YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: SAC6

General Information:
Name(s) found: SAC6 / YDR129C [SGD]
Description(s) found:
SHOW ONLY BEST
  • gi|665661|emb|CAA88210.1| Sac6p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6320334|ref|NP_010414.1| Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; Sac6p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|462098|sp|P32599.1|FIMB_YEAST RecName: Full=Fimbrin; AltName: Full=ABP67 [NCBI NR]
  • gi|4420|emb|CAA45346.1| fimbrin [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S29320 fimbrin - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|228301|prf||1802390A fimbrin [NCBI NR]
  • Fimbrin OS=Saccharomyces cerevisiae GN=SAC6 PE=1 SV=1 [Swiss-Prot]
  • SAC6 Actin filament bundling protein, fimbrin [mips]
  • Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton [SGD]
  • SAC6, Chr IV from 713333-713353,713465-715372, reverse complement [yeast_orfs2]
  • Chr IV from 713333-713353,713465-715372, reverse complement [yeastorf3.fasta]
  • Chr IV from 715372-715352,715240-713333, reverse complement [yeastorf5.fasta]
  • (P32599) Fimbrin (ABP67) [4932.FASTACCERV.txt]
  • SAC6 SGDID:S0002536, Chr IV from 715373-715353,715241-713334, reverse complement, Verified ORF [yeastflysequest.fasta]
  • SAC6 SGDID:S0002536, Chr IV from 715374-715354,715242-713335, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton [Saccharomyces cerevisiae]gi|665661|emb|CAA88210.1| Sac6p [Saccharomyces cerevisiae]gi|4420|emb|CAA45346.1| fimbri [nrdb_11152004_Chlamydomonas]
  • SAC6 SGDID:S000002536, Chr IV from 715374-715354,715242-713335, reverse complement, Verified ORF, "Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • SAC6 SGDID:S000002536, Chr IV from 715376-715356,715244-713337, reverse complement, Verified ORF, "Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton" [yeast-contam.fasta]
  • SAC6 SGDID:S000002536, Chr IV from 715377-715357,715245-713338, reverse complement, Verified ORF, "Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • fimbrin [nr-271106-contam.fasta]
  • Sac6p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Fimbrin (ABP67) [nr-271106-contam.fasta]
  • Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; Sac6p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • fimbrin [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Fimbrin OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SAC6 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • SAC6 SGDID:S000002536, Chr IV from 715247-713340,715379-715359, Genome Release 64-1-1, reverse complement, Verified ORF, "Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton" [yeast-030211-contam.fasta]
  • SAC6 SGDID:S000002536, Chr IV from 715247-713340,715379-715359, Genome Release 64-2-1, reverse complement, Verified ORF, "Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress" [20141208_orf_trans.fasta]
  • YDR129C SGDID:S000002536, Chr IV from 715247-713340,715379-715359, Genome Release 64-1-1, reverse complement, Verified ORF, "Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 642 amino acids

    Gene Ontology:
    Cellular Component: actin cortical patch [IDALink to PubMed article]
    Biological Process: bipolar cellular bud site selection [IMPLink to PubMed article]
    response to osmotic stress [IMPLink to PubMed article]
    actin filament organization [IMPLink to PubMed article][IPILink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    Molecular Function: actin filament binding [IDALink to PubMed article]
    protein binding, bridging [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNIVKLQRKF PILTQEDLFS TIEKFRAIDL DDKGWVEKQQ ALEAVSKDGD ATYDEARETL  60
   61 KHVGVDASGR VELDDYVGLV AKLRESKTGA APQTTFNVAP NSTPIVSTAA TGLQHKGKGT 120
  121 QAKIIVAGSQ TGTTHTINEE ERREFTKHIN SVLAGDQDIG DLLPFPTDTF QLFDECRDGL 180
  181 VLSKLINDSV PDTIDTRVLN WPKKGKELNN FQASENANIV INSAKAIGCV VVNVHSEDII 240
  241 EGREHLILGL IWQIIRRGLL SKIDIKLHPE LYRLLEDDET LEQFLRLPPE QILLRWFNYH 300
  301 LKQANWNRRV TNFSKDVSDG ENYTILLNQL DPALCSKAPL QTTDLMERAE QVLQNAEKLD 360
  361 CRKYLTPSSL VAGNPKLNLA FVAHLFNTHP GLEPIQEEEK PEIEEFDAEG EREARVFTLW 420
  421 LNSLDVDPPV ISLFDDLKDG LILLQAYEKV MPGAVDFKHV NKRPASGAEI SRFKALENTN 480
  481 YAVDLGRAKG FSLVGIEGSD IVDGNKLLTL GLVWQLMRRN ISITMKTLSS SGRDMSDSQI 540
  541 LKWAQDQVTK GGKNSTIRSF KDQALSNAHF LLDVLNGIAP GYVDYDLVTP GNTEEERYAN 600
  601 ARLAISIARK LGALIWLVPE DINEVRARLI ITFIASLMTL NK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ABP1 CMD1 CRN1 ECM10 EFT2, EFT1 LSP1 MLC1 RVS161 SAC6 TWF1
    View Details (MIPS) Mewes HW, et al. (2004) ABP1 AIP1 ARC40 ARP2 BEM1 BUD6 CAP1 CAP2 COF1 CRN1 DLD2 GLK1 LAS17 OYE2 PAN1 PFY1 RVS167 SAC6 SLA1 SLA2 SRV2 TPM1 TPM2 TWF1 VRP1
    View Details Krogan NJ, et al. (2006) ARC15 ASR1 CAJ1 CDC7 CRN1 INP52 IRC22 MSK1 PNO1 PST2 RAD34 SAC6 SAR1 SLM1 TCP1 TED1 YPP1
    View Details Gavin AC, et al. (2006) ACT1 SAC6
    View Details Ho Y, et al. (2002) ACS2 ADE3 ADE6 ADO1 ALA1 APE2 ARA1 BAT1 CDC10 CLU1 CYS3 DED81 DPS1 ERG10 ERG20 FAA4 FPR1 GCY1 GPH1 GRS1 HOM2 HYP2 ILS1 IMD3 KRS1 LSP1 MDH1 MDH3 OLA1 PAB1 PFK2 PGM2 PMI40 PRP6 PSR2 SAC6 SCP160 SOD1 SSZ1 THR4 TRP5 TRR1 UBA1 YDL124W
    View Details Qiu et al. (2008) ABP1 ACT1 AIP1 ARC40 ARP2 BBC1 BSP1 BUD6 CAP1 CAP2 COF1 CRN1 EDE1 END3 ENT1 HOF1 LAS17 MYO2 MYO5 PAN1 PFY1 RVS161 RVS167 SAC6 SCP1 SLA1 SLA2 SRV2 TPM1 TPM2 TWF1 VRP1 YSC84

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VRP1 and SAC6 Huh WK, et al. (2003)
    View Data MYO5 and SAC6 Huh WK, et al. (2003)
    View Data SLA1 and SAC6 Huh WK, et al. (2003)
    View Data ARC15 and SAC6 Huh WK, et al. (2003)
    View Data TWF1 and SAC6 Huh WK, et al. (2003)
    View Data RVS161 and SAC6 Huh WK, et al. (2003)
    View Data AIM21 and SAC6 Huh WK, et al. (2003)
    View Data AIP1 and SAC6 Huh WK, et al. (2003)
    View Data SCP1 and SAC6 Huh WK, et al. (2003)
    View Data ENT2 and SAC6 Huh WK, et al. (2003)
    View Data BZZ1 and SAC6 Huh WK, et al. (2003)
    View Data ENT1 and SAC6 Huh WK, et al. (2003)
    View Data ARC19 and SAC6 Huh WK, et al. (2003)
    View Data BBC1 and SAC6 Huh WK, et al. (2003)
    View Data SAC6 and SAC6 Huh WK, et al. (2003)
    View Data SRV2 and SAC6 Huh WK, et al. (2003)
    View Data ARK1 and SAC6 Huh WK, et al. (2003)
    View Data SAC6 Huh WK, et al. (2003)
    View Data MYO3 and SAC6 Huh WK, et al. (2003)
    View Data GTS1 and SAC6 Huh WK, et al. (2003)
    View Data ARC35 and SAC6 Huh WK, et al. (2003)
    View Data INP52 and SAC6 Huh WK, et al. (2003)
    View Data ARC40 and SAC6 Huh WK, et al. (2003)
    View Data PRK1 and SAC6 Huh WK, et al. (2003)
    View Data LSB3 and SAC6 Huh WK, et al. (2003)
    View Data CAP1 and SAC6 Huh WK, et al. (2003)
    View Data BSP1 and SAC6 Huh WK, et al. (2003)
    View Data ARC18 and SAC6 Huh WK, et al. (2003)
    View Data ABP1 and SAC6 Huh WK, et al. (2003)
    View Data LAS17 and SAC6 Huh WK, et al. (2003)
    View Data CRN1 and SAC6 Huh WK, et al. (2003)
    View Data CAP2 and SAC6 Huh WK, et al. (2003)
    View Data RVS167 and SAC6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..121] PSI-BLAST 45.045757 Calmodulin
    2 View Details [122..261] PSI-BLAST 693.450636 N-terminal actin-crosslinking domain from fimbrin
    3 View Details [262..391] PSI-BLAST 693.450636 N-terminal actin-crosslinking domain from fimbrin
    4 View Details [392..528] PSI-BLAST 6.045757 Genetically engineered molecular motor
    5 View Details [529..642] ORFEUS 14.99 beta-spectrin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  3.96919556235483 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.49668552859347 bayes_pls_golite062009
  • structural constituent of muscle
    		•  3.12414907235012 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.9702957313812 bayes_pls_golite062009
  • binding
    		•  2.74623080162785 bayes_pls_golite062009
  • motor activity
    		•  2.57627414053278 bayes_pls_golite062009
  • actin filament binding
    		•  2.35534489389161 bayes_pls_golite062009
  • myosin binding
    		•  2.34125070430971 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  2.06646671333275 bayes_pls_golite062009
  • calcium ion binding
    		•  1.40919295397643 bayes_pls_golite062009
  • ion binding
    		•  1.36376383271837 bayes_pls_golite062009
  • metal ion binding
    		•  1.34827363853601 bayes_pls_golite062009
  • cation binding
    		•  1.34827363853601 bayes_pls_golite062009
  • protein binding
    		•  1.16246005294206 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • actin monomer binding
    		•  0.9954841049256 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.841197898920128 bayes_pls_golite062009
  • structural molecule activity
    		•  0.800850121197479 bayes_pls_golite062009
  • S100 beta binding
    		•  0.761814775111873 bayes_pls_golite062009
  • tubulin binding
    		•  0.710693016758742 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.693724160233023 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.61866037435065 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.582813108431922 bayes_pls_golite062009
  • DNA binding
    		•  0.50926539916695 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.45412801027969 bayes_pls_golite062009
  • myosin II binding
    		•  0.311147527050891 bayes_pls_golite062009
  • microtubule binding
    		•  0.278596514315141 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.267701820661496 bayes_pls_golite062009
  • signal transducer activity
    		•  0.267701820661496 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.193201281459889 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.168674124705245 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.116648335890738 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0305250212662123 bayes_pls_golite062009
    2
    Term Confidence Notes
  • actin binding
    		•  7.50245214720686 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  6.48140000563569 bayes_pls_golite062009
  • actin filament binding
    		•  5.47084878097979 bayes_pls_golite062009
  • tubulin binding
    		•  4.22039137964246 bayes_pls_golite062009
  • microtubule binding
    		•  4.15537672860167 bayes_pls_golite062009
  • binding
    		•  2.8655705697659 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  2.57886434162184 bayes_pls_golite062009
  • protein binding
    		•  2.36488136094907 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  2.0465241878708 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.32485442580942 bayes_pls_golite062009
  • structural molecule activity
    		•  1.00964022808548 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle