		•  1.948738669065 bayes_pls_golite062009
  • deacetylase activity
    		•  1.91016771390707 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  1.72243397396987 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.70671280294121 bayes_pls_golite062009
  • catalytic activity
    		•  1.68836803454021 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.59562744871718 bayes_pls_golite062009
  • DNA binding
    		•  1.55288325159263 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
    		•  1.01223037319069 bayes_pls_golite062009
  • transcription factor activity
    		•  0.882841288306625 bayes_pls_golite062009
  • protein binding
    		•  0.725535842743004 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.68008378742866 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.52929003055123 bayes_pls_golite062009
  • enzyme binding
    		•  0.39566582482721 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.38389503761392 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  0.0917282383800223 bayes_pls_golite062009
  • agmatinase activity
    		•  0.0741975192826536 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle