Protein Overview: CRM1

General Information:
Name(s) found:	CRM1 / YGR218W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|886910\|emb\|CAA61166.1\| CRM1 [Saccharomyces cerevisiae] [NCBI NR] gi\|6321657\|ref\|NP_011734.1\| Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; Crm1p [Saccharomyces cerevisiae] [NCBI NR] gi\|399300\|sp\|P30822.1\|XPO1_YEAST RecName: Full=Exportin-1; AltName: Full=Chromosome region maintenance protein 1; AltName: Full=Karyopherin-124 [NCBI NR] gi\|287601\|dbj\|BAA02371.1\| CRM1 protein [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S57681 CRM1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1323393\|emb\|CAA97246.1\| CRM1 [Saccharomyces cerevisiae] [NCBI NR] Exportin-1 OS=Saccharomyces cerevisiae GN=CRM1 PE=1 SV=1 [Swiss-Prot] CRM1 Nuclear export factor, exportin [mips] Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin [SGD] CRM1, Chr VII from 932534-935788 [yeast_orfs2] Chr VII from 932534-935788 [yeastorf3.fasta] Chr VII from 932541-935795 [yeastorf4.fasta] (P30822) Exportin 1 (Chromosome region maintenance protein 1) [4932.FASTACCERV.txt] CRM1 SGDID:S0003450, Chr VII from 932542-935796, Verified ORF [yeastflysequest.fasta] CRM1 SGDID:S0003450, Chr VII from 932544-935798, Verified ORF [10112005cervSGD.fasta] Crm1p [Saccharomyces cerevisiae]gi\|886910\|emb\|CAA61166.1\| ORF 1084 [Saccharomyces cerevisiae]gi\|1323393\|emb\|CAA97246.1\| CRM1 [Saccharomyces cerevisiae]gi\|399300\|sp\|P30822\|XPO1_YEAST Exportin 1 (Chromosome region maintenance protein 1)gi\|1362272\|pir\|\|S [nrdb_11152004_Chlamydomonas] CRM1 SGDID:S000003450, Chr VII from 932544-935798, Verified ORF, "Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] CRM1 SGDID:S000003450, Chr VII from 932544-935798, Verified ORF, "Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin" [yeast-200209-contam.fasta] CRM1 protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; Crm1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] CRM1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Exportin-1 (Chromosome region maintenance protein 1) [nr-271106-contam.fasta] [chemostatdb.fasta] Exportin-1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CRM1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] CRM1 SGDID:S000003450, Chr VII from 932541-935795, Genome Release 64-1-1, Verified ORF, "Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin" [yeast-030211-contam.fasta] CRM1 SGDID:S000003450, Chr VII from 932541-935795, Genome Release 64-2-1, Verified ORF, "Major karyopherin; involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin" [20141208_orf_trans.fasta] TR6386\|c0_g1_i1\|g.4564 ORF TR6386\|c0_g1_i1\|g.4564 TR6386\|c0_g1_i1\|m.4564 type:complete len:1085 (+) TR6386\|c0_g1_i1:304-3558(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YGR218W SGDID:S000003450, Chr VII from 932541-935795, Genome Release 64-1-1, Verified ORF, "Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_1237\|g.1310 ORF asmbl_1237\|g.1310 asmbl_1237\|m.1310 type:complete len:1085 (+) asmbl_1237:328-3582(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_1240\|g.880 ORF ID=asmbl_1240\|g.880 ID=asmbl_1240\|m.880 type:complete len:1085 (+) ID=asmbl_1240:328-3582(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	1084 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA]
Biological Process:	mRNA export from nucleus [IMP] ribosomal large subunit export from nucleus [IMP] protein export from nucleus [IMP]
Molecular Function:	protein transmembrane transporter activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGILDFSND LDIALLDQVV STFYQGSGVQ QKQAQEILTK FQDNPDAWQK ADQILQFSTN  60
   61 PQSKFIALSI LDKLITRKWK LLPNDHRIGI RNFVVGMIIS MCQDDEVFKT QKNLINKSDL 120
  121 TLVQILKQEW PQNWPEFIPE LIGSSSSSVN VCENNMIVLK LLSEEVFDFS AEQMTQAKAL 180
  181 HLKNSMSKEF EQIFKLCFQV LEQGSSSSLI VATLESLLRY LHWIPYRYIY ETNILELLST 240
  241 KFMTSPDTRA ITLKCLTEVS NLKIPQDNDL IKRQTVLFFQ NTLQQIATSV MPVTADLKAT 300
  301 YANANGNDQS FLQDLAMFLT TYLARNRALL ESDESLRELL LNAHQYLIQL SKIEERELFK 360
  361 TTLDYWHNLV ADLFYEVQRL PATEMSPLIQ LSVGSQAIST GSGALNPEYM KRFPLKKHIY 420
  421 EEICSQLRLV IIENMVRPEE VLVVENDEGE IVREFVKESD TIQLYKSERE VLVYLTHLNV 480
  481 IDTEEIMISK LARQIDGSEW SWHNINTLSW AIGSISGTMS EDTEKRFVVT VIKDLLDLTV 540
  541 KKRGKDNKAV VASDIMYVVG QYPRFLKAHW NFLRTVILKL FEFMHETHEG VQDMACDTFI 600
  601 KIVQKCKYHF VIQQPRESEP FIQTIIRDIQ KTTADLQPQQ VHTFYKACGI IISEERSVAE 660
  661 RNRLLSDLMQ LPNMAWDTIV EQSTANPTLL LDSETVKIIA NIIKTNVAVC TSMGADFYPQ 720
  721 LGHIYYNMLQ LYRAVSSMIS AQVAAEGLIA TKTPKVRGLR TIKKEILKLV ETYISKARNL 780
  781 DDVVKVLVEP LLNAVLEDYM NNVPDARDAE VLNCMTTVVE KVGHMIPQGV ILILQSVFEC 840
  841 TLDMINKDFT EYPEHRVEFY KLLKVINEKS FAAFLELPPA AFKLFVDAIC WAFKHNNRDV 900
  901 EVNGLQIALD LVKNIERMGN VPFANEFHKN YFFIFVSETF FVLTDSDHKS GFSKQALLLM 960
  961 KLISLVYDNK ISVPLYQEAE VPQGTSNQVY LSQYLANMLS NAFPHLTSEQ IASFLSALTK1020
 1021 QYKDLVVFKG TLRDFLVQIK EVGGDPTDYL FAEDKENALM EQNRLEREKA AKIGGLLKPS1080
 1081 ELDD

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CRM1 GEA2 MIR1 YHR020W
View Details	Gavin AC, et al. (2002)		BMH1 BMH2 CLU1 CRM1 ECM29 FKS1 GCN1 GEA2 GFA1 HRP1 HSP42 KAP104 KAP123 LCB1 LCB2 LYS12 MIR1 NAB2 NSL1 PDC1 PRP11 SAM1 SAM2 TAT1 YHR020W
View Details	Ho Y, et al. (2002)		AAC3 ADR1 ATG12 BBC1 BUD32 CAR2 CDC39 CDC53 CPR6 CRM1 DIA4 DUR1,2 ECM29 ECM33 FAA4 FET3 GAL3 GCN1 GRX3 GRX4 HEF3 HRT1 HYP2 IDP2 IMD2 IMD4 KAE1 KAP122 KGD1 MDN1 MET10 MET18 MKT1 MMS1 MYO2 NPA3 PFK1 PHO81 PMA2 RNH202 RPA190 RPN1 RPN5 RPN6 RPT1 SEC18 SEC23 SGO1 TMA29 TPS1 UBI4 URA7 VPS13 YAR009C YGP1 YHR033W YLR035C-A YRB2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..746]	MSA	33.191997	View MSA. No confident structure predictions are available.
2	View Details	[747..848]	deduced	N/A	Confident ab initio structure predictions are available.
3	View Details	[849..946]	ORFEUS	8.41	Hemoglobin, alpha-chain
4	View Details	[947..1084]	ORFEUS	8.41	Hemoglobin, alpha-chain

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
protein transporter activity	4.58709163830613	bayes_pls_golite062009
nuclear export signal receptor activity	3.48172991171337	bayes_pls_golite062009
binding	3.0667965351474	bayes_pls_golite062009
structural molecule activity	2.87774614675757	bayes_pls_golite062009
protein transmembrane transporter activity	2.74547353635661	bayes_pls_golite062009
cytoskeletal protein binding	2.61566088685247	bayes_pls_golite062009
transporter activity	2.48700774379895	bayes_pls_golite062009
nucleic acid binding	2.34284977509828	bayes_pls_golite062009
substrate-specific transporter activity	2.26725422172281	bayes_pls_golite062009
signal sequence binding	2.11631489628537	bayes_pls_golite062009
RNA binding	1.98024495780436	bayes_pls_golite062009
nuclear localization sequence binding	1.91487015967262	bayes_pls_golite062009
actin binding	1.76244772281676	bayes_pls_golite062009
transcription regulator activity	1.76231475025891	bayes_pls_golite062009
protein binding	1.73688475473996	bayes_pls_golite062009
mRNA binding	1.71342954033223	bayes_pls_golite062009
DNA binding	1.62032607987786	bayes_pls_golite062009
transmembrane transporter activity	1.28481004323799	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.09652988954158	bayes_pls_golite062009
transcription factor activity	0.923253759652909	bayes_pls_golite062009
translation initiation factor activity	0.83079633551839	bayes_pls_golite062009
translation regulator activity	0.82193201542158	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.803700928110921	bayes_pls_golite062009
molecular transducer activity	0.662662274021266	bayes_pls_golite062009
signal transducer activity	0.662662274021266	bayes_pls_golite062009
hydrolase activity	0.42501390959416	bayes_pls_golite062009
importin-alpha export receptor activity	0.259676026705859	bayes_pls_golite062009
active transmembrane transporter activity	0.252495966234234	bayes_pls_golite062009
ion transmembrane transporter activity	0.248585912061178	bayes_pls_golite062009
primary active transmembrane transporter activity	0.226380819487924	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.217517113570989	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.178770060806735	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.175241020572885	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.174922130116569	bayes_pls_golite062009
protein phosphatase binding	0.11022839198649	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.100181463251306	bayes_pls_golite062009
pyrophosphatase activity	0.0635404099346928	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0548082069333885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.052195223119721	bayes_pls_golite062009
cation transmembrane transporter activity	0.0405268469927988	bayes_pls_golite062009
transcription activator activity	0.0232727461674547	bayes_pls_golite062009

Term	Confidence	Notes
protein transporter activity	4.58709163830613	bayes_pls_golite062009
nuclear export signal receptor activity	3.48172991171337	bayes_pls_golite062009
binding	3.0667965351474	bayes_pls_golite062009
structural molecule activity	2.87774614675757	bayes_pls_golite062009
protein transmembrane transporter activity	2.74547353635661	bayes_pls_golite062009
cytoskeletal protein binding	2.61566088685247	bayes_pls_golite062009
transporter activity	2.48700774379895	bayes_pls_golite062009
nucleic acid binding	2.34284977509828	bayes_pls_golite062009
substrate-specific transporter activity	2.26725422172281	bayes_pls_golite062009
signal sequence binding	2.11631489628537	bayes_pls_golite062009
RNA binding	1.98024495780436	bayes_pls_golite062009
nuclear localization sequence binding	1.91487015967262	bayes_pls_golite062009
actin binding	1.76244772281676	bayes_pls_golite062009
transcription regulator activity	1.76231475025891	bayes_pls_golite062009
protein binding	1.73688475473996	bayes_pls_golite062009
mRNA binding	1.71342954033223	bayes_pls_golite062009
DNA binding	1.62032607987786	bayes_pls_golite062009
transmembrane transporter activity	1.28481004323799	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.09652988954158	bayes_pls_golite062009
transcription factor activity	0.923253759652909	bayes_pls_golite062009
translation initiation factor activity	0.83079633551839	bayes_pls_golite062009
translation regulator activity	0.82193201542158	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.803700928110921	bayes_pls_golite062009
molecular transducer activity	0.662662274021266	bayes_pls_golite062009
signal transducer activity	0.662662274021266	bayes_pls_golite062009
hydrolase activity	0.42501390959416	bayes_pls_golite062009
importin-alpha export receptor activity	0.259676026705859	bayes_pls_golite062009
active transmembrane transporter activity	0.252495966234234	bayes_pls_golite062009
ion transmembrane transporter activity	0.248585912061178	bayes_pls_golite062009
primary active transmembrane transporter activity	0.226380819487924	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.217517113570989	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.178770060806735	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.175241020572885	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.174922130116569	bayes_pls_golite062009
protein phosphatase binding	0.11022839198649	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.100181463251306	bayes_pls_golite062009
pyrophosphatase activity	0.0635404099346928	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0548082069333885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.052195223119721	bayes_pls_golite062009
cation transmembrane transporter activity	0.0405268469927988	bayes_pls_golite062009
transcription activator activity	0.0232727461674547	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

	PROTEIN(S)	PUBLICATION
View Data	CRM1	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: CRM1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: