Protein Overview: EDC3

General Information:
Name(s) found:	EDC3 / YEL015W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|731402\|sp\|P39998.1\|EDC3_YEAST RecName: Full=Enhancer of mRNA-decapping protein 3 [NCBI NR] gi\|6320822\|ref\|NP_010901.1\| Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; Edc3p [Saccharomyces cer [NCBI NR] gi\|602382\|gb\|AAB64492.1\| Yel015wp [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S50444 hypothetical protein YEL015w - yeast (Saccharomyces cerevisiae) [NCBI NR] (P39998) Hypothetical 61.3 kDa protein in PMP2-VAC8 intergenic region [Swiss-Prot] Enhancer of mRNA-decapping protein 3 OS=Saccharomyces cerevisiae GN=EDC3 PE=1 SV=1 [Swiss-Prot] EDC3 Enhancer of mRNA DeCapping [mips] Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies [SGD] YEL015W, Chr V from 126629-128284 [yeast_orfs2] Chr V from 126629-128284 [yeastorf3.fasta] EDC3 SGDID:S0000741, Chr V from 126629-128284, Verified ORF [yeastflysequest.fasta] Edc3p [Saccharomyces cerevisiae]gi\|731402\|sp\|P39998\|YEB5_YEAST Hypothetical 61.3 kDa protein in PMP2-VAC8 intergenic regiongi\|1077596\|pir\|\|S50444 hypothetical protein YEL015w - yeast (Saccharomyces cerevisiae)gi\|602382\|gb\|AAB64492.1\| Yel015wp [Saccharo [nrdb_11152004_Chlamydomonas] EDC3 SGDID:S000000741, Chr V from 126629-128284, Verified ORF, "Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA process [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Enhancer of mRNA decapping protein 3 [nr-271106-contam.fasta] Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; Edc3p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Yel015wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] EDC3 SGDID:S000000741, Chr V from 126629-128284, Verified ORF, "Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Enhancer of mRNA-decapping protein 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EDC3 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] EDC3 SGDID:S000000741, Chr V from 126629-128284, Genome Release 64-1-1, Verified ORF, "Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies" [yeast-030211-contam.fasta] EDC3 SGDID:S000000741, Chr V from 126629-128284, Genome Release 64-2-1, Verified ORF, "Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; mediates decay of the RPS28B mRNA via binding to both Rps28Bp (or Rps28Ap) and the RPS28B mRNA; mediates decay of the YRA1 mRNA by a different, translation-independent mechanism; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress" [20141208_orf_trans.fasta] YEL015W SGDID:S000000741, Chr V from 126629-128284, Genome Release 64-1-1, Verified ORF, "Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	551 amino acids
Gene Ontology:
Cellular Component:	cytoplasmic mRNA processing body [IDA]
Biological Process:	deadenylation-independent decapping of nuclear-transcribed mRNA [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQFVGFGVQ VELKDGKLIQ GKIAKATSKG LTLNDVQFGD GGKSQAFKVR ASRLKDLKVL  60
   61 TVASQSGKRK QQRQQQQQND YNQNRGEHID WQDDDVSKIK QQEDFDFQRN LGMFNKKDVF 120
  121 AQLKQNDDIL PENRLQGHNR KQTQLQQNNY QNDELVIPDA KKDSWNKISS RNEQSTHQSQ 180
  181 PQQDAQDDLV LEDDEHEYDV DDIDDPKYLP ITQSLNITHL IHSATNSPSI NDKTKGTVIN 240
  241 DKDQVLAKLG QMIISQSRSN STSLPAANKQ TTIRSKNTKQ NIPMATPVQL LEMESITSEF 300
  301 FSINSAGLLE NFAVNASFFL KQKLGGRARL RLQNSNPEPL VVILASDSNR SGAKALALGR 360
  361 HLCQTGHIRV ITLFTCSQNE LQDSMVKKQT DIYKKCGGKI VNSVSSLESA METLNSPVEI 420
  421 VIDAMQGYDC TLSDLAGTSE VIESRIKSMI SWCNKQRGST KVWSLDIPNG FDAGSGMPDI 480
  481 FFSDRIEATG IICSGWPLIA INNLIANLPS LEDAVLIDIG IPQGAYSQRT SLRKFQNCDL 540
  541 FVTDGSLLLD L

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		DCP1 DCP2 DHH1 EDC3 PBY1
View Details	Krogan NJ, et al. (2006)		DCP1 DCP2 EDC2 EDC3 PBY1
View Details	Gavin AC, et al. (2006)		DCP1 DCP2 EDC3
View Details	Gavin AC, et al. (2002)		DCP1 DCP2 EDC3 RPM2
View Details	Ho Y, et al. (2002)		ABP1 ACO1 AIM41 ATP4 BUD14 CAR2 CDC25 CKA2 COR1 CRZ1 CYS4 DCP1 DCP2 DNM1 EDC3 EDE1 EGD2 ENP1 FPR3 GAS1 GCN3 GLC7 GPH1 HHF1, HHF2 HRR25 HSP104 HXT7 HYP2 IPP1 LOC1 LSP1 LTV1 MDH1 MDS3 MGE1 NSA1 NUG1 OYE2 PEX19 PIL1 PIN4 PTC4 PUF3 RIO2 RPC19 RPM2 SAP185 SAP190 SAS10 SEC2 SEC23 SES1 SFB3 SGM1 SIT4 TGL1 TMA19 TSR1 VMA4 YBR225W YER138C
View Details	Qiu et al. (2008)		DCP1 DCP2 EDC3 LSM1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	TOR1	No Comments	Reinke A, et al. (2004)
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	ZDS1	Sample 2- cpn2 from june 2005	McCusker D, et al (2007)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	MPC54	EDC3	2	Unpublished Fields Lab Data
View Screen	LSM8	EDC3	2	Uetz P, et al. (2000)
View Screen	LOS1	EDC3	2	Unpublished Fields Lab Data
View Screen	TEM1	EDC3	2	Uetz P, et al. (2000)
View Screen	PSE1	EDC3	1	Unpublished Fields Lab Data
View Screen	NAF1	EDC3	1	Hazbun TR, et al. (2003)
View Screen	APC5	EDC3	1	Unpublished Fields Lab Data
View Screen	LSM2	EDC3	1	Unpublished Fields Lab Data
View Screen	GIR2	EDC3	1	Unpublished Fields Lab Data
View Screen	RAD9	EDC3	1	Unpublished Fields Lab Data
View Screen	LSM4	EDC3	1	Unpublished Fields Lab Data
View Screen	MET30	EDC3	1	Uetz P, et al. (2000)
View Screen	YJR141W	EDC3	1	Unpublished Fields Lab Data
View Screen	MDM30	EDC3	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	EDC3	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..265]	deduced	N/A	No confident structure predictions are available.
2	View Details	[266..551]	PSI-BLAST	40.39794	Hypothetical protein YNL200c (YNU0 YEAST)
3	View Details	[276..551]	PSI-BLAST	43.69897	Hypothetical protein YNL200c (YNU0 YEAST)

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.96

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2