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Protein Overview: KAP114

General Information:
Name(s) found: KAP114 / YGL241W [SGD]
Description(s) found:
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  • gi|793871|emb|CAA89014.1| HRC1004 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6321196|ref|NP_011273.1| Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; Kap114p [Saccharomyces [NCBI NR]
  • gi|1723977|sp|P53067.1|IMB5_YEAST RecName: Full=Importin subunit beta-5; AltName: Full=Karyopherin subunit beta-5; AltName: Full=Karyopherin-114; AltName: Full=114 kDa karyopherin [NCBI NR]
  • gi|1589351|prf||2210407F HRC1004 gene [NCBI NR]
  • gi|1322907|emb|CAA96960.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S53939 probable membrane protein YGL241w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Importin subunit beta-5 OS=Saccharomyces cerevisiae GN=KAP114 PE=1 SV=1 [Swiss-Prot]
  • KAP114 Member of the karyopherin-beta family, nuclear import [mips]
  • Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear [SGD]
  • KAP114, Chr VII from 45445-48459 [yeast_orfs2]
  • Chr VII from 45445-48459 [yeastorf3.fasta]
  • (P53067) Importin beta-5 subunit (Karyopherin beta-5 subunit) (114 kDa karyopherin) [4932.FASTACCERV.txt]
  • KAP114 SGDID:S0003210, Chr VII from 45445-48459, Verified ORF [yeastflysequest.fasta]
  • Kap114p [Saccharomyces cerevisiae]gi|1322907|emb|CAA96960.1| unnamed protein product [Saccharomyces cerevisiae]gi|793871|emb|CAA89014.1| HRC1004 [Saccharomyces cerevisiae]gi|1077169|pir||S53939 probable membrane protein YGL241w - yeast (Saccharomyces c [nrdb_11152004_Chlamydomonas]
  • KAP114 SGDID:S000003210, Chr VII from 45445-48459, Verified ORF, "Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is prim [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Importin beta-5 subunit (Karyopherin beta-5 subunit) (114 kDa karyopherin) [nr-271106-contam.fasta]
  • HRC1004 gene [nr-271106-contam.fasta]
  • HRC1004 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; Kap114p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • KAP114 SGDID:S000003210, Chr VII from 45445-48459, Verified ORF, "Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Importin subunit beta-5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KAP114 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • KAP114 SGDID:S000003210, Chr VII from 45445-48459, Genome Release 64-1-1, Verified ORF, "Karyopherin, responsible for nuclear import of Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear" [yeast-030211-contam.fasta]
  • KAP114 SGDID:S000003210, Chr VII from 45445-48459, Genome Release 64-2-1, Verified ORF, "Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress" [20141208_orf_trans.fasta]
  • YGL241W SGDID:S000003210, Chr VII from 45445-48459, Genome Release 64-1-1, Verified ORF, "Karyopherin, responsible for nuclear import of Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1004 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: protein import into nucleus [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: protein transmembrane transporter activity [IPILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDINELIIGA QSADKHTREV AETQLLQWCD SDASQVFKAL ANVALQHEAS LESRQFALLS  60
   61 LRKLITMYWS PGFESYRSTS NVEIDVKDFI REVLLKLCLN DNENTKIKNG ASYCIVQISA 120
  121 VDFPDQWPQL LTVIYDAISH QHSLNAMSLL NEIYDDVVSE EMFFEGGIGL ATMEIVFKVL 180
  181 NTETSTLIAK IAALKLLKAC LLQMSSHNEY DEASRKSFVS QCLATSLQIL GQLLTLNFGN 240
  241 VDVISQLKFK SIIYENLVFI KNDFSRKHFS SELQKQFKIM AIQDLENVTH INANVETTES 300
  301 EPLLETVHDC SIYIVEFLTS VCTLQFSVEE MNKIITSLTI LCQLSSETRE IWTSDFNTFV 360
  361 SKETGLAASY NVRDQANEFF TSLPNPQLSL IFKVVSNDIE HSTCNYSTLE SLLYLLQCIL 420
  421 LNDDEITGEN IDQSLQILIK TLENILVSQE IPELILARAI LTIPRVLDKF IDALPDIKPL 480
  481 TSAFLAKSLN LALKSDKELI KSATLIAFTY YCYFAELDSV LGPEVCSETQ EKVIRIINQV 540
  541 SSDAEEDTNG ALMEVLSQVI SYNPKEPHSR KEILQAEFHL VFTISSEDPA NVQVVVQSQE 600
  601 CLEKLLDNIN MDNYKNYIEL CLPSFINVLD SNNANNYRYS PLLSLVLEFI TVFLKKKPND 660
  661 GFLPDEINQY LFEPLAKVLA FSTEDETLQL ATEAFSYLIF NTDTRAMEPR LMDIMKVLER 720
  721 LLSLEVSDSA AMNVGPLVVA IFTRFSKEIQ PLIGRILEAV VVRLIKTQNI STEQNLLSVL 780
  781 CFLTCNDPKQ TVDFLSSFQI DNTDALTLVM RKWIEAFEVI RGEKRIKENI VALSNLFFLN 840
  841 DKRLQKVVVN GNLIPYEGDL IITRSMAKKM PDRYVQVPLY TKIIKLFVSE LSFQSKQPNP 900
  901 EQLITSDIKQ EVVNANKDDD NDDWEDVDDV LDYDKLKEYI DDDVDEEADD DSDDITGLMD 960
  961 VKESVVQLLV RFFKEVASKD VSGFHCIYET LSDSERKVLS EALL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) HTA2 HTB1 HTZ1 KAP114 NAP1 POB3 PSY2 SPT16 VPS1
    View Details Krogan NJ, et al. (2006) GIN4 HFD1 HTZ1 KAP114 KCC4 NAP1 PRO3 REI1 RIM11 RPS6A, RPS6B UBC8 VIP1 WTM1 YKR011C
    View Details Gavin AC, et al. (2002) ADA2 ADH1 CLU1 DPB2 DPB4 FUN19 GCN1 GCN5 GIN4 HEM13 HTZ1 ISW1 ISW2 KAP114 KAP123 KCC4 LYS12 MED4 MES1 MNN4 MOT1 MYO1 NAP1 NBA1 NGG1 NIS1 NOP1 NPL6 PDC1 PFK2 POL2 PSK1 PTC1 PUF6 RET1 RPA135 RPB2 RPC82 RPN9 RPO21 RPO31 RPT5 RVB2 SGF29 SGF73 SIN3 SIN4 SPT15 SPT20 SPT7 SPT8 SSC1 STH1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TEF4 TOP1 VAS1 VPS1 YEF3 YRA1
    View Details Ho Y, et al. (2002) AIP1 COF1 CYR1 GCN1 HHF1, HHF2 HIR2 HTA1 HTB1 KAP114 KRI1 NAP1 NOP4 NOP7 PHO81 RET1 REX2 RPC82 RPO31 SPT16 SRV2 TOS3 UTP13

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBC7 KAP114 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data KAP114 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..704] MSA 13.126979 View MSA. No confident structure predictions are available.
    2 View Details [705..915] MSA 2.087982 View MSA. No confident structure predictions are available.
    3 View Details [916..1004] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle